Kyle Happel, MD, FCCPLSUHSC School of Medicine

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About Us

	Kyle Happel, MD, FCCP Associate Professor of Medicine 1901 Perdido Street Suite 3205 New Orleans, LA 70112 Phone: (504) 568-4634 Fax: (504) 568-4295 khappe@lsuhsc.edu
Degrees	BS Biochemistry - 1993 Louisiana State University, Baton Rouge MD - 1997 LSU School of Medicine - New Orleans
Bio	Dr. Happel is an assistant Professor of Medicine and is the newest faculty addition to the University's Alcohol Research Center, having joined the group in 2004. He is currently supported by an NIH career development award, and his research focus is pulmonary host defense mechanisms and the effects of ethanol consumption. In particular, the mechanisms by which ethanol impairs the adaptive response to infection are his specific interests. The long range goals of his research are to understand the specific mechanisms by which alcohol abuse impairs the lung's defenses to infection and to develop novel treatments which can overcome these acquired defects. Internship and Residency: Internal Medicine Vanderbilt University Medical Center Nashville, Tennessee Fellowship: Pulmonary and Critical Care Medicine Louisiana State University Health Science Center New Orleans, LA Licensure and Certification: Louisiana State Medical License (2000) Board Certified, Internal Medicine (2000) Board Certified, Pulmonary Disease (2002) Board Certified, Critical Care Medicine (2003)
Clinical Interests	Pneumonia (community and hospital acquired) Asthma
Research Interests	Bacterial host defenses in the lungs, particularly the adaptive immune response
Committees & Administrative Responsibilities	Chairman, Pharmaceutical and Therapeutics Committee Medical Center of LA – New Orleans (University Hospital)
Selected Publications	Zhang P, Welsh DA, Siggins RW 2nd, Bagby GJ, Raasch CE, Happel KI, Nelson S. Acute alcohol intoxication inhibits the lineage- c-kit+ Sca-1+ cell response to Escherichia coli bacteremia. J Immunol 2009 Feb; 182(3): 1568-76. Walker JE Jr, Odden AR, Jeyaseelan S, Zhang P, Bagby GJ, Nelson S, Happel KI. Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication. Alcohol Clin Exp Res 2009 Feb; 33(2): 357-65. Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd J, Zhang P, Nelson S. The Systemic and Pulmonary Lipopolysaccharide Binding Protein Response to Intratracheal Lipopolysaccharide. Shock 2009 Feb; 31(2): 212-7. Zhang P, Bagby GJ, Happel KI, Raasch CE, and Neslon S. Alcohol Abuse, Immunosuppression, and Pulmonary Infection. Current Drug Abuse Reviews. 2008; 1: 56-67. Happel KI, Rudner XL, Quinton LQ, Movassaghi JL, et al. Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. Alcohol 2007 Oct; 41: 325-333. Rudner XL, Happel KI, Young EA, Shellito JE. The IL-23/IL-17 Cytokine Axis in Murine Pneumocystis Infection. Infect Immun. 2007 Apr 2. Happel KI, Odden AR, Zhang P, Shellito JE, Bagby GJ, Nelson S, Acute alcohol intoxication suppresses the IL-23 response to Klebsiella pneumoniae infection, Alcohol Clin Exp Res Jul;30(7), 2006. Kelly MN, Kolls JK, Happel KI, Schwartzman JD, Schwarzenberger P, Combe C, Moretto M, Khan IA, Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection, Infection and Immunity Jan;73(1):617-21, 2005. Happel KI, Nelson S, Alcohol, immunosuppression, and the lung., Proceedings of the American Thoracic Society 2(5):428-32, 2005. Happel KI, Lockhart EA, Mason CM, Porretta E, Keoshkerian E, Odden AR, Nelson S, Ramsay AJ, Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs, Infection and Immunity Sep;73(9):5782-8, 2005. Thiele GM, Mandrekar P, Zakhari S, Hoek J, Cook RT, Ray NB, Happel KI, Kolls JK, Kovacs EJ, Szab G, RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ damage, Alcohol Clin Exp Res Sep;29(9):1735-43, 2005. Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK, Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae, J Exp Med Sep 19;202(6):761-9, 2005.