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| Degrees |
BA - 1984 MD - 1989 |
| Bio |
Dr. Welsh's research activities range from laboratory investigations to clinical studies. His laboratory is focused on the biology of adult bone marrow derived stem cells as it relates to lung disease. Ongoing projects seek to determine the role of deficient stem cell trafficking to the lung in the pathogenesis of emphysema and to define the mechanisms involved in stem cell mobilization & engraftment in the lung using pre-clinical models. His translational research interests include the role of CD44 in bone marrow stem cell function in human emphysema. Additionally, Dr. Welsh serves as the Associate Director of the Louisiana Healthy Aging Study. He has developed a panel of indices of fitness that are used in this study of the genetic & metabolic determinants of successful aging. Dr. Welsh also supervises the research arm of the MCLNO HIV-Associated Pneumonia Management Program which analyzes factors influencing patient's clinical outcomes as well as serving as a resource for a number of ancillary studies by providing samples from a specimen bank linked to clinical data. |
| Research Interests |
Mesenchymal Stem Cells (MSCs) Emphysema Aging Human Immunodeficiency Virus (HIV) |
| Selected Publications |
Huang L, DA Welsh, RF Miller, CB Beard, GG Lawrence, M Fox, A Swartzman, M Bensley, D Carbonnet, JL Davis, A Chi, BJ Yoo, JL Jones, Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations and Human Immunodeficiency Virus-Associated Pneumocystis Pneumonia, Submitted to J Eukaryot Microbiol 53:S114-S116, 2006. Jazwinski SM, H Warner, S Helfand, M Driscoll, DA Welsh, J Faulkner, N Barzilai, M Breitenbach, R McCarter, WT Brown, N Greco, J Mountz, SJ Olshansky, The Biological Sciences Section Program at the 57th Annual Meeting of The Gerontological Society of America, J. Gerontol. A Biol. Sci. Med. Sci 60:1359-1365, 2005. Pellett A, DA Welsh, B deBoisblanc, G Lipscomb, R Johnson, K Lord, J Cairo, J Zamjahn, M Levitzky, Low positive end-expiratory pressure does not exacerbate nebulized-acid lung injury in dogs, J Crit Care 20:97-105, 2005. Welsh DA, Thomas D, Obstructive Airway Disease, Pulmonary Pathophysiology. 2nd Ed. J Ali, WR Summer, MG Levitzky (editors). New York, McGraw Hill; pp 85-104, 2005. Guery BPH, Welsh DA, Viget N, Robriquet L, Fialdes P, Mason CM, Beaucaire G, Bagby G, and Neviere R, Ventilation-induced lung injury is associated with an increase in gut permeability, Shock 19:559-563, 2003. deBoisblanc BP, A Girod, DA Welsh, D Taylor, Hemodynamic Monitoring in ALI/ARDS, Respir Care Clinics North Am 9:457-479, 2003. Welsh DA, Mason, CM, Host defenses in respiratory infection, Med Clin North Am 85:1329-1347, 2001. Maher NH, SH Vermund, DA Welsh, HK Dillon, A Awooda, TR Unnasch, Development and characterization of a molecular viability assay for Pneumocystis carinii f. sp. hominis, J Infect Dis 183:1825-1827, 2001. Zhang P, GJ Bagby, JK Kolls, DA Welsh, WR Summer, J Andersen, S Nelson, The effects of granulocyte colony-stimulating factor and neutrophil recruitment on the pulmonary chemokine response to intratracheal endotoxin, J Infect Dis 165:458-465, 2000. Welsh DA, BPH Guery, EP Dobard, D Mercante, S Nelson, WR Summer, CM Mason, Keratinocyte growth factor attenuates hydrostatic pulmonary edema in a rat lung model, Am J Physiol 280:H1311-H1317, 2000. Welsh DA, WR Summer, EP Dobard, S Nelson, CM Mason, Keratinocyte growth factor prevents ventilator induced lung injury in an ex vivo rat lung model, Am J Respir Crit Care Med 162, 2000. Seoane L, deBoisblanc B, Shellito J, Welsh DA, HIV associated pulmonary hypertension: A review, S Med J 94:635-639, 2000. Welsh DA, Summer WR, de Boisblanc B, Thomas D, Hemodynamic consequences of mechanical ventilation, Clin Pulm Med 6:52-65, 1999. |
