Ludmila Belayev, M.D.
Professor/Research Neurosurgery, Neurology and Neuroscience
2020 Gravier Street
Suite 9B4, Room 946A
New Orleans, LA 70112
Phone: (504) 599-0849
Fax: (504) 599-0488
Medical University School, Novosibirsk, Russia, Neurosurgery, 1978-1982.
Medical University School, Novosibirsk, Russia, Surgery, 1977-1978.
Medical University School, Novosibirsk, Russia, M.D., 1970-1976.
Post-Doctoral Fellowships: Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, 1994-1996.
2013 to present: Professor of Neurology, School of Medicine, LSUHSC
2012 to present: Professor of Neurosurgery and Neuroscience, School of Medicine, LSUHSC
2006 to 2012: Research Associate Professor of Neurosurgery and Neuroscience, School of Medicine, LSUHSC
2005 to 2006: Director of Commercial Research and Pharmacology, Inotek Pharmaceuticals Corporation
2003-2005: Research Associate Professor, Department of Neurology, University of Miami School of Medicine
1998-2003: Research Assistant Professor, Department of Neurology, University of Miami School of Medicine
1994-1998: Postdoctoral Research Associate, Department of Neurology, University of Miami School of Medicine
1992-1994: Neuroscientist, Department of Pharmacology, Pharmos Corp., Rehovot, Israel
1979-1990: Neurosurgeon, Department of Neurosurgery, Novosibirsk Regional Hospital, Russia
1989: Neurovascular Fellowship-Institute of Neurosurgery N.N. Burdenko, Moscow, Russia
1991: Course of Internal Medicine, Ishilov Hospital, Tel-Aviv, Israel
CURRENT RESEARCH PROJECTS
Neuroprotection study with LAU-0901 in focal cerebral ischemia.
DHA and DHA-Albumin studies in the experimental stroke models.
Development and evaluations of Fluid Percussion Injury model in rats.
I. Development and evaluation of animal models of stroke:
Models of global cerebral ischemia in rats and mice:
a) Two-vessel occlusion model of forebrain ischemia
b) Four-vessel occlusion model of forebrain ischemia
Models of focal cerebral ischemia in rats and mice:
a) Middle cerebral artery occlusion by intraluminal suture
b) Mechanical (electrocoagulation, microclip)
Hemorrhagic models in rats and mice:
a) Intracerebral hemorrhagic models (blood, collagenase)
b) SAH and vasospasm: (injection of blood into cisterna magna and puncture of cerebral artery)
II. Development and evaluation of animal models of traumatic brain injury:
a) Lateral fluid percussion injury model
b) Controlled weight drop brain injury
III. Recovering function after brain injury (neural plasticity and reorganization), expertise in different neurobehavioral tests.
IV. Evaluation of blood-brain integrity.
V. Histopathology and image analysis of the brain after stroke and head trauma.
in brain ischemia and traumatic brain injury.
Non-clinical animal pharmacology, pharmacokinetics and toxicology studies.
|Committees & Administrative Responsibilities
Committees & Administrative Responsibilities
Peer Review Study committees:
Reviewer, NIH, BINP study section, Washington, DC, 2011 - to current
Reviewer, NIH, Brain Disorders and Clinical Neurosciences, ZRG1 BDCN-Y-02 Special Emphasis Panel, - 2010.
Reviewer, Department of Veterans Affairs, Regenerative Medicine and Spinal Cord Injury panel, Washington, DC, - 2010.
Member, American Heart Association, Brain– Basic-Peer Review Study Group, 2010- to current
Member, American Heart Association, Region 4 Brain 2-Peer Review Study Group, 2009
Experimental & Translational Stroke Medicine (2012 – to current)
ISRN Neurology (2010- to current)
The Science Advisory Board (2010- to current)
BMC Neurology (2003–to current)
L. Belayev. Overcoming barriers to translation from experimental stroke models. In: Lapchak and Zhang (Eds),
Stroke targets to clinical trials, Springer, Chapter 24, 471-492, 2012.
