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lentz_jennifer

Jennifer Lentz, Ph.D.

Research Assistant Professor
Department of Otorhinolaryngology and Biocommunications
and member of the Neuroscience Center of Excellence, LSUHSC

Mailing Address:

Neuroscience Center
LSUHSC 2020 Gravier Street, 8th Floor
New Orleans, LA 70112

Email: JLentz@lsuhsc.edu

Lab: (504) 599-0400
Office: (504) 599-0891

Degrees

BA, Biology and Chemistry, May 1992, Monmouth College, Monmouth, Illinois
PhD, Genetics, May, 2007, Louisiana State University Health Sciences Center, Louisiana

 

Bio

1992-1993 Technician, Abbott Laboratories, Abbott Park, IL
1993-1995 Research Technician, Mosier Lab, The Scripps Research Institute, San Diego, CA
1996-1997 Technician, Quidel Corporation, San Diego, CA
1997-2001 Research and Development Chemist, Prometheus Laboratories, Inc., San Diego, CA
2001-2002 Research Associate III, Elizabeth Mannick MD, Department of Pediatrics, LSUHSC
2002-2007 Research Associate III and PhD Student, Bronya Keats PhD (mentor), Department of Genetics, LSUHSC
2007-2008 Postdoctoral Researcher, Bronya Keats PhD (mentor), Department of Genetics, LSUHSC
2008-2011 Postdoctoral Researcher, Nicolas Bazan MD,PhD (mentor), Neuroscience Center, LSUHSC
2012-present Research Assistant Professor, Department of Otorhinolaryngology and Biocommunications and member of the Neuroscience Center of Excellence, LSUHSC

 

In The News

Rescue from Hearing Loss in Usher's Syndrome
Karen B. Avraham, Ph.D.
N Engl J Med 2013; 369:1758-1760 October 31, 2013 DOI: 10.1056/NEJMcibr1311048

lentz_and_the_mouse

Dr. Hamilton Farris, Mette Flatt, Dr. William Gordon,
Dr. Jennifer Lentz and the mouse and Dr. Nicolas Bazan (the research team)
Local medical research team makes breakthrough in curing deafness
Meg Farris, WWWLTV.com, February, 4 2013.
link to page

Genetic Patch 'stops deafness' in newborn mice. J. Gallagher, BBC News Health, February 4, 2013.

Researchers Develop Rx for Deafness, Impaired Balance in Mouse Model of Usher syndrome. Provided by LSUHSC to Science Daily via EurekaAlert!, February 4, 2013.

Scientists Prevent Development of Deafness in Animals Engineered to have Usher Syndrome. Provided by RFUMC to Science Daily via EurekaAlert!, February 4, 2013.

Researchers Devolop Rx fro Deafness, Impaired Balance in Mouse Model of Usher Syndrome. Provided by LSUHSC, Science Newsline Medicine & Health Care. February 4, 2013.

Gene Therapy in mice gives hope to the deaf. A France-Presse, The Raw Story, February 4, 2013.

Partial fix for Usher syndrome found in mice. The Associated Press, USA Today, February, 9, 2013.

Molecular therapy: Deafness Diverted. Nature Publishing Group, February 13, 2013.

LSU Health Sciences Center Discovers Breakthrough Therapy to Cure Deafness. J Ballard, Silicon Bayou News, February 19, 2013

Research Interests

Jennifer J. Lentz Laboratory for Usher syndrome Research

The overall goal of my research is to develop a therapeutic approach to prevent or cure the deafness and blindness associated with Usher syndrome (Usher), the most common genetic cause of combined deafness and blindness.  Currently, there are 3 clinical sub-types of Usher syndrome based on the severity and age of onset of deafness and blindness, and in some patients, the presence of vestibular areflexia (balance disorder).  Genetically, there are 12 known genes associated with Usher syndrome; 6 for Usher type 1, 3 for Usher type 2, and 2 for Usher type 3.  At LSUHSC-NO we focus on Usher syndrome type 1C, which affects the Acadian populations of south Louisiana and Canada.  Approximately 6-8% of type 1 Usher cases are caused by mutations in the USH1C gene, which encodes the protein harmonin. The USH1C.216G>A (216A) mutation accounts for all cases of Usher 1 in Acadian populations.  This mutation creates a cryptic splice site that is used preferentially over the authentic splice site of exon 3, which results in a frameshift that creates a stop codon in exon 4, thus producing a  truncated harmonin protein.  My laboratory created a model of USH1C by knocking-in the 216A mutation responsible for the combined deafness, blindness and vestibular dysfunction in an Acadian patient of south Louisiana.  The Usher mutant mice also have profound congenital deafness, vestibular dysfunction and retinal degeneration characteristic of human Usher.  My laboratory uses this Usher mouse model to understand the underlying mechanisms that lead to the dual sensory loss associated with Usher syndrome, and to develop therapies aimed at preventing or curing deafness and blindness.

Selected Publications

H.R. Rosen, J.J. Lentz, S.L. Rose, J. Rabkin, C.L. Corless, K. Taylor and L. Chou. “Donor Polymorphism of Tumor Necrosis Factor Gene: Relationship with Variable Severity of Hepatitis C Recurrence Following Liver Transplantation.” Transplantation, December, 1999, 68(12):1898-902.

Rosen HR, McHutchison JG, Conrad AJ, Lentz JJ, Marousek G, Rose SL, Zaman A, Taylor K, Chou S. Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C. American Journal of Gastroenterology, March, 2002, 97(3): 714-20.

Mannick EE, Schurr JR, Zapata A, Lentz JJ, Gastanaduy M, Cote RL, Delgado A, Correa P, Correa H. Gene expression in gastric biopsies from patients infected with Helicobacter pylori. Scand J Gastroenterol. 2004 Dec;39(12):1192-200.

Mannick EE, Bonomolo JC, Horswell R, Lentz JJ, Serrano MS, Zapata-Velandia A, Gastanaduy M, Himel JL, Rose SL, Udall JN Jr, Hornick CA, Liu Z. Gene expression in mononuclear cells from patients with inflammatory bowel disease. Clin Immunol. 2004 Sep;112(3):247-57.


Lentz J, Jodelka FM, Hinrick AJ, McCaffrey KE, Farris HE, Spalitta MJ, Bazan NG, Duelli DM, Rigo F, Hastings ML; Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness; Nature Medicine Advance Published Online February 2013 1-8.

Additional Info

Membership in Professional Organizations

The Association for Research in Otolaryngology
The Association for Research in Vision and Ophthalmology
Society for Neuroscience
Association for Women in Science


Current Funding:

LSU Dean's Office, ENT and Neuroscience Center 2/2012 - 2/2015
P30 GM103340 (PI: Bazan)
NIH/NIGMS 11/12/2012 - 5/30/2013 $50,000 Direct
Role: Pilot Project PI
Title: Antisense Oligonucleotides as a novel therapeutic for Usher syndrome

1R01DC012596-01A1 (PI: Hastings)
NIH/NIDCD 2/02/2013-2/02-2017 $249,900/year Total Direct
Role: Co-Investigator
Title: Correction of Hearing and Vestibular defects in a Mouse Model for Deafness

FFB Early Translational Research Award Program FY13 (PI: Lentz)
Foundation Fighting Blindness 4/2013 - 4/2016 $300,000/year Total Direct
Role: PI
Title: An Antisense-Oligonucleotide Treatment for Retinitis Pigmentosa in Usher syndrome