Doan H. Nguyen, PhD

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	Doan H. Nguyen, PhD Director, Microarray and Genome Bioinformatics Center, Gene Therapy Program Instructor, Department of Genetics and Ophthalmology LSU Health Sciences Center 533 Bolivar St., Rm 539 CSRB New Orleans, LA 70112 Phone: (504) 568-4552 Fax: (504) 568-8500 dnguye@lsuhsc.edu
Degrees	BS Biology - 1989 University of Illinois-Urbana Champaign PhD Department of Cell Biology and Anatomy - 1997 LSU Health Sciences Center, New Orleans
Bio	After receiving a BS in Biology from the University of Illinois, Doan volunteered with the US Peace Corps and spent over two years in Nepal as a science/math educator and trainer. He received his PhD in Cell Biology and Anatomy from LSUHSC in New Orleans where he also did a post-doctoral fellowship in the Department of Ophthalmology. In 2002, he became a Research Instructor in the Department of Ophthalmology. In 2007, he joined the Department of Genetics as an Instructor and Director of the Microarray and Genome Bioinformatics Center, LSU Gene Therapy Program. The major research focus of this laboratory is aging of the lacrimal gland using the Fischer 344 rat model of aging. The lacrimal gland is a major contributor of proteins and fluid to the water layer of the tear film. The tear film is critical to the optical quality of the cornea and, therefore, vision. It helps maintain the cellular structure of the ocular surface, as well as protects the cornea from pathogens. Lacrimal gland secretion is under neural control and the neural circuit that links the cornea to the gland is important for the maintenance of lacrimal gland structure and function. With age, corneal sensation is decreased, hence the neural input to stimulating secretion from the gland is affected leading to changes in lacrimal gland function which affect the integrity of the ocular surface. Doans laboratory developed a rat dry eye model by disrupting the parasympathetic stimulation of secretion. The model exhibited many symptoms associated with dry eye syndrome. Gene2Function: we are developing a web service for the mapping of genes to public databases. Users also have the option to upload and share their own database with colleagues, as well as map-enabling their database. Also in the pipeline is the ability to extract, format, and download literature information from the input gene list from microarray experiments. This research is supported by grants from the NIH NCCR and the Louisiana Biological Research Network (LBRN) entitled LACRIMAL GLAND BIOINFORMATICS: A Neural Connection of Dry Eye and Aging
Research Interests	Bioinformatics DNA microarray Aging and dry eye
Selected Publications	Nguyen DH, Valadamu V, Toshida H, Beuerman RW, Loss of parasympathetic innervation leads to sustained expression of pro-inflammatory genes in the rat lacrimal gland, Auton Neurosci 124(1-2): 81-9, 2006. Nguyen DH, Beuerman RW, Meneray MA, Toshida H, Sensory denervation modulates eIF-2 kinase expression in the rabbit lacrimal gland, Curr Eye Res 31(4): 287-95, 2006.
Additional Info	Doan Nguyen, PhD Curriculum Vitae

Director, Microarray and Genome Bioinformatics Center, Gene Therapy Program Instructor, Department of Genetics and Ophthalmology

Director, Microarray and Genome Bioinformatics Center, Gene Therapy Program
Instructor, Department of Genetics and Ophthalmology