L. Belayev, Y. Lu, NG Bazan. Brain ischemia and reperfusion: cellular and molecular mechanisms in stroke injury.
In: Brady, Albers, Price, Siegel (Eds), Basic Neurochemistry, Elsevier, Chapter 35, 621-642, 2012.
L. Belayev, M. Endres and V. Prinz. Focal cerebral ischemia in the mouse and rat using the intraluminal suture-filament model.
In: U. Dirnagl, (Ed), Rodent Models of Stroke, The Springer, Chapter 4, 29-40, 2010.
L. Belayev. Mouse Intracerebral Hemorrhage Model. In: Jun Chen, Zao Xu, Xiao-Ming Xu, and John Zhang, (Eds),
Animal Models of Acute Neurological Injuries, The Humana Press Inc, 349-357, 2009.
- Eady TN, Belayev L, Khoutorova L, Atkins KD, Zhang C, Bazan NG.
Docosahexaenoic Acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats.
PLoS One, 7:e46151, 2012.
- Bazan NG, Eady TN, Khoutorova L, Atkins KD, Hong S, Lu Y, Zhang C, Jun B, Obenaus A, Fredman G, Zhu M, Winkler JW, Petasis NA, Serhan CN, Belayev L.Novel aspirin-triggered Neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke.
Exp Neurol, 236:122-130, 2012.
- Eady TN, Khoutorova L, Atkins KD, Bazan NG, Belayev L.
Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window.
Exp Transl Stroke Med, 4:19, 2012.
Belayev L, Eady TN, Khoutorova L, Atkins K, Obenaus A, Cordoba M, Vaquero JJ, Builla JA, Bazan NG.
Superior Neuroprotective Efficacy of LAU-0901, a novel Platelet Activating Factor Antagonist, in Experimental Stroke.
Translational Stroke Research, 3:154-163, 2012.
Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA.
Novel Proresolving Aspirin-Triggered DHA Pathway.
Cell:Chem Biol. 18:976-987, 2011.
Belayev L, Khoutorova L, Atkins K, Eady TN, Hong S, Lu Y, Obenaus A, Bazan NG.
Docosahexaenoic acid therapy of experimental ischemic stroke.
Translational Stroke Research, 2:33-41, 2011.
Belayev L, Khoutorova L, Atkins K, Bazan NG.
Robust Docosahexaenoic Acid-Mediated Neuroprotection in a Rat Model of Transient Focal Cerebral Ischemia.
Stroke, 40, 3121-3126, 2009.
Belayev L, Khoutorova L, Zhao KL, Davidoff AW, Moore AF, Cramer SC.
A novel therapeutic strategy for experimental stroke.
Brain Research, 1280:117-123, 2009.
Belayev L, Khoutorova L, Atkins K, Cherqui A, Alvarez-Builla J, Bazan NG.
LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat.
Brain Res, 1253:184-190, 2009.
Belayev L, Khoutorova L, Atkins K, Gordon WC, Bazan NG.
LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia.
Exp. Neurol, 214:253-258, 2008.
, Obenaus A, Zhao W, Saul I, Busto R, Wu C, Vigdorchik A, Lin B, Ginsberg MD.
Experimental intracerebral hematoma in the rat: characterization by sequential magnetic resonance imaging, behavior, and histopathology.
Effect of albumin therapy.
Brain Res, 1157:146-155, 2007.
- Ley JJ, Belayev L, Saul I, Becker DA, Ginsberg MD.
Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose–response and therapeutic window,
Brain Res, 1180:101-110, 2007.
Belayev L, VL Marcheselli, L. Khoutorova, EB. Rodriguez de Turco, R. Busto, MD Ginsberg, NG Bazan.
Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection.
Stroke, 36:118-123, 2005.