Chu Chen, Ph.D.
Professor of Otorhinolaryngology and Neuroscience
2020 Gravier Street, Suite D
New Orleans, LA 70112
Phone: (504) 599-0918
Fax: (504) 599-0488
http://www.medschool.lsuhsc.edu/faculty/docs/CChen 21st NSR.pdf
1994-1996 Postdoctoral fellow, LSU Health Sciences Center, New Orleans
1989-1993 PhD, Tulane University, New Orleans
1983-1986 MS, Zhejiang Medical University, Hangzhou, China
1979-1983 BS, Nanjing University, Nanjing, China
7/2013 – present
Professor with tenure, Neuroscience Center and Department of Otorhinolaryngology, LSU Health Sciences Center in New Orleans
8/2012 - present
VA’s biomedical laboratory and clinical science research and development non-clinician intramural program member
7/2008 - 6/2013
Associate Professor with tenure, Neuroscience Center and Department of Otorhinolaryngology, LSU Health Sciences Center in New Orleans
Tenure track Assistant Professor, Department of Otorhinolaryngology and Neuroscience Center of Excellence, LSUHSC
Research Assistant Professor, Department of Otorhinolaryngology and Neuroscience Center of Excellence, LSUHSC
Research Assistant Professor, Department of Otorhinolaryngology, LSUHSC
Lecturer, Department of Physiology, Zhejiang Medical University, Hangzhou, China
Instructor, Department of Physiology, Zhejiang Medical University, Hangzhou, China
Neuromodulation of ion channels;
Neuroinflammation in hippocampal synaptic transmission and plasticity;
Mechanisms of neurodegenerative diseases
(e.g., Alzheimer’s disease, chronic traumatic encephalopathy);
COX-2 oxidative metabolism of endogenous cannabinoids in
synaptic activity and neuronal survival;
Mechanisms of marijuana-altered synaptic and cognitive function,
and cannabinoid tolerance.
Inflammation is now believed to be a common mechanism of disease. Neuroinflammation, the inflammatory response that occurs in the nervous system, has been implicated in many brain disorders such as epilepsy, traumatic brain injury and stroke, and in neurodegenerative diseases such as multiple sclerosis, Parkinson’s and Alzheimer’s diseases. However, our understanding of the molecular mechanisms underlying neuroinflammation in the pathogeneses of neurodegenerative diseases is still elusive. My research programs focus on neuroinflammation in synaptic plasticity and neurodegenerative diseases. Specifically, I am interested in endocannabinoid and prostaglandin signaling in hippocampal synaptic plasticity and pathogenesis of Alzheimer’s disease. Recent evidence shows that a large proportion of prostaglandins derives from hydrolysis of the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) by the enzyme monoacylglycerol lipase (MAGL), that primarily metabolizes 2-AG in the brain. While 2-AG exhibits anti-inflammatory and neuroprotective properties, prostaglandins (e.g., PGE2) are proinflammatory and neurotoxic. Therefore, MAGL plays an important role in regulation of endocannabinoid 2-AG and prostaglandin signaling (See inset). Thus, inhibition of MAGL will result in strengthening anti-inflammatory and neuroprotective 2-AG signaling, while reducing proinflammatory arachidonic acid and eicosanoid levels. We are currently addressing this important issue as to whether inactivation of MAGL is able to alter hippocampal synaptic signaling and reduce neuropathology of Alzheimer’s disease and whether epigenetic mechanisms such as noncoding microRNAs are involved in regulation of synaptic plasticity and neuropathology by endocannabinoid and prostaglandin signaling.
2002-present Lecture: Investigative Neuroscience 203 to PhD graduate program students
2002-present Lecture: Molecular Neurobiology 250 to PhD graduate program students
- Zhang J., Hu M., Teng Z., Tang Y. & Chen C. (2014) Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer’s disease. Journal of Neuroscience (In press). DOI:10.1523/JNEUROSCI.1165-14.2014
- Xu J. & Chen C. (2014) Endocannabinoids in synaptic plasticity and neuroprotection. Neuroscientist (In press) DOI: 10.1177/1073858414524632
- Chen R., Zhang J., Fan N., Teng Z., Wu Y., Yang H., Tang Y., Sun H., Song Y. & Chen C. (2013) Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell 155:1154-1165.
(Featured and highlighted in Cell:http://www.elsevier.com/connect/preventing-marijuana-induced-memory-problems-with-OTC-painkillers;Science: http://news.sciencemag.org/brain-behavior/2013/11/painkillers-may-curb-memory-loss-medical-marijuana; Science Signaling: Snuffing Out Marijuana Inflammation. 6(304):ec291,2013: http://stke.sciencemag.org/cgi/content/abstract/6/304/ec291; Nature: Painkiller kills the bad effects of pot. 503(7477):440,2013: http://www.nature.com/nature/journal/v503/n7477/full/503440b.html; Nature Reviews Neuroscience: Memory: a boost for medical marijuana? 15(1): 2-3,2014: http://www.nature.com/nrn/journal/v15/n1/full/nrn3659.html; and covered by various news media)
- Chen R., Zhang J., Wu Y., Wang D., Feng G., Tang Y.P., Teng Z. & Chen C. (2012) Monoacylglycerol lipase is a therapeutic target for Alzheimer’s disease. Cell Reports 2:1329-1339 (Covered by various news media).
He H., Mahnke A., Doyle S., Fan N., Wang C., Hall B., Tang Y.P., Inglis F., Chen C. & Erickson J.D. (2012) A neurodevelopmental role for VGLUT2 in pyramidal neuron maturation and spatial learning. Journal of Neuroscience 32:15886-15901
Pan W., Hsuchou H., Jayaram B., Khan R.S., Huang E.Y., Wu X., Chen C. & Kastin A.J. (2012) Leptin action on nonneuronal cells in the CNS: potential clinical applications. Annals of the New York Academy of Sciences 1264:64-71.
