Wayne Vedeckis


				Wayne V. Vedeckis PhD Amgen Professor of Oncology Department of Biochemistry & Molecular Biology 533 Bolivar St. Room 4B6 New Orleans, LA 70112 Phone: (504) 568-8175 Fax: 568-6997 wvedec@lsuhsc.edu Click here for a link to ongoing research in this laboratory.



	Biography:			Dr. Vedeckis obtained his Bachelor of Science in Biological Sciences from Loyola University in Chicago in 1970. His Doctorate in Biological Sciences was awarded in 1974 from Northwestern University in Evanston, IL. From 1974 to 1979, Dr. Vedeckis was an NIH postdoctoral fellow in the Department of Cell Biology at Baylor College of Medicine in Houston. During this time he began his research on the molecular mechanism of steroid hormone receptor action. Since 1979, he has been a faculty member in the Department of Biochemistry and Molecular Biology at LSUHSC in New Orleans, where he currently holds an appointment as the Amgen Professor of Oncology.

	Research Interests:			Steroid hormone action Structure, function, and genomic interactions of glucocorticoid receptor proteins Glucocorticoid mediated apoptosis


	Selected Publications			Geng CD, Vedeckis WV.A New, Lineage Specific, Autoup-Regulation Mechanism for Human Glucocorticoid Receptor Gene Expression in 697 Pre-B-Acute Lymphoblastic Leukemia Cells.Mol Endocrinol. 2010 Nov 17. [Epub ahead of print] Geng CD, Vedeckis WV. Use of Recombinant Cell-Permeable Small Peptides To Modulate Glucocorticoid Sensitivity of Acute Lymphoblastic Leukemia Cells.Biochemistry.Oct 19;49(41):8892-901; (2010) Open PDF of this article Schwartz JR, Sarvaiya PJ, and Vedeckis WV. Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia. Mol. Cell. Endocrinol. 320:76-86, (2010). Click here for abstract. Geng CD, Schwartz JR, Vedeckis WV. A conserved molecular mechanism is responsible for the auto-upregulation of glucocorticoid receptor gene promoters. Mol Endocrinol. Oct 22. (2008) Click here to view abstract. Geng CD, Vedeckis WV. C-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. J. Biol. Chem. 280:43264-43271, (2005). Click here to view abstract. Geng CD, Pedersen KB, Nunez BS, Vedeckis WV. Human glucocorticoid receptor a transcript splice variants with exon 2 deletions: evidence for tissue- and cell type-specific functions. Biochemistry 44:7395-7405, (2005). Click here to view abstract. Nunez BS, Geng CD, Pedersen KB, Millro-Macklin CD, Vedeckis WV. Interaction between the interferon signaling pathway and the human glucocorticoid receptor gene 1A promoter. Endocrinology 146: 1449-1457, (2005). Click here to view abstract. Pedersen, K.B., Geng, C.-d. and Vedeckis, W.V. (2004) Three mechanisms are involved in glucocorticoid receptor auto-regulation in a human T-lymphoblast cell line. Biochemistry 43: 10851-10858, (2004). Click here to view abstract. Geng CD, Vedeckis WV. Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter. Mol. Endocrinol.18:912-924, (2004). Click here to view abstract. Pedersen KB, Vedeckis WV. Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 42:10978-10990, (2003). Click here to view abstract. To do a search for all of Dr. Vedeckis' publications click here.

Department Home

contact webmaster I disclaimer I privacy policy