Bokkyoo Jun for web

 Bok Kyoo Jun, PhD
 Instructor-Research
 Neuroscience, Cell Biology and Anatomy

 

 LSUHSC Neuroscience
 Center of Excellence
 Floor 8, Room 815
 2020 Gravier Street, Suite D
 New Orleans, LA 70112

 Phone: (504) 599-1521
 Fax: (504) 599-0891

 

Research interests/plan

I am interested in precisely defining and characterizing the lipids that comprise the brain and retina. We know that at the onset of brain disease and retinal degeneration the component lipids begin undergoing changes, where some disappear, some are reduced, some increase, and some appear for the first time.

My research is centered around mass spectrometry. I extract the lipids of interest and analyze them by conventional mass spectrometry or by MALDI (imaging) mass spectrometry. I have access to two colonies of mice that have been genetically altered so that they now have characteristics of two blinding eye diseases, Age-related macular degeneration (AMD) and retinitis pigmentosa (RP). 

My long-term research plan is to isolate retinas and the underlying retinal pigment epithelium from these mice, as well as those of normal mice, and create lipid profiles of these tissues at the onset of the disease, as well as at various times following disease progression. Regulation of these changes must involve enzymatic activity, so I would like to follow these changes in parallel studies where I define changes in proteins (enzymes). This will require me to initiate mass spectrometric techniques for proteomics, as well as my current work with lipidomics. 

Once characterization has progressed, I wish to compare my results with changes in human degenerative diseases. I can have access to human donor eyes from NIH-sponsored eye banks in which some samples will be normal tissues, while others will be tissues expressing retinal degeneration.  

I hope to define initial causes of these diseases, moving from a mouse study to human analysis, where my results can suggest possible means of intervention to prevent, slow, or halt these pathological conditions. 

Education

2001 - Ph.D. in Physics,
Department of Physics and Astronomy
Tufts University, Medford, MA, USA

1991 - MS. in Astrophysics,
Department of Astronomy,
Seoul National University, Seoul, Korea  

1988 - BS. in Astrophysics ,
Department of Astronomy,
Seoul National University, Seoul, Korea  

Work Experience

2010 - 2016
LSU Health Sciences Center, Neuroscience Center of Excellence, New Orleans, LA
Post-Doctoral Researcher

2006 - 2010
LSU Health Sciences Center, Biochemistry, New Orleans, LA|
Post-Doctoral Researcher

2001 - 2005
Bruker Optics Inc., Billerica, MA
Applications Scientist

Publications

Jun, Bokkyoo, Mukherjee, Pranab K., Asatryan Aram, Kautzmann, Marie-Audrey, Heap, Jessica, Gordon, William C., Bhattacharjee, Surjyadipta, Yang, Rong, Petasis, Nicos A., Bazan, Nicolas G. Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity, Scientific Reports, 7:5279, 2017

Zhu J., Chaki M., Lu D., Ren C., Wang S.S., Rauhauser A.A., Li B., Zimmerman S., Jun B., Du Y., Vadnagara K., Wang H., Elhadi S., Quigg R.J., Topham M.K., Mohan C., Ozaltin F., Zhou X.J., Marciano D.K., Bazan N.G., Attanasio M. [2016],
Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production
Am J Physiol Renal Physiol. 2016 Feb 17:ajprenal.00431.2015. doi: 10.1152/ajprenal.00431.2015.

Rice D.S., Calandria J.M., Gordon W.C,. Jun B., Zhou Y., Gelfman C.M., Li S., Jin M., Knott E.J., Chang B., Abuin A., El-Samman T.I., Potter D., Platt K.A., Bazan N.G. [2015],
Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival
Nature Communications 6:6628 DOI;10.1038/ncomms7228

Calandria J.M., Asatryan A., Balaszczuk V., Knott E.J., Jun B.K., Mukherjee P.K., Belayev L., Bazan N.G. [2015],
NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. 
Cell Death Differ.  doi: 10.1038/cdd.2014.233

Sheets K.G., Jun B., Zhou Y., Zhu M., Petasis N.A., Gordon W.C. and Bazan N.G. [2013],
Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1,
Molecular Vision, 19, 1747-1759

Bazan N.G., Eady T., Khoutorova L., Atkins K., Hong S., Lu Y., Zhang C, Jun B., Obenaus A., Fredman G., Zhu M., Winkler J., Petasis A.,  Serhan C. and Belayev L. [2012],
Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke,
Experimental Neurology, 236, 122–130

Jun B. and Kim S. [2010],
Real-Time structural transitions are coupled to chemical steps in ATP hydrolysis by Eg5 kinesin,
Journal of Biological Chemistry, 285, 11073

Ding X., Fries D. and Jun B. [2006],
A Study of Hydrogel Thermal-Dynamics Using Fourier Transform Infrared
Polymer , 47,  4718-4725 

Kamberi M., Kim Y., Jun B. and Riley C.M. [2005],
The Effects of Sucrose on Stability of Human Brain Natriuretic peptide [hBNP(1-32)] and Synthetic Human Parathyroid Hormone [hPTH(1-34)]
Journal of Peptide Research, 66, 348-356

Bothner B., Taylor D., Jun B., Lee K.K., Siuzdak G., Schultz C.P. and Johnson J.E. [2005],
Maturation of a Tetravirus Capsid alters the Dynamic Properties and creates a Metastable Complex,
Virology, 334, 17-27.

Lee A.S., Galea C., DiGiammarino E.L., Jun B., Murti G., Ribeiro R.C., Zambetti G., Schultz C.P. and Kriwacki R.W. [2003],
Reversible Amyloid Formation by the p53 Tetramerization Domain and a Cancer-associated Mutant,
J. Mol. Biol., 327, 699-709.