William C. Gordon, Ph.D.
EENT Professor of Neuroscience and Ophthalmology
Center of Excellence
Floor 6, Room 608
2020 Gravier Street, Suite D
New Orleans, LA 70112
Phone: (504) 599-0881
Fax: (504) 599-0891
http://www.medschool.lsuhsc.edu/faculty/docs/Neuroscience Retreat Brochure - Gordon - CV 090210 (2).pdf
1977-1980: Postdoc (Ophthalmology); Baylor College of Medicine, Houston, TX
1970-1977: Ph.D. (Biology); University of South Florida, Tampa, FL
1968-1970: M.Sc. (Biology) (all but thesis); SUNY, Fredonia
1966-1968: B.Sc. (Biology); SUNY, Fredonia, NY
1964-1967: A.Sc.; Jamestown Comm College, Jamestown, NY
2006: Distinguished Alumnus Award; Jamestown Community College, Jamestown, NY
1987: Nominated Teacher of the Year; University of Kansas, Lawrence, KS
1977-1980: NRSA Postdoctoral Fellowship; Baylor College of Medicine, (SF Basinger, preceptor)
1967: Inducted into Beta Beta Beta, the Biological Honor Society; SUNY, Fredonia, NY
cell biology of retina and hippocampus under normal and pathological conditions, neuronal cell death and neuroprotection
Retinal morphology, physiology, and biochemistry
Mitochondrial response during photoreceptor stress
Mechanisms of photoreceptor cell death and protection
Information processing for retinal maintenance
Retinal Inflammation and Neovascularizatio in a Murine
Model of Age-related Macular Degeneration
Age-related Macular Degeneration (AMD) is a disease in which photoreceptors in the central region of the human retina begin to degenerate. As the disease slowly progresses, the resulting central blind spots expand, fuse, and eventually lead to clinical blindness. A hallmark of this disease is the compromise of Bruch’s membrane behind the retina and its associated monolayer of retinal pigment epithelial (RPE) cells, which leads to the growth of capillaries (neovascularization) from the choriocapillaris at the back of the eye into the spaces between the RPE and photoreceptors. This spreading disruption triggers photo-receptor cell death. There are at least two components of this disease: inflammation (both initial and chronic) and neovas-cularization. Our working hypothesis is that regulation or inhibition of these processes will attenuate or halt the spread of photoreceptor death across the retina.
We induce choroidal neovascularization (CNV) in the mouse retina by producing a small hole through the RPE and Bruch’s membrane with an ophthalmic laser. Initial inflammatory processes are observed, followed by the invasion of new capillaries into the retina. We follow these events by measuring the amount of blood leakage into the retina at the lesion sites with angiography. After two weeks, the retina/RPE/choroidal complex is collected as a whole mount and immunolocalization performed to delineate new retinal endothelial cells. Image stacks through each lesion site are collected by confocal microscopy, three-dimensional reconstructions are made, and total capillary volumes calculated.
A group of metabolic metabolites, derived from two omega-3 fatty acids, eicospentaenoic acid and docosahexaenoic acid (EPA and DHA), produce a series of compounds, the resolvins, in the presence of specific lipoxygenases. These are anti-inflammatory and anti-neovascular. Our study involves treatment with these compounds throughout the two-week CNV interval, followed by analysis of the new capillary volumes within the retina at each lesion site, and comparisons with untreated controls.
2004 – present: Associate Professor, Research; Ophthalmology and Neuroscience, LSU Health Sciences Center, New Orleans, LA
1994-2004: Assistant Professor, Research; Department of Ophthalmology and Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, LA
1987-1994: Instructor; Department of Ophthalmology and Neuroscience Center of Excellence, LSU Medical Center, New Orleans, LA
1981-1987: Assistant Professor; Department of Physiology & Cell Biology, University of Kansas, Lawrence, KS
1980-1987: Assistant Professor; Department of Entomology, University of Kansas, Lawrence, KS
1977-1980: Postdoctoral Fellow; Department of Ophthalmology, Baylor College of Medicine, Houston, TX
1975-1977: Instructor; Department of Biology, Hillsborough Community College, Tampa, FL
1970-1977: Graduate Research Assistant; Dept of Biology, University of South Florida, Tampa, FL
1968-1970: Graduate Research Assistant; Archbold Biological Station, Lake Placid, FL; Summer 1968, 1969 Smithsonian Tropical Research Institute, Barro Colorado Island, Panama Canal Zone; Summer 1970
1966-1970: Director of Planetarium; State University of New York, Fredonia, NY
Relevant Papers and Chapters:
Rice, D.S. Calandria, J.M., Gordon, W.C., Jun, B.K., Zhou, Y.D., Gelfman, C.M., Li, S.H., Jin, M., Knott, E.J., Chang, B., Abuin, A., Issa El-Samman, T., Potter, D., Platt, K.A., and Bazan, N.G. Adiponectin Receptor 1 Conserves Docosahexaenoic Acid and Promotes Photoreceptor Cell Survival, Nature Communications, 2015 1-14
Kanan, Y., Gordon, W.C., Mukherjee, P.K., Bazan, N.G., Al-Ubaidi, M.R: Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. (2014) Cellular and Molecular Neurobiology.
