Edward Wojcik Ph.D.
Assistant Professor

Department of Biochemistry & Molecular Biology
1901 Perdido St., Box P7-2
Room MEB 7128
New Orleans, LA 70112

Phone: 504.568.2058
Lab: 504.568.2093
Fax: 568-6997

ewojci@lsuhsc.edu

Click here for a link to ongoing research in this laboratory.

NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site.  Learman SS, Kim CD, Stevens NS, Kim S, Wojcik EJ, Walker RA.   Biochemistry. 2009 Mar 3;48(8):1754-62.   

Allosteric drug discrimination is coupled to mechanochemical changes in the Kinesin-5 motor core.Kim ED, Buckley RS, Learman S, Richard J, Parke C, Worthylake DK, Wojcik EJ, Walker RA, Kim S.J Biol Chem. Mar 18. (2010)

ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism.Parke CL, Wojcik EJ, Kim S, Worthylake DK.J Biol Chem. Dec 15 (2009).

Raffa GD, Siriaco G, Cugusi S, Ciapponi L, Cenci G, Wojcik E, Gatti M., The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2271-6Jan 30 (2009)

Learman SS, Kim CD, Stevens NS, Kim S, Wojcik EJ, Walker RA. NSC 622124 Inhibits Human Eg5 and Other Kinesins via Interaction with the Conserved Microtubule-Binding Site (dagger). Biochemistry. (2009) Mar 3;48(8):1754-1762.

Raffa GD, Siriaco G, Cugusi S, Ciapponi L, Cenci G, Wojcik E, Gatti M. The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection.Proc Natl Acad Sci U S AFeb 17;106(7):2271-6. (2009) Jan 30.

A mitotic role for GSK-3beta kinase in Drosophila. Wojcik EJ. Cell Cycle. Dec 13;7(23) (2008)

Roykhman M, Ibach S, Harding D, Wolff B, Vowels M, Gelsthorpe ME, Wojcik EJ, Rizzo NP, Tsubota SI., The generation and analysis of deficiencies within a small genomic region on the X chromosome of Drosophila melanogaster containing two genes, enhancer of rudimentary and CG15352., Fly (Austin). Jul-Aug;1(4):245-50, 2007.

Basto R, Scaerou F, Mische S, Wojcik E, Lefebvre C, Gomes R, Hays T, Karess R., In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis., Curr Biol. 14(1), 2004.

Wojcik EJ, Dalrymple NA, Alford SR, Walker RA, Kim S., Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation., Biochemistry 43(31), 2004.

Wojcik E, Basto R, Serr M, Scaerou F, Karess R, Hays T., Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein., Nat Cell Biol. 3(11), 2001.

Wojcik EJ, Glover DM, Hays TS, The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila, Curr Biol. 10(18), 2000.

Robinson JT, Wojcik EJ, Sanders MA, McGrail M, Hays TS, Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila, J Cell Biol. 146(3), 1999

To do a search for all of Dr. Wojcik's publications click here.