Jiucheng He, MD, PhDLSUHSC School of Medicine – Neuroscience Center of Excellence

Administration	Basic Sciences	Clinical Sciences	Centers of Excellence
Admissions Alumni Affairs Community and Minority Health Education Computer Support Continuing Education Dean's Office Faculty & Institutional Affairs Fiscal Affairs Libraries Medical Education Research Student Affairs	Biochemistry & Molecular Biology Cell Biology & Anatomy Genetics Microbiology, Immunology & Parasitology Pharmacology Physiology	Anesthesiology Dermatology Family Medicine Internal Medicine Emergency Medicine Gastroenterology Physical Medicine & Rehabilitation Neurology Neurosurgery OB/GYN Ophthalmology Orthopaedics Otorhinolaryngology Pathology Pediatrics Psychiatry Radiology Surgery Urology	Alcohol and Drug Abuse Center Cardiovascular Center Center on Healthy Aging Center for Molecular and Human Genetics Epilepsy Center Eye Center Ernest N. Morial Asthma, Allergy, and Respiratory Disease Center Gene Therapy Program Low Vision Center Neurosciences Center The Research Institute For Children Stanley S. Scott Cancer Center

Department Title

Spotlight Section

New Orleans

Faculty

Research

Graduate Programs

Calendar

Administration

Gifts and Giving

Awards Recognitions

Patents

Selected Former Faculty

	Jiucheng He, MD, PhD Research Assistant Professor of Ophthalmology and Neuroscience 2020 Gravier Street, Suite D New Orleans, LA 70112 Phone: (504) 599-0890 jhe@lsuhsc.edu http://www.medschool.lsuhsc.edu/faculty/docs/Jiucheng He-brochure.pdf
Degrees	1983: MD - Hengyang Medical College of Nanhua University 1988: MS - Shanxi Medical University 1999: PhD - Kyoto Prefectuaral University of Medicine 2001-2004: Postdoc - LSUHSC Neuroscience Center of Excellence
Bio	Academic Membership: 1988 to 2001: Member of Chinese Ophthalmological