Jakob Reiser, PhD

Associate Professor, Medicine

533 Bolivar Street, Room 601
New Orleans, LA 70112
Phone: (504) 568-6152
Fax: (504) 568-8500

jreise@lsuhsc.edu

Website

Degrees

PhD Biochemistry (magna cum laude) - 1976
Biozentrum, University of Basel

Bio

We are working on the design of improved lentivirus-based gene delivery systems to treat neurological disorders including lysosomal storage diseases. We are also working on the design of novel lentiviral vectors to trap genes and proteins to allow real-time analysis of gene and protein expression patterns in mammalian cells to identify pathways and genes involved in disease states.

Research Interests

Lentivirus-based vectors
Vector targeting
CNS disorders (Krabbe disease)
Global protein delivery
Virus evolution
Gene trap vectors

Research page

Selected Publications

Pluta, K., M.J. Luce, L. Bao, S. Agha-Mohammadi and J. Reiser. Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters. Journal of Gene Medicine 7, 803-817 (2005).

 

Cronin, J., X.-Y. Zhang and J. Reiser. Altering the tropism of lentiviral vectors through pseudotyping. Current Gene Therapy 5, 387-398 (2005).

 


Bialkowska, A., X.-Y. Zhang and J. Reiser. Improved tagging strategy for protein identification in mammalian cells. BMC Genomics 6: 113 (2005).

 


Yang, G., Q. Zhong, W. Huang, J. Reiser and P. Schwarzenberger. Retrovirus molecular conjugates: a versatile and efficient gene transfer vector system for primitive human hematopoietic progenitor cells. Cancer Gene Therapy 13, 460-468 (2006).

 


Song,Y., Z. Zhang, X. Yu, M. Yan, X. Zhang, S. Gu, T. Stuart, C. Liu, Y. Zhang, J. Reiser and YiPing Chen. Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. Developmental Dynamics 235, 1347-1357 (2006).

 


Bahner, I., T. Sumiyoshi, M. Kagoda, R. Swartout, K. Pepper, D. Peterson, F. Dorey, J. Reiser and D. B. Kohn. Lentiviral Vector Transduction of a Dominant-Negative Rev Gene Into Human CD34(+) Hematopoietic Progenitor Cells Potently Inhibits HIV-1 Replication. Molecular Therapy 15, 76-85 (2007).

 

Additional Info

Publications at PubMed