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William C. Claycomb PhD |
Department of Biochemistry & Molecular Biology |
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| Click here for a link to ongoing research in this laboratory. | |
| Degrees: | PhD - 1969 |
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| Biography: |
Dr. Claycomb obtained his Bachelor of Science in Zoology from Indiana University in 1966. His Doctorate was awarded in 1969 from the Indiana University School of Medicine. From 1969 to 1972, Dr. Claycomb was a Research Associate at the Harvard Medical School in Biological Chemistry in Boston where he was a NIH postdoctoral fellow. From 1972 to 1976 he was an Assistant Professor at the Baylor College of Medicine in Houston. Dr. Claycomb then joined the faculty at LSUHSC as an Associate Professor and was an Established Investigator of the American Heart Association. He currently is Professor of Biochemistry and Molecular Biology at LSUHSC |
| Research Interests: |
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| Selected Publications: | Ikeda K, Tojo K, Inada Y, Takada Y, Sakamoto M, Lam M, Claycomb W, Tajima N.Regulation of urocortin I and its related peptide urocortin II by inflammatory and oxidative stresses in HL-1 cardiomyocytes. J Mol Endocrinol. 2009 Mar 24. Landstrom AP, Weisleder N, Batalden KB, Martijn Bos J, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ., Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans., J Mol Cell Cardiol. , 2007 Apr 18. Shimko VF, Claycomb WC., Effect of Mechanical Loading on Three-Dimensional Cultures of Embryonic Stem Cell-Derived Cardiomyocytes., Tissue Eng. Dec 18, 2007. Hidalgo-Bastida LA, Barry JJ, Everitt NM, Rose FR, Buttery LD, Hall IP, Claycomb WC, Shakesheff KM., Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering., Acta Biomater., Feb 26, (2007). George CH, Rogers SA, Bertrand BM, Tunwell RE, Thomas NL, Steele DS, Cox EV, Pepper C, Hazeel CJ, Claycomb WC, Lai FA., Alternative Splicing of Ryanodine Receptors Modulates Cardiomyocyte Ca2+ Signaling and Susceptibility to Apoptosis., Circ Res., Feb 22, (2007). Barnes K, Dobrzynski H, Foppolo S, Beal PR, Ismat F, Scullion ER, Sun L, Tellez J, Ritzel MW, Claycomb WC, Cass CE, Young JD, Billeter-Clark R, Boyett MR, Baldwin SA., Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH., Circ Res., Sep 1;99(5):510-9, (2006). White SM, Claycomb WC, Embryonic stem cells form an organized, functional cardiac conduction system in vitro, Am J Physiol Heart Circ Physiol., 288(2):H670-9., (2005). White SM, Constantin PE, Claycomb WC, Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function., Am J Physiol Heart Circ Physiol., Mar;286(3):H823-9, (2004). White SM, Claycomb WC, Cardiac cell transplantation: protocols and applications, Methods Mol Biol., 219:83-95, (2003). Lam ML, Bartoli M, Claycomb WC, The 21-day postnatal rat ventricular cardiac muscle cell in culture as an experimental model to study adult cardiomyocyte gene expression, Mol Cell Biochem., Jan;229(1-2):51-62, (2002). Lanson NA Jr, Egeland DB, Royals BA, Claycomb WC, The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 Cardiomyocytes, Nucleic Acids Res., 28:2882-2992, (2000). Claycomb WC, Lanson NA, Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A, Izzo NJ, HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte, Proc Natl Acad Sci USA, 95: 2979-2984, (1998). To search for all of Dr. Claycomb's publications click here.
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