Wayne V. Vedeckis, Ph.D.

Professor Emeritus

Department of Biochemistry & Molecular Biology

wvedec@lsuhsc.edu

Click here for a link to ongoing research in this laboratory.

Bio

Dr. Vedeckis obtained his Bachelor of Science in Biological Sciences from Loyola University in Chicago in 1970. His Doctorate in Biological Sciences was awarded in 1974 from Northwestern University in Evanston, IL. From 1974 to 1979, Dr. Vedeckis was an NIH postdoctoral fellow in the Department of Cell Biology at Baylor College of Medicine in Houston. During this time he began his research on the molecular mechanism of steroid hormone receptor action. Since 1979, he has been a faculty member in the Department of Biochemistry and Molecular Biology at LSUHSC in New Orleans.

Research Interests Steroid hormone action
structure, function, and genomic interactions of glucocorticoid receptor proteins
steroid hormone regulation of proto-oncogene expression and cellular proliferation
Leukemia
Selected Publications

Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells. Miller AL, Geng C, Golovko G, Sharma M, Schwartz JR, Yan J, Sowers L, Widger WR, Fofanov Y, Vedeckis WV, Thompson EB. Cancer Cell Int. 2014 Apr 23;14:35. doi: 10.1186/1475-2867-14-35. eCollection 2014. PMID: 24795534

Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis. Sarvaiya PJ, Schwartz JR, Hernandez CP, Rodriguez PC, Vedeckis WV. Am J Hematol. 2012 Oct;87(10):969-76. doi: 10.1002/ajh.23283. Epub 2012 Jul 5. PMID: 22764095

A facile, branched DNA assay to quantitatively measure glucocorticoid receptor auto-regulation in T-cell acute lymphoblastic leukemia. Schwartz JR, Sarvaiya PJ, Leiva LE, Velez MC, Singleton TC, Yu LC, Vedeckis WV. Chin J Cancer. 2012 Aug;31(8):381-91. doi: 10.5732/cjc.012.10044. Epub 2012 Jun 26. PMID: 22739263

c-Myb interacts with the glucocorticoid receptor and regulates its level in pre-B-acute lymphoblastic leukemia cells. Sarvaiya PJ, Schwartz JR, Geng CD, Vedeckis WV. Mol Cell Endocrinol. 2012 Sep 25;361(1-2):124-32. doi: 10.1016/j.mce.2012.03.024. Epub 2012 Apr 10. PMID: 22516378

A new, lineage specific, autoup-regulation mechanism for human glucocorticoid receptor gene expression in 697 pre-B-acute lymphoblastic leukemia cells. Geng CD, Vedeckis WV. Mol Endocrinol. 2011 Jan;25(1):44-57. doi: 10.1210/me.2010-0249. Epub 2010 Nov 17. PMID: 21084380