Tomoo Iwakuma, MD, PhD

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	Tomoo Iwakuma, MD, PhD Assistant Professor of Genetics Department of Genetics/Cancer Center Room 439, 533 Bolivar Street Louisiana State University Health Sciences Center New Orleans, LA 70112 Phone: (504) 568-3235 Fax: (504)568-8500 tiwaku@lsuhsc.edu
Degrees	MD - 1991 Kyushu University in Japan PhD - 1997 Kyushu University in Japan
Bio	Dr. Iwakuma received an M.D. at Kyushu University in Japan, majoring in Orthopedics. He received his Ph.D. at the Department of Biochemistry at the same University. He spent several years as a research fellow studying gene therapy, pharmacology, and molecular genetics in different laboratories. Following Dr. Guillermina Lozanos laboratory at the Department of Molecular Genetics at the University of Texas M.D. Anderson Cancer Center, he joined LSU, Department of Genetics/Cancer Center, as an assistant professor as of August 15, 2005. Dr. Iwakumas primary research focuses on the field of Cancer Research, especially modeling human cancers in mice, dissecting protein function in tumor suppressor p53 pathway, and applying disease models to translational research, to ultimately cure cancer.
Research Interests	Functional analysis of proteins on p53 pathway Mouse models of cancer
Selected Publications	Adhikari A, Iwakuma T. Mutant p53 gain of oncogenic function: in vivo* evidence, mechanism of action and its clinical implications. Fukuoka Acta Medica2009. In press. Busso CS, Iwakuma T, Izumi T. Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene 2009, 28(13):1616-1625. Barboza JA, Iwakuma T, Terzian T., El-Naggar AK, Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Molecular Cancer Res. 2008, 6(6): 947-954. Terzian T, Suh Y-A, Iwakuma T, Post SM, Neumann M, Lang GA, Van Pelt CS, Lozano G. The inherent instability of mutant p53 is alleviated by Mdm2 or p16^INK4a loss. Genes & Development 2008, 22(10): 1337-1344. *Iwakuma T ,** Tochigi Y, Van Pelt CS, Caldwell LC, Terzian T, Parant JM, Chau GP, Koch J, Eischen CM, Lozano G.. Mtbp* haploinsufficiency in mice increases tumor metastasis. Oncogene 2008, 27(13):1813-1820. Co-corresponding authors. Iwakuma T* , Lozano G,, Crippling p53 activities via knockin mutations in mouse models., Oncogene , 2007, in press..
Additional Info	Tomoo Iwakuma, M.D., PhD, Biosketch

Assistant Professor of Genetics