Pediatric Hematology and Oncology Trials

For more information, contact:
Lolie Yu, MPH, MD, at (504) 896-9740
Stephanie Sonnier, RN, at (504) 894-5377

Biology Studies

COG AREN03B2: Children's Oncology Group Renal Tumors Classification, Biology and Banking Study 

ACNS02B3: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens 

COG ANBL00B1: Neuroblastoma Biology Studies

COG ABTR06C1: Pharmacokinetics of Daunomycin in Children

Hematopoietic Stem Cell Transplant

Pilot Study of Unrelated Umbilical Cord Blood Transplantation in Children with Bone Marrow Failure Syndromes or Inherited Metabolic or Hematologic Disease 

National Marrow Donor Program (NMDP) Research Database for Allogeneic Unrelated Hematopoietic Stem Cell Transplantation and Marrow Toxic Injuries 

COG AEWS 0331: European Ewing Tumor Working Initiative of National Groups Ewing Tumor Studies 1999 (EURO-E.W.I.N.G. 99) 

Investigation of HLA-matched, Related, Human Umbilical Cord Blood Transplantation for the Treatment of Symptomatic Sickle Cell Disease or Beta-Thalassemia Major in Children 

COG ASCT0521: Soluble Tumor Necrosis Factor Receptor: Enbrel (Entanercept) for the Treatment of Acute Non-infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) Following Allogeneic Stem Cell Transplantation 

A Pilot Study of Unrelated Umbilical Cord Blood Transplantation in Children with Hematologic Malignancies 

Selection of CD34+ Cells for Stem Cell Transplantation of Hematologic Malignancies 

A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease Using a Non-Myeloablative Preparatory Regimen with Campath-1H, Fludarabine and Melphalan

COG 0501: Multicenter, Open Label, Randomized Trial Comparing Single versus Double Umbilical Cord Blood (UCB) Transplantation in Pediatric Patients with Leukemia and Myelopdysplasis (BMT CTN 0501)

Treatment Protocol to Evaluate Safety and Treatment Outcomes of Prochymal (Ex-Vivo Cultured Adult Human Mesenchymal Stem Cells) Infusion for the Treatment of Steroid-Refractory Acute GVHD in Pediatric Patients

Brain

ANBL0421: A Phase II Study of Irinotecan + Temozolomide in Children with Recurrent Neuroblastoma 

ACNS0331: A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18.00Gy) and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial 

ANBLOOP2: Perinatal Neuroblastoma: Expectant Observation (A COG Pilot Study) Alternative, Non-Observational Arm 

ANBL 0032: Phase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue

ANBL0532: Phase III Randomized Trial of Single vs. Tandem Myeloablative Consolidation Therapy for High-Risk Neuroblastoma

Leukemia

COG AALL03N1: Understanding the Ethnic and Racial Differences in Survival in Children with Acute Lymphoblastic Leukemia 

Use of High Dose Cytosine Arabinoside (ARA-C), Cyclophosphamide, Total Body Irradiation and Marrow Transplantation as Treatment for Patients with Acute Lymphoblastic Leukemia 

COG AALL03B1: Classification of Acute Lymphoblastic Leukemia 

AALL0232: High Risk B-Precursor Acute Lymphoblastic Leukemia 

AALL0331: Standard Risk B-precursor Acute Lymphoblastic Leukemia 

COG AALL0434: Intensified Methotrexate, Nelarabine (Compound 506U78; IND #52611) and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell Acute Lymphoblastic Leukemia (ALL)

ASCT0431: A Randomized Trial of Sirolimus-Based Graft versus Host Disease Prophylaxis after Hematopoietic Stem Cell Transplantation in Relapsed ALL
 

Lymphoma

COG AHOD0431: A Phase III Study for the Treatment of Children and Adolescents with Newly Diagnosed Low Risk Hodgkin Disease 
 

Sarcoma

COG AOST0331: Randomized Trial of the European and American Osteosarcoma Study Group to Optimize Treatment Strategies for Resectable Osteosarcoma Based on Histological Response to Pre-Operative Chemotherapy 

COG ARST0431: Intensive Multi-Agent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide (IE) and Vincristine/Doxorubicin/Cyclophosmamide (VDC) for Patients with High-Risk Rhabdomyosarcoma

ARST0531: Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS)

Sickle Cell or Beta Thalassemia Major

One Year Open-label, Non-comparative Extension to a Randomized, Multicenter, Phase II Study to Evaluate the Safety and Tolerability, Pharmacokinetics and the Effects on Liver Iron Concentration of Repeated Doses of 5-30 mg/kg/day of ICL670 Relative to Deferoxamine in Sickle Cell Disease Patients with Transfusional Hemosiderosis (Protocol # CICL670A0109E1) 
Contact: Cercre Spence, RN at 504-894-5377 

Study of the Significance of Arginine Deficiency on Immune Status in Sickle Cell Disease 
 

Miscellaneous

COG ABTR01B1: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors 

ALTE03N1: Key Adverse Events After Childhood Cancer 

COG AEPI041C1: Low Birth Weight and Other Risk Factors for Heptoblastoma

A Single Arm Study to Assess the Safety of Transplantation with Umbilical Cord Blood Augmented with Human Placental-Derived Stem Cells from Partially or Fully-Matched Related Donors in Subjects with Certain Malignant Hematologic Diseases and Non-Malignant Disorders

ACCL05C1: A Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy

COG ACCRN07: Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network (CCRN)

An Open Label Intravenous to Oral Switch, Multiple Dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Voriconazole in Immunocompromised Adolescents Aged 12 to <17 Years Who Are At High Risk for Systemic Fungal Infection

Wilms

AREN0532: Treatment for Very Low and Standard Risk Favorable Histology Wilms Tumor