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Thang Chiu Profile

Thang Chiu, PhD
Assistant Professor

Department of Biochemistry & Molecular Biology
1901 Perdido Street, Box P7-2
New Orleans, LA 70112
504.568.7117
Office MEB 7E1/7156
Lab Phone 504.568.2024
tchiu@lsuhsc.edu

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		Department of Biochemistry and Molecular Biology LSU School of Medicine 1901 Perdido Street Room 7101 New Orleans, LA 70112 (504) 568-4733

Biography:
Dr. Chiu obtained his Bachelor of Science in Biochemistry and General Physics from the University of California, Los Angeles in 1992. He received his PhD in Biochemistry and Molecular Biology from the University of California, Los Angeles in 2001. From 2001 to 2007 he worked in the Lab of Molecular Biology at the National Institutes of Health, NIDDK.

From 2004 to 2007 he organized weekly research seminars among the X-ray crystallography groups. He is now an Assistant Professor for the Department of Biochemistry and Molecular Biology at Louisiana Health Sciences Center at New Orleans. His research interests are crystallographic and biochemical studies of proteins involved in HIV/AIDS, diabetes and innate immunity; protein folding, and the role of conformational changes on protein structure and function.

Selected Publications

J Kubelka, TK Chiu, DR Davies, WA Eaton, and J Hofrichter. Sub-microsecond Protein Folding. J.Mol. Biol., 2006, 359, 546-553.

TK Chiu and DR Davies. Structure and Function of HIV-1 Integrase: An Update. Frontiers in Medicinal Chemistry, 2006, 3, 3-22. Editors: Atta-ur-Rahman and Allen B. Reitz, Bentham Science Publishers LTD. (Book chapter)

U Baxa, N Cheng, DC Winkler, TK Chiu, DR Davies, D Sharma, H Inouye, DA Kirschner, RB Wickner, and AC Steven. Filaments of the Ure2p Prion Protein have a Cross-b Core Structure. J. Structural Biology., 2005, 150, 170-179.

TK Chiu, J Kubelka, R Herbst-Irmer, WA Eaton, J Hofrichter, and DR Davies. High-resolution X-ray Crystal Structures of the Villin Headpiece Subdomain, an Ultrafast Folding Protein. Proc. Nat. Acad. Sci., 2005, 102, 7517-7522.
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TK Chiu and DR Davies. Structure and Function of HIV-1 Integrase. Current Topics in Medicinal Chemistry, 2004, 4, 965-979.

TK Chiu, C Sohn, RE Dickerson, and RC Johnson. Testing Water-mediated DNA Recognition by the Hin Recombinase. EMBO J., 2002, 21, 801-814.

DR Mack, TK Chiu and RE Dickerson. Intrinsic Bending and Deformability at the T-A Step of CCTTTAAAGG: A Comparative Analysis of T-A and A-T Steps within A-tracts. J. Mol. Biol., 2001, 312, 1037-1049.

TK Chiu and RE Dickerson. 1Å Crystal Structures of B-DNA Reveal Sequence-Specific Binding and Groove-Specific Bending of DNA by Magnesium and Calcium. J. Mol. Biol., 2000, 301, 915-945.

TK Chiu, MK Grzeskowiak and RE Dickerson. Absence of Minor Groove Monovalent Cations in the Crosslinked Dodecamer CGCGAATTCGCG. J. Mol. Biol., 1999, 292, 589-608.

ML Kopka, GW Han, DS Goodsell, TK Chiu, WL Walker, JW Lown, and RE Dickerson. DNA Sequence Recognition in the Minor Groove by Polyamides, Using a GC-Specific Reading Element: A Perspective from Crystallography. Proceedings of the Tenth Conversation, State University of New York, Albany, NY. 1998, 177-191.

RE Dickerson and TK Chiu. Helix Bending as a Role in Protein/DNA Recognition. Biopolymers: Nucleic Acid Sciences, 1997, 44, 361-403.

ML Kopka, DS Goodsell, GW Han, TK Chiu, JW Lown, and RE Dickerson. Defining GC-Specificity in the Minor Groove: Side-by-Side Binding of the Diimidazole Lexitropsin to CATGGCCATG. Structure, 1997, 5, 1033-1046.

ZS Juo, TK Chiu, PM Leiberman, I Baikalov, AJ Berk, and RE Dickerson. How Proteins Recognize the TATA Box. J. Mol. Biol., 1996, 261, 239-254.

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