- Xu J., Zhang J. & Chen C., (2012) Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids. Journal of Physiology (Lond) 590:2305-2315.
- Du H., Chen X., Zhang J. & Chen C. (2011) Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated by PPAR-gamma. British Journal of Pharmacology (2011) 163:1533-1549.
- Chen X., Zhang J. & Chen C. (2011) Endocannabinoid 2-arachidonoylglycerol protects neurons against beta-amyloid insults. Neuroscience 178:159-168.
- Yu T., Li Z., Jia Z., Clapcote S.J., Liu C., Li S., Asrar S., Pao A., Chen R., Fan N., Carattini-Rivera S., Bechard A.R., Spring S., Henkelman R.M., Stoica G., Matsui S-I., Nowak N.J., Roder J.C., Chen C., Bradley A. & Yu Y.E. (2010) A mouse model of Down Syndrome trisomic for all human chromosome 21 syntenic regions. Human Molecular Genetics 19:2780–2791.
Chen C. (2010) COX-2’s new role in inflammation. Nature Chemical Biology 6: 401-402.
- Xu J., Zhang J. & Chen C. (2010) Endocannabinoids differentially modulate long-term depression in rat hippocampal CA1 pyramidal neurons. PLoS ONE 5:e10306.
- Sang N., Zhang J. & Chen C. (2010) Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. Neurochemistry International 56:590-596.
- Fan N., Yang H., Zhang J. & Chen C. (2010) Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for Δ9-THC-impaired hippocampal synaptic plasticity. Journal of Neurochemistry 112:691-702.
- Grewal S., Defamie N., Zhang X., Gois S.D., Shawki A., Mackenzie B., Chen C., Varoqui H. & Erickson J.D. (2009) SNAT2 amino-acid transporter is regulated by osmolytes of the SLC6 GABA transporter subfamily and may play no role in delivering glutamine for spontaneous glutamatergic transmission. Journal of Biological Chemistry 284:11224-11236.
- Yang H., Zhang J., Breyer R.M. & Chen C. (2009) Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor. Journal of Neurochemistry 108: 295-304.
- Zhang J. & Chen C. (2008) Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. Journal of Biological Chemistry 283: 22601–22611.
- Yang H. & Chen C. (2008) COX-2 in synaptic signaling. Current Pharmaceutical Design 14: 1443-1451.
- Yang H., Zhang J., Andreasson K. & Chen C. (2008)COX-2 Oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticity. Molecular and Cellular Neuroscience 37: 682-695.
- Sang N., Zhang J. & Chen C. (2007) COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. Journal of Neurochemistry 102: 1966-1977.
- Sang N. & Chen C. (2006) Lipid signaling and synaptic plasticity. Neuroscientist 12: 425-434.
- Sang N., Zhang J. & Chen C. (2006) PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons. Journal of Physiology (Lond) 572: 735-745.
- Sang N., Zhang J., Marcheselli V., Bazan, N.G. & Chen C. (2005) Postsynaptically synthesized prostaglandin E2 modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor. Journal of Neuroscience 25: 9858-9870.
- Gois S.D., Schafer MK-H., Defamie N., Chen C, Ricci A, Weihe E, Varoqui H & Erickson JD. (2005) Homeostatic scaling of vesicular glutamate and GABA transporters expression in rat neocortical circuits. Journal of Neuroscience 25:7121-7133.
- Zhu P., Genc A., Zhang X., Zhang J., Bazan N.G. & Chen C. (2005) Heterogeneous expression and regulation of PGE2 receptors in the hippocampus. Journal of Neuroscience Research 81: 817-826.
Chen C. & Bazan N.G. (2005) Endogenous PGE2 regulates membrane excitability and synaptic transmission in rat hippocampal CA1 pyramidal neurons. Journal of Neurophysiology 93: 929-941.
Chen C. (2004) ZD7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cells synapses. European Journal of Neuroscience 19: 643-649.
- McDermott C.M., LaHoste G.L., Chen C., Musto A., Bazan N.G. & Magee J.C. (2003) Sleep deprivation causes behavioral, synaptic and membrane excitability alterations in hippocampal neurons. Journal of Neuroscience 23: 9687-9695.
Chen C., Magee J.C. & Bazan N.G., (2002) Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity. Journal of Neurophysiology 87:2851-2857.
- Rodriguez de Turco E.B.R., Tang W., Topham M.K., Sakane F., Marcheselli V.L., Chen C., Taketomi A., Prescott S. & Bazan N.G. (2001) Diacylglcerol kinase epsilon regulates suizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. Proceedings of National Academy of Science USA 98: 4740-4745.
Chen C., Magee J.C., Marcheselli V., Hardy M. & Bazan N.G. (2001) Attenuated long-term potentiation in hippocampal dentate gyrus neurons of mice deficient in the PAF receptor. Journal of Neurophysiology 85: 384-390.
Source: NIH-NINDS R01NS076815 6/15/2012-3/31/2017
Title: Endocannabinoids in neurodegenerative diseases.
Role on Grant: PI.
Source: NIH-NIA R21AG039669 4/1/2011-3/31/2013
Title: MAGL inhibition in prevention and treatment of Alzheimer’s disease.
Role on Grant: PI.
Source: NIH-NINDS R01NS054886 6/1/2007-11/30/2012
Title: Endocannabinoids in COX-2 mediated synaptic modification and neurotoxicity.
Role on Grant: PI.