Jay K. Kolls, M.D.

Administration	Basic Sciences	Clinical Sciences	Centers of Excellence
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	Jay K. Kolls, M.D. Chair, Genetics 533 Bolivar Street New Orleans, LA 70112 Phone: (504) 568-6117 Fax: (504) 568-8500 jkolls@lsuhsc.edu
Degrees	BS, Physics, 1981 Ursinus College Collegeville, Pennsylvania M.D., 1985 University of Maryland School of Medicine Baltimore, Maryland
Research Interests	The major goal of my research is to investigate mechanisms of lung host defenses in normal and immunocompromised hosts. Presently, we are investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung. To this end we study cellular sources of IL-17A, IL-17F, and IL-22 in the lung as well as their signaling in response to pulmonary infection. We also have long standing interest to determine if Th17 cells and their cytokine products contribute to airway destruction in cystic fibrosis. We also have a long-standing interest in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer. In these studies we have identified that sub-populations of CD8+ T-cells polarized in vivo via cytokine gene transfer have effector activity against P. carinii. We are presently using gene expression profiling and proteomics to define this effector activity. We also have a program in developing CD4-independent vaccination against AIDS-related opportunistic infections. Current Research interest Keywords: gene therapy, lung immunology, lung host defenses, tumor necrosis factor, pneumonia, pneumocystis carinii pneumonia, ethanol, gene expression, polymerase chain reaction, molecular biology
Committees & Administrative Responsibilities	Editorial Board: Respiratory Research Section Editor, Journal of Immunology Consulting Editor, Journal of Clinical Investigation
Selected Publications	Chan YR, Liu J, Pociask D, Zheng M, Mietzner TA, Berger T, Mak T, Clifton M, Strong RK, Ray P, Kolls JK. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J. Immuol. 2009 (in press). Kreindler JL, Bertrand CA, Lee RJ, Karasic T, Aujla S, Pilewski JM, Frizzell RA, Kolls JK. Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 Dec 12. Kolls JK, McCray PB Jr, Chan YR. Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol. 2008 Nov;8(11):829-35. McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol. 2008 Sep 15;181(6):4089-97. Zhao XJ, Dong Q, Bindas J, Piganelli JD, Magill A, Reiser J, Kolls JK. TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol. J Immunol. 2008 Sep 1;181(5):3049-56. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 2008 Apr;28(4):454-67. Raffatellu M, Santos RL, Verhoeven D, Wilson RP, Winter SE, Godinez I, Sankaran S, Paixao T, George MD, Gordon MA, Kolls JK, Dandekar S, and Bäumler AJ. IL-17 orchestrates a mucosal response against Salmonella dissemination from the gut.. Nat Med. 2008 Apr;14(4):421-8. Aujla S, Chan YC, Zheng M, Fei M, Askew DJ, Pociask DA , Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, and Kolls JK. IL-22 mediates mucosal host defense against gram negative bacterial pneumonia. Nat Med. 2008 Mar;14(3):275-81.
Additional Info	Jay Kolls, M.D., Curriculum Vitae

Chair, Genetics