Andrew Hollenbach, PhD

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	Andrew Hollenbach, PhD Assistant Professorof Genetics 533 Bolivar Street New Orleans, LA 70112 Phone: (504) 568-2431 Fax: (504) 568-8500 aholle@lsuhsc.edu
Degrees	BS Chemistry - 1989 University of Delaware, Newark, Delaware PhD Biochemistry - 1994 Johns Hopkins University, Baltimore, MD
Bio	Dr. Hollenbach received his Bachelor of Science degree in Chemistry from the University of Delaware in 1989 and his Doctor of Philosophy degree in Biochemistry from Johns Hopkins University in 1994.Dr. Hollenbach conducted his postdoctoral training in the lab of Dr. Gerard Grosveld at St. Jude Childrens Research Hospital in Memphis, TN, and was subsequently promoted to a junior faculty position in 2001.Dr. Hollenbach accepted a position as an Assistant Professor in the Department of Genetics at LSUHSC in April 2003 where he is also a member of the Stanley S. Scott Cancer Center. Dr. Hollenbachs research focuses on understanding the cell biological mechanisms underlying the formation of the childhood solid muscle tumor alveolar rhabdomyosarcoma (ARMS).ARMS are characterized by the presence of the t(2;13) reciprocal chromosomal translocation that results in the oncogenic fusion protein, Pax3-FKHR.Dr. Hollenbach is interested in elucidating how the presence of Pax3-FKHR alters the normal functions and regulation of wild-type Pax3, a transcription factor required for muscle development.Current projects in the Hollenbach lab include determining the role of phosphorylation on the biological and biochemical functions of Pax3 and Pax3-FKHR, and examining the regulation of Pax3 and Pax3-FKHR through protein-protein interactions.
Research Interests	Regulation of transcription factors through phosphorylation Biochemical mechanisms of chromosomal translocation gene products in cancer formation
Selected Publications	Sidhu, A., Miller, P. J., and Hollenbach, A. D. (2009) “Transcriptional regulation of the acute phase protein ceruloplasmin by FOXO1a” J. Mol. Biol. (manuscript in revision) Miller, P. J., Dietz, K. N., and Hollenbach, A. D. (2008) Identification of serine 205 as a site of phosphorylation on Pax3 in proliferating but not differentiating primary myoblasts. Protein Sci 17:1979-86. Sidhu, A., Miller, P. J., Johanson, K. E., and Hollenbach, A. D. (2008) Novel flanking DNA sequences enhance FOXO1a DNA binding affinity but do not alter DNA bending. Biochemistry 47:6809-18. Bakkar, N., Wang, J., Ledner, K. J., Wang, H., Dahlman, J., Carathers, M., Acharyya, S., Rudnicki, M. A., Hollenbach, A. D., and Guttridge, D. C. (2008) “IKK/NF-kB Regulates Skeletal Myogenesis Via a Signaling Switch to Inhibit Differentiation and Promote Mitochondrial Biogenesis” J. Cell Biol. 180(4), 787 – 802. Miller, P. J. and Hollenbach, A. D. (2007) “The oncogenic fusion protein Pax3-FKHR has a greater post-translational stability relative to Pax3 during early myogenesis” Biochim. Biophys. Acta 1770(10), 1450 – 1458.
Additional Info	Andrew Hollenbach, PhD, Biosketch

Assistant Professorof Genetics