Dr. Suresh K. Alahari
— Associate Professor
Performs research investigating the role of Nischarin in breast tumor progression. Current studies are identifying proteins that interact with Nischarin in breast cancer cells using proteomics as well as yeast two-hybrid approaches. A detailed understanding of the mechanistic basis of tumor cell migration and invasion can significantly advance the development of new therapeutics that stop tumor growth and metastasis. Click here to learn more about Dr. Alahari's research.
Dr. Arthur L. Haas
— Professor and Chairman
Ubiquitin conjugation targets proteins for degradation. Ubiquitin conjugation is a fundamental cellular process that has been implicated in gene regulation, DNA repair, stress response, cell cycle progression, various forms of muscle atrophy, and Alzheimers dementia. Dr. Haas has identified a second constitutive system within cells that is parallel but distinct from ubiquitin in which the 15 kDa interferon-like protein ISG15/UCRP is conjugated to a smaller subset of intracellular targets. The conjugation of ISG15 to intracellular targets functions to regulate protein-protein interactions. The Haas laboratory is interested in characterization of the enzymes involved in the respective conjugation reactions; structure-function analysis of these enzymes; and examining the roles of ubiquitin and ISG15 conjugation in cellular regulation. Click here to learn more about Dr. Haas's research.