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LSU Health New Orleans 
Mingquan (Michael) Zheng, M.D.
Mingquan (Michael) Zheng, M.D.
Associate Professor of Research
Associate Professor of Research
533 Bolivar Street
New Orleans, LA 70112
Phone: (504) 568-2133
Fax: (504) 568-8500
Degrees
M.D. 1986
Xinjiang Medical College
Urumqi, Xinjiang, China
Bio
Dr. Zheng graduated in 1986 from Xinjiang Medical College in China with his M.D. He did his postdoctoral training in both physiology and immunology at LSU Health Sciences Center in New Orleans. In 2003, Dr. Zheng accepted a position as a junior faculty member at the University of Pittsburgh. In 2009, Dr. Zheng returned to LSU Health Sciences Center in New Orleans as an Assistant Professor in the Department of Genetics.
Dr. Zheng’s research is focused on lung host defenses against lung infection diseases. He is investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung. He is focus studying Th 17 cell signaling in lung infection disease model and smoke model as well. Dr. Zheng is also developing CD4-independent vaccination against AIDS-related opportunistic infections and influenza. He has a long-standing interest in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer.
Research Interests
The major goal of my research is to investigate mechanisms of lung host defenses in normal and immunocompromised hosts. We are developing CD4-independent vaccination against AIDS-related opportunistic infections and influenza. We are also investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung. We have a long-standing interest in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer.
Selected Publications
Rapaka RR, Alcorn JF, Khader SA, Zheng M, Plevy S, Bengten E, and Kolls JK. Conserved natural IgM antibodies mediate innate and adaptive immune responses and host defense against opportunistic fungi. (submitted)
Mingquan Zheng, Rekha Rapaka, Euan A Lockhart, Alistair Ramsay, Judd E. Shellito, Julie Bindas, Theresa Dubowski, Chad Steele, and Jay K Kolls. IL-23 Dependent Immune Responses in Dendritic Cell-Based Vaccination in Mice. (submitted)
Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T, Mak TW, Clifton MC, Strong RK, Ray P, Kolls JK. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J. Immuol. 2009 Apr 15;182(8):4947-56.
Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nature Medicine14, 275 - 281 (2008)
Zhang Z, Zheng M, Bindas J, Schwarzenberger P, Kolls JK. Critical Role of IL-17 Receptor Signaling in Acute TNBS-induced Colitis. Inflamm Bowel Dis. 2006 May;12(5):382-388.