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Thomas Lallier, PhD

Associate Professor of Cell Biology and Anatomy

LSUHSC Dental School
1100 Florida Avenue
New Orleans, LA 70112
Phone: (504) 619-8719
Fax: (504) 619-8741

tlalli@lsuhsc.edu

Degrees

BA Biology - 1985
University of Virginia, Charlottesville, VA

PhD Developmental and Cell Biology - 1991
University of California, Irvine, CA

Bio

Research


Dr. Lallier and his laboratory are interested in elucidating the molecular mechanisms of cell migration. These involve the ability of cells to dynamically regulate their mechanical contacts with other cells and with the extracellular matrix (ECM). They are focusing upon the cell movements involved with the morphogenesis of early Xenopus embryos. Current research focuses on two aspects of cellular migration: 1) molecules responsible for cell attachment to the ECM; and 2) molecules which regulate cell attachment and guidance. Dr. Lallier and his lab have focused their attention upon cell interactions with laminin (an ECM component involved in epithelia formation and axon guidance) and its cell surface receptors (specifically the a6 subunit of integrin). They are presently studying the interaction between these molecules in neurulation, neural crest cell migration, axon guidance, and pronephric duct formation. They are also investigating the role of semaphorins (collapsins) in setting up the initial tissue pattern within the Xenopus embryo. The lab will also be investigating how semaphorin induces guidance in directing axon guidance as well as cell migrations of the neural crest cell and the pronephros. These experiments will be performed in vivo, by over-expressing and under-expressing various members of the semaphorin family within the living embryo.

Teaching Activities Research Methodologies, LSUSD
Molecular Structure and Function of the Cell
Concepts in Cell & Developmental Biology
General and Oral Histology, LSUSD
Developmental Neuroscience
Molecular Neuroscience
Advanced Oral Biology, LSUSD
Committees & Administrative Responsibilities Departmental Graduate Student Committee, LSUHSC
Graduate Advisory Council, LSUHSC
Council on Professional Conduct, LSUHSC
Radiation Safety Committee, LSUHSC
President Elect, Faculty Assembly, LSUSD
Chair, Research Day Committee, LSUSD
Chair, Student Research Committee, LSUSD
Advisory Committee, Master of Science in Oral Biology, LSUSD
Basic Science Subcommittee, Curriculum Committee, LSUSD
Curriculum Committee, LSUSD
Co-Director of Research Core Facilities, LSUSD
Assistant Director, Center of Excellence in Oral and Craniofacial Biology, LSUSD
Coordinator for Student Research, LSUSD
Selected Publications

Lallier, T.E., Specer, A.Y. and Fowler, M.M., Transcript Profiling of Periodontal Fibroblasts and Osteoblasts, J Dent Res. resubmitted, 2003.

Bonson, S., Jeansonne, B.G., and Lallier, T. E., Root End-filling Materials alter Fibroblast Differentiation, J. Dent Res (in revision), 2003.

Lallier, T.E., Semaphorin Profiling of Periodontal Fibroblasts and Osteoblasts, J. Dent. Res. (submitted), 2003.

Lallier, T. E., Palaiologou, A.A., Yukna, R.A., and Layman, D., P-15 Promotes Fibroblast Attachment To Root Shavings, J. Periodontology 74(4): 458-467, 2003.

Camp, M., Jeansonne, B.G, and Lallier, T.E., The Adhesion of Human Fibroblasts to Root-End Filling Materials, J Endodontics 29(9):602-607, 2003.