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2009 2:01:18 PM

Sonia Gasparini, Ph.D.

Associate Professor of Neuroscience, Cell Biology and Anatomy

Neuroscience Center of Excellence
2020 Gravier Street, New Orleans, LA 70112

(504) 599-0869

sgaspa1@lsuhsc.edu

http://www.medschool.lsuhsc.edu/faculty/docs/Gasparini.pdf

Bio

Degrees

1994-1998:  PhD, University of Milano, Italy

1989-1994:  BSc, University of Milano, Italy

Positions

2014 -  present: Associate Professor of Cell Biology and Anatomy and Neuroscience, Neuroscience Center of Excellence, LSUHSC

2010-2014:  Assistant Professor of Cell Biology and Anatomy and Neuroscience, Neuroscience Center of Excellence, LSUHSC

2005-2010:  Research Assistant Professor, Neuroscience Center of Excellence, LSUHSC

2001-2004: Postdoctoral fellow, Neuroscience Center of Excellence, LSUHSC, New Orleans, LA

1998-2000:  Postdoctoral fellow, Biophysics Sector, SISSA-ISAS, Trieste Italy

Awards/Recognitions/Lectures

2015: Jack Hines III Memorial Award for Outstanding Service to the LSUHSC School of Graduate Studies

2015:  LSU School of Medicine Faculty Assembly Outstanding
Service to the Community award

2011:  LSU School of Medicine Alumni Excellence Award

2009:  Invited speaker at the Gordon Research Conference
“Dendrites: Molecules, Structure and Function”, Il Ciocco, Italy

2008:  Dart Neuroscience Scholars Program in Learning
and Memory Award (PI)

2007:  Albert and Ellen Grass Faculty Program Award (PI)

2005:  Albert and Ellen Grass Faculty Program Award (PI)

2002-2004:  NARSAD Young Investigator Award

2002:  Ochsner Clinic Foundation Research Award

2000:  SINS (Italian Society for Neuroscience) Travel Fellowship

1997: Federation of Biochemical Societies Youth Travel Fund

Research Interests

Research Interests and Goals:
Information processing and memory formation. Dendritic excitability and plasticity: synaptic transmission and voltage-dependent channel activity in hippocampal and entorhinal neurons

Research Interest Statement:

Dendritic integration in the entorhinal cortex (EC)
The enthorhinal cortex is a key relay structure for the flow of information between the hippocampus and the neocortex. Not only does it act as a primary interface, it also plays a critical role in the computation of multi-sensory and cognitive modalities. The latter function is clearly supported by the direct involvement of the entorhinal cortex in neurodegenerative and psychiatric disorders such as Alzheimer’s disease, epilepsy and schizophrenia. In particular, layer V neurons, being the main target of processed outputs leaving the hippocampal formation and sending their axons to cortical regions, play an important role in the consolidation and replay of memories, which involve hippocampal-neocortical communications.

To understand the function of EC layer V neurons, it is essential to understand how they integrate the inputs they receive to generate the output that is transferred to the neocortex; this complex process depends on the neuronal morphology and the density and properties of dendritic voltage-dependent channels. Despite their fundamental role in the consolidation and replay of memories, very little is known about the integrative features of these neurons.

By elucidating the mechanisms of dendritic integration in the entorhinal cortex, these studies will increase our knowledge of memory processing. Relating pathological effects to electrophysiological properties of neuronal compartments that have not been fully explored, such as dendrites, may shed light on basic neuronal properties and provide insights for novel points of therapeutic intervention and disease prevention.

Current research projects:
 In our research, we employ electro-physiological techniques (dendritic and somatic patch clamp recordings) coupled with electrical stimulation and multi-photon imaging and uncaging of caged neurotransmitters (such as glutamate) on brain slices. Using these techniques, we are currently studying the properties of the synaptic inputs and how they are integrated with voltage-dependent currents, the initiation of active processes in the dendrites (i.e. dendritic spikes) and their impact on the somatic output in hippocampal CA1 neurons and neurons of the deep layers of the entorhinal cortex. The ultimate goal is to relate the input-output features of these neurons to the different behavioral states and memory formation.


2009 2:20:41 PM

Teaching Activities

2015- present: Co-director of the Cell and Molecular Biology course (INTER 121)

2010- present: Co-director of the Introduction to Research Resources course (INTER 101)

2010- present: Lecturer in the Cell and Molecular Biology course (INTER 121), topic Membrane Properties and Electrical Potential

2008- present: Lecturer in the Synaptic Organization of the Brain course (ANAT 264), topic Hippocampus

2007- present: Lecturer in the Biological Systems B course (INTER 132), topic Passive and Active Properties of Dendrites and Axons

2006- present: Lecturer in the Investigative Neuroscience course (NEURO 203), topic Membrane Potential and Action Potential

2006- present: Lecturer in the Molecular Neurobiology course (NEURO 250), topic Structure and Function of Voltage-Gated Ion Channels

Selected Publications

 Key Recent Papers:

Wang, S., Musharoff, M., Canavier, C. C. & Gasparini, S. (2013). Hippocampal CA1 pyramidal neurons exhibit Type 1 phase response curves and Type 1 excitability. J. Neurophysiol. 109:2757-2766

Medinilla, V., Johnson, O. & Gasparini, S. (2013). Features of proximal and distal excitatory synaptic inputs to layer V neurons of the rat medial entorhinal cortex. J Physiol. 591:169-183

Gasparini, S. (2011). Distance- and activity-dependent modulation of spike back-propagation in layer V pyramidal neurons of the medial entorhinal cortex. J. Neurophysiol. 105: 1372-1379

Ascoli, G.*, Gasparini, S.*, Medinilla, V. & Migliore, M. (2010). Local control of post-inhibitory rebound spiking in CA1 pyramidal neuron dendrites. J. Neurosci. 30:6434-6442.*These authors contributed equally

Gasparini, S., Losonczy, A., Chen, X., Johnston, D. & Magee J. C. (2007). Associative pairing enhances action potential back-propagation in radial oblique branches of CA1 pyramidal neurons. J Physiol. 580:787-800

Gasparini S. & Magee, J. C. (2006). State-dependent dendritic computation in hippocampal CA1 pyramidal neurons. J. Neurosci. 26:2088-2100

Gasparini, S., Migliore, M. & Magee, J. C. (2004). On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. J. Neurosci. 24: 11046-11056

 

 Book Chapters:

Gasparini S. & Migliore M (2015). Action Potential Back-Propagation. In: Encyclopedia of Computational Neuroscience, pp 133-137, edited by D. Jaeger and R. Jung. Springer New York. DOI: 10.1007/SpringerReference_348188

Gasparini, S. & Palmer, L. M. (2016). Dendritic patching and imaging in hippocampal and cortical slices. In: Advanced Patch Clamp Analysis for Neuroscientists, Neuromethods Vol. 113, pp. 97-122, edited by A. Korngreen. Springer New York.

Additional Info

Funding:

“Dendritic Integration in the Entorhinal Cortex”
Principal Investigator: Sonia Gasparini, PhD
Agency: NINDS/NIH (R01NS69714). Period: 4/1/2010-03/31/2016