Zemski-Berry, K.A., Gordon, W.C., Murphy, R.C., Bazan, N.G: Spatial distribution of phospholipids in the human retina by MALDI imaging mass spectrometry. J Lipid Res. Dec 23. [Epub ahead of print]. (2014) J Lipid Res. 55(3):504-515.
Songhua Li, Jungsoo Lee, Yongdong Zhou, William C. Gordon, James M. Hill, Nicolas G. Bazan, Jeffrey H. Miner, and Minghao Jin; Fatty Acid Transport Protein 4 (FATP4) Prevents Light-Induced Degeneration of Cone and Rod Photoreceptors by Inhibiting RPE65 Isomerase; (2013) The Journal of Neuroscience, 3178:33(7):3178 –318933.
Bazan, N.G., Calandria, J.M., Gordon, W.C: Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. (2013) In: The Importance of Immunonutrition: Lipids. Nestlé Nutr Inst Workshop Ser. Makrides M, Ochoa JB, Szajewska H (eds). Nestec Ltd., Vevey/S. Karger AG, Basel. 77:121-131.
Li, S., Lee, J., Zhou, Y., Gordon, W.C., Hill, J., Bazan, N.G., Miner, J., Jin, M: Fatty Acid Transport Protein 4 (FATP4) Prevents Light-Induced Degeneration of Cone and Rod Photoreceptors by Inhibiting RPE65 Isomerase. (2013)J Neurosci. 33:3178-3189.
Li, S., Yang, Z., Hu, J., Gordon, W.C., Bazan, N.G., Haas, A.L., Bok, D., Jin, M: Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). (2013)J Biol Chem. 288:11395-11406.
Sheets, K.G., Jun, B., Zhou, Y., Gordon, W.C., Bazan, N.G: Microglia Ramification and Redistribution Concomitant with Attenuation of Choroidal Neovascularization by Neuroprotectin D1. (2013) Mol Vis. 19:1747-1759.
Gordon, W.C., Bazan, N.G: Mediator Lipidomics in Ophthalmology: Targets for Modulation in Inflammation, Neuroprotection, and Nerve Regeneration. (2013) Cur Eye Res. 38:995-1005.
Sato, K., Li, S., Gordon, W.C., He, J., Liou, G.I., Hill, J.M., Travis, G.H., Bazan, N.G., Jin, M: Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein. (2013) J Neuroscience. 33:17458-17468
Bazan, N.G., Molina, M.F., Gordon, W.C: Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's and other Neurodegenerative Diseases. Annual Review of Nutrition (2011) 31:321-51.
Zhou, Y., Sheets, K.G., Knott, E.J., Regan, C.E. Jr., Tuo, J., Chan, C.C., Gordon, W.C., Bazan, N.G: Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouse. Experimental Eye Research (2011); 93: 636-648
Sheets, K.G., Zhou, Y., Ertel, M.K., Knott, E.J., Regan, C.E. Jr., Elison, J.R., Gordon, W.C., Gjorstrup, P., Bazan, N.G: Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse. (2010) Mol Vis. 16:320-329.
Knott, E.J., Sheets, K.G., Zhou, Y., Gordon, W.C., Bazan, N.G: Spatial correlation of mouse photoreceptor-RPE thickness between SD-OCT and histology. (2010)Exp Eye Res. 92:155-160.
Lentz, J.J., Gordon, W.C., Farris, H.E., MacDonald, G.H., Cunningham, D.E., Robbins, C.A., Tempel, B.L., Bazan, N.G., Rubel, E.W., Oesterle, E.C., Keats, B.J: Deafness and retinal degeneration in a novel USH1C knock-n mouse model. (2010) Dev Neurobiol. 70:253-267.
Belayev, L., Khoutorova, L., Atkins, K., Gordon, W.C., Alvarez-Builla, J., Bazan, N.G: LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. (2008) 214:253-258.
Mukherjee, P.K., Marcheselli, V.L., Vaccari, J.CdR., Gordon, W.C., Jackson, F., Bazan, N.G: Photoreceptor outer segment phagocytosis selectively attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. PNAS, USA. (2007) 104:13158-13163.
Cortina, M. S., Gordon, W. C., Lukiw, W.J., Bazan, N.G: Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Exp Eye Res. (2005) 81:742-750.
Colangelo, V., Gordon, W.C., Mukherjee, P.K., Trivedi, P., Ottino, P: Downregulation of COX-2 and JNK expression after induction of ischemic tolerance in the gerbil brain. Brain Res. (2004) 1016:195-200.
Cortina, M.S., Gordon, W.C , Lukiw, W.J., Bazan N.G: Light-induced photoreceptor damage triggers DNA repair: Differential fate of rods and cones, Retinal Degenerations: Mechanism and Experimental Therapy (LaVail MM, Hollyfield JG, Anderson RE, eds) pp. 229-240. Kluwer Academic/Plenum Publishers: New York, (2003).
Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G: DNA repair in photoreceptor survival. Molecular Neurobiol. (2003) 28:111-122.
Gordon, W.C., Casey D.M., Lukiw, W.J., Bazan, N.G: DNA damage and repair in light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci. (2002) 43:3511-3521.
Lukiw, W.J., Gordon, W.C., Rogaev, E.I., Thompson, H., Bazan, N.G: Presenilin-2 (PS-2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis. Molecular Neuroscience(2001) 12:53-57.
Rodriguez de Turco, E.B., Jackson, F.R., Parkins, N., Gordon, W.C: Strong association of unesterified [3H]docosahexaenoic acid and [3H-docosahexaenoyl] phosphatidate to rhodopsin during in vivo labeling of frog retinal rod outer segments. Neurochem Res (2000) 25:695-703.
Gordon, W.C., Colangelo, V., Bazan N.G., Klatzo, I: Aspects of the maturation phenomenon observed by the TUNEL method. In:, Maturation Phenomenon in Cerebral Ischemia III (I to U et al, eds). pp 15-23. Springer-Verlag: Berlin, (1999).
Gordon, W.C. and Bazan, N.G: Retina. In: Biochemistry of the Eye. John J. Harding (ed). Chapman and Hall, London (1997). pp. 144-275.
Bazan, N.G., Gordon, W.C., Marcheselli, V.L., Lukiw, W.J., Duhault, J., Koenig-Berard, E., Linn, D.M., DeCoster, M.A., Mukherjee, P.K: Experimental models and their use in studies of diabetic retinal microangiopathy. Thrapie (1997) 52:447-451.
Gordon, W.C., Bazan, N.G: Visualization of [3H]docosahexaenoic acid trafficking through photoreceptors and retinal pigment epithelium by electron microscopic autoradiography. Invest Ophthalmol Vis Sci (1993) 34:2402-2411.
Rodriguez de Turco, E.B., Gordon, W.C., and Bazan, N.G. Light stimulates in vivo inositol lipid turnover in frog retinal pigment epithelial cells at the onset of shedding and phagocytosis of photoreceptor membranes. Exp. Eye Res. (1992) 55:719-725.
Gordon, W.C., Rodriguez de Turco, E.B., and Bazan, N.G. Retinal pigment epithelial cells play a central role in the conservation of docosahexaenoic acid by photoreceptor cells after shedding and phagocytosis. Current Eye Res. (1992) 11:73-83.
Dahl, N.A. and Gordon, W.C. Photomembrane turnover in frog: Light intensity and spectral correlates. Exp. Eye. Res. (1992) 55:839-852.
Baudouin, C., Peyman, G., Fredj‑Reygrobellet, D., Gordon, W.C., Lapalus, P., Gastaud, P., and Bazan, N.G. Immunohistological study of subretinal membranes in age‑related macular degeneration. Jpn. J. Ophthalmol. (1992) 36:443-451.
Baudouin, C., Fredj‑Reygrobellet, D., Peyman, G., Lapalus, P., Gordon, B., Bazan, N.G., and Gastaud, P. Etude immunohistologique des membranes néovasculaires sous-rétiniennes au cours des dégénérescences maculaires liées à l’âge. Ophtalmolgie. (1991) 5:61-64.
Rodriguez de Turco, E.B., Gordon, W.C., and Bazan, N.G. Rapid and selective uptake, metabolism, and differential distribution of docosahexaenoic acid among rod and cone photoreceptor cells in the frog retina. J. Neurosci. (1991) 11:3667-3678.
Baudouin, C., Gordon, W.C., Fredj‑Reygrobellet, D., Baudouin, F., Peyman, G., Gastaud, P., and Bazan, N.G. Class II antigen expression in diabetic preretinal membranes. Am. J. Ophthalmol. (1990) 109:70‑74.
Baudouin, C., Gordon, W.C., Fredj‑Reygrobellet, D., Baudouin, F., Peyman, G., Gastaud, P., and Bazan, N.G. Expression von Klasse‑II‑Antigen in diabetischen praretinalen Membranen. Ophthalmol. Digest. (1990) 4:7‑8.
Gordon, W.C. and Dahl, N.A. Light absorbed by 575‑cones triggers rod disc shedding in the frog retina. Vis. Neurosci. (1990) 4:95‑98.
Baudouin, C., Gastaud, P., Gordon, W.C., Lapalus, P., Bazan, N.G., Righini, M., and Peyman, G.A. Etude immunohistologique des membranes épirétiniennes au cours de la rétinopathie diabétique proliférative et du décollement de rétine avec prolifération vitréo‑rétinienne. Ophtalmologie. (1990) 4:53‑55.
Browman, H.I., Gordon, W.C., Evans, B.I., and O'Brien, W.J. Correlation between histological and behavioral measures of visual acuity in a zooplanktivorous fish, the white crappie (Pomoxis annularis). Brain, Behavior, and Evolution. (1990) 35:85‑97.
Gordon, W.C. and Bazan, N.G. Docosahexaenoic acid utilization during rod photoreceptor cell renewal. J. Neurosci. (1990) 10:2190‑2202.
Baudouin, C., Fredj‑Reygrobellet, D., Gordon, W.C., Baudouin, F., Peyman, G., Lapalus, P., Gastaud, P., and Bazan, N.G. Immunohistologic study of epiretinal membranes in proliferative vitreoretinopathy. Am. J. Ophthalmol. (1990) 110:593‑598.
Rodriguez de Turco, E.B., Gordon, W.C., and Bazan, N.G. Preferential uptake and metabolism of docosahexaenoic acid in membrane phospholipids from rod and cone photoreceptor cells of human and monkey retinas. J. Neurosci. Res. (1990) 27:522‑532.
Gordon, W.C. and Keith, M.E. D‑Tubocurarine chloride inhibits rod outer segment shedding in the frog retina. Invest. Ophthalmol. Vis. Sci. (1987) 28:118‑120.
Basinger, S.F. and Gordon, W.C. Local stimulation induces shedding throughout the frog retina. Vision Res. (1982) 22:1533‑1538.
Basinger, S.F., Gordon, W.C., and Lam, D.M.K. Differential labeling of retinal neurons by 3H‑2‑deoxyglucose. Nature. (1979) 280:682‑684.
Defense Advanced Research Projects Agency (DARPA)
Bio-magnetics interfacing concepts: A microfluidic system using magnetic nanoparticles for quantitative detection of biological species.
University of New Orleans,
Advanced Materials Research Institute College of Science
(PI, C.J. O’Connor),
LSU Neuroscience Center of Excellence
(PI, N.G. Bazan),
LSU Center for Advanced Microstructures and Devices
(PI, F. Hormes).
LSU Neuroscience Center - Nanobiotechnological approaches to laser-induced retinal damage. Retinal protection against laser-induced injury.
(April 2003, a 5-year program).
Retinal pigment epithelium messengers, transcription, and photoreceptor renewal.
National Institutes of Health/National Eye Institute.
(Co-PI with N.G. Bazan)