School of Medicine

Biochemistry

 

Liu, L; Richard, J; Kim, S; Wojcik, EJ. Small-molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5. Journal of Biological Chemistry 289, 16601-16614

Buckley, R; Richard, J; Huckaba, TM; Wojcik, EJ; Kim, S. Kif11 kinesin. Gene Wikipedia (online)

Wojcik, EJ; Buckley, R; Richard, J; Huckaba, TM; Kim, S. Kinesin-5: cross-bridging mechanism to targeted clinical therapy.Gene 531, 133-149

Liu, L; Parameswaran, S; Liu, J; Kim, S; Wojcik, EJ. Loop 5-directed compounds inhibit chimeric Kinesin-5 motors:  implications for conserved allosteric mechanisms.  Journal of Biological Chemistry 286, 6201-6210

Kim, ED; Buckley, R; Learman, S; Richard, J; Parke, C; Worthylake, DK; Wojcik, EJ; Walker, RA; Kim, S. Allosteric drug discrimination is coupled to mechanochemical changes in the Kinesin-5 motor core.  Journal of Biological Chemistry 285, 18650-18661

Jun, B; Kim, S. Real-time conformational transitions are coupled to chemical steps in ATP hydrolysis by human Kinesin-5.  Journal of Biological Chemistry 285, 11073-11077

Parke, C; Wojcik, EJ; Kim, S; Worthylake, D.  (2010) ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism.Journal of Biological Chemistry 285, 5859-5867 [JBC paper of the week, citation by Faculty of 1000 Biology as a ‘must read' paper]

Learman, S; Kim, C; Stevens, NS; Kim, S; Wojcik, EJ; Walker, RA. (2009) NSC 622124 inhibits human Eg5 and other kinesins via binding to the conserved microtubule-binding site.  Biochemistry 48, 1754-1762

Wojcik, EJ; Dalrymple, NA; Alford, SA; Walker, RA; Kim, S. (2004) Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a FT-IR investigation. Biochemistry 43, 9939-9949

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