William C. Gordon, PhDLSUHSC School of Medicine – Neuroscience Center of Excellence

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	William C. Gordon, PhD Associate Professor Research LSUHSC Neuroscience Center of Excellence Floor 6, Room 608 2020 Gravier Street, Suite D New Orleans, LA 70112 Phone: (504) 599-0881 Fax: (504) 599-0891 wgordo@lsuhsc.edu http://www.medschool.lsuhsc.edu/faculty/docs/Neuroscience Retreat Brochure - Gordon - CV 090210 (2).pdf
Degrees	1977-1980: Postdoc (Ophthalmology); Baylor College of Medicine, Houston, TX 1970-1977: PhD (Biology); University of South Florida, Tampa, FL 1968-1970: MSc (Biology) (all but thesis); SUNY, Fredonia 1966-1968: BSc (Biology); SUNY, Fredonia, NY 1964-1967: ASc; Jamestown Comm College, Jamestown, NY
Bio	Awards/Recognitions: 2006: Distinguished Alumnus Award; Jamestown Community College, Jamestown, NY 1987: Nominated Teacher of the Year; University of Kansas, Lawrence, KS 1977-1980: NRSA Postdoctoral Fellowship; Baylor College of Medicine, (SF Basinger, preceptor) 1967: Inducted into Beta Beta Beta, the Biological Honor Society; SUNY, Fredonia, NY
Clinical Interests	Current Research: Retinal Inflammation and Neovascularization in a Murine Model of Age-related Macular Degeneration Age-related Macular Degeneration (AMD) is a disease in which photoreceptors in the central region of the human retina begin to degenerate. As the disease slowly progresses, the resulting central blind spots expand, fuse, and eventually lead to clinical blindness. A hallmark of this disease is the compromise of Bruch’s membrane behind the retina and its associated monolayer of retinal pigment epithelial (RPE) cells, which leads to the growth of capillaries (neovascularization) from the choriocapillaris at the back of the eye into the spaces between the RPE and photoreceptors. This spreading disruption triggers photoreceptor cell death. There are at least two components of this disease: inflammation (both initial and chronic) and neovascularization. Our working hypothesis is that regulation or inhibition of these processes will attenuate or halt the spread of photoreceptor death across the retina. We induce choroidal neovascularization (CNV) in the mouse retina by producing a small hole through the RPE and Bruch’s membrane with an ophthalmic laser. Initial inflammatory processes are observed, followed by the invasion of new capillaries into the retina. We follow these events by measuring the amount of blood leakage into the retina at the lesion sites with angiography. After two weeks, the retina/RPE/choroidal complex is collected as a whole mount and immunolocalization performed to delineate new retinal endothelial cells. Image stacks through each lesion site are collected by confocal microscopy, three-dimensional reconstructions are made, and total capillary volumes calculated. A group of metabolic metabolites, derived from two omega-3 fatty acids, eicospentaenoic acid and docosahexaenoic acid (EPA and DHA), produce a series of compounds, the resolvins, in the presence of specific lipoxygenases. These are anti-inflammatory and anti-neovascular. Our study involves treatment with these compounds throughout the two-week CNV interval, followed by analysis of the new capillary volumes within the retina at each lesion site, and comparisons with untreated controls.
Research Interests	Keywords: cell biology of retina and hippocampus under normal and pathological conditions, neuronal cell death and neuroprotection Research Interests: Retinal morphology, physiology, and biochemistry - Mitochondrial response during photoreceptor stress - Mechanisms of photoreceptor cell death and protection - Information processing for retinal maintenance
Teaching Activities	2004 – present: Associate Professor, Research; Ophthalmology and Neuroscience, LSU Health Sciences Center, New Orleans, LA 1994-2004: Assistant Professor, Research; Department of Ophthalmology and Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, LA 1987-1994: Instructor; Department of Ophthalmology and Neuroscience Center of Excellence, LSU Medical Center, New Orleans, LA 1981-1987: Assistant Professor; Department of Physiology & Cell Biology, University of Kansas, Lawrence, KS 1980-1987: Assistant Professor; Department of Entomology, University of Kansas, Lawrence, KS 1977-1980: Postdoctoral Fellow; Department of Ophthalmology, Baylor College of Medicine, Houston, TX 1975-1977: Instructor; Department of Biology, Hillsborough Community College, Tampa, FL 1970-1977: Graduate Research Assistant; Dept of Biology, University of South Florida, Tampa, FL 1968-1970: Graduate Research Assistant; Archbold Biological Station, Lake Placid, FL; Summer 1968, 1969 Smithsonian Tropical Research Institute, Barro Colorado Island, Panama Canal Zone; Summer 1970 1966-1970: Director of Planetarium; State University of New York, Fredonia, NY
Selected Publications	Relevant Papers and Chapters: Belayev L, Khoutorova L, Atkins K, Gordon WC, Alvarez-Builla J, Bazan NG. 2008. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. 214:253-258. Mukherjee, P.K., Marcheselli, V.L., Vaccari, J.CdR., Gordon, W.C., Jackson, F., Bazan, N.G. 2007. Photoreceptor outer segment phagocytosis selectively attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. PNAS, USA. 104:13158-13163. Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G. 2005. Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Exp Eye Res. 81:742-750. Colangelo, V., Gordon, W.C., Mukherjee, P.K., Trivedi, P., Ottino, P. 2004. Downregulation of COX-2 and JNK expression after induction of ischemic tolerance in the gerbil brain. Brain Res. 1016:195-200. Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G. 2003. DNA repair in photoreceptor survival. Molecular Neurobiol. 28:111-122. Gordon, W.C., Casey D.M., Lukiw, W.J., Bazan, N.G. 2002. DNA damage and repair in light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci. 43:3511-3521. Gordon, W.C. and Bazan, N.G. 1997. Retina. In: Biochemistry of the Eye. John J. Harding (ed). Chapman and Hall, London. pp. 144-275. Selected Papers: Cortina MS, Gordon WC, Lukiw WJ, Bazan NG: Light-induced photoreceptor damage triggers DNA repair: Differential fate of rods and cones, Retinal Degenerations: Mechanism and Experimental Therapy (LaVail MM, Hollyfield JG, Anderson RE, eds) Pp 229-240. Kluwer Academic/Plenum Publishers: New York, 2003. Lukiw WJ, Gordon WC, Rogaev EI, Thompson H, Bazan NG: Presenilin-2 (PS-2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis. Molecular Neuroscience 12:53-57, 2001. Rodriguez de Turco EB, Jackson FR, Parkins N, Gordon WC: Strong association of unesterified [3H]docosahexaenoic acid and [3H-docosahexaenoyl] phosphatidate to rhodopsin during in vivo labeling of frog retinal rod outer segments. Neurochem Res 25:695-703, 2000. Gordon WC, Colangelo V, Bazan NG, Klatzo I: Aspects of the maturation phenomenon observed by the TUNEL method. In:, Maturation Phenomenon in Cerebral Ischemia III (Ito U et al, eds). Pp 15-23. Springer-Verlag: Berlin, 1999. Bazan NG, Gordon WC, Marcheselli VL, Lukiw WJ, Duhault J, Koenig-Berard E, LinnDM, DeCoster MA, Mukherjee PK: Experimental models and their use in studies of diabetic retinal microangiopathy. Thrapie 52:447-451, 1997. Gordon WC, Bazan NG: Visualization of [3H]docosahexaenoic acid trafficking through photoreceptors and retinal pigment epithelium by electron microscopic autoradiography. Invest Ophthalmol Vis Sci 34:2402-2411, 1993.
Additional Info	Recent Funding: Defense Advanced Research Projects Agency (DARPA) Bio-magnetics interfacing concepts: A microfluidic system using magnetic nanoparticles for quantitative detection of biological species. University of New Orleans, Advanced Materials Research Institute College of Science (PI, C.J. O’Connor), LSU Neuroscience Center of Excellence (PI, N.G. Bazan), LSU Center for Advanced Microstructures and Devices (PI, F. Hormes). LSU Neuroscience Center - Nanobiotechnological approaches to laser-induced retinal damage. Retinal protection against laser-induced injury. (April 2003, a 5-year program). Retinal pigment epithelium messengers, transcription, and photoreceptor renewal. National Institutes of Health/National Eye Institute. (Co-PI with N.G. Bazan)

William C. Gordon, PhD

Associate Professor Research