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René Anand Nicotinic AchR subunits have relatively large cytoplasmic domains their third and fourth transmembrane domains.  In muscle type AchRs subunits, these domains have been shown to be the sites of interaction for at least one structural protein (43K protein) involved in clustering these AchRs.  The amino acid sequence of this domain is highly variable between the various cloned AchR subunits.  By analogy with muscle type AchRs, these domains are likely to play a role in determining the final destination of AchR subtype's in the CNS.  Proteins that interact with these domains of the neuronal AchR subunits and mediate their synaptic targeting have not been identified thus far.  My plan is to use both interaction cloning (yeast two-hybrid cloning system) and biochemical purification techniques to identify and characterize novel structural and regulatory proteins that interact with the large cytoplasmic domain of nicotinic AchR subunits.  This work will provide insight into neuronal proteins that target and anchor AchRs to synaptic subsites.

 

Bruce Fisch Functional neuroanatomy, clinical epilepsy, signal analysis of central nervous system electrical activity, clinical neurophysiology of sleep

 

Harry J. Gould Basic mechanisms of pain

 

Leo T. Happel Electrical characteristics of regenerating nerve; peripheral nerve lesions; membrane electrophysiology

 

Piotr W. Olejniczak Functional neuroanatomy, pathophysiology of epilepsy, computerized signal analysis of nervous system electrical activity; sleep physiology

 

Jayaraman Rao Neurochemical organization of the basal ganglia; animal models of Parkinson’s disease; clinical aspects of movement disorders

 

Austin J. Sumner Physiology and pathophysiology of demyelination of peripheral and central nervous system

 

Carmela L. Tardo Epilepsy and other convulsive disorders of childhood

 

Ann Tilton Spasticity management and neurorehabilitation (including head injury and spinal cord injury) in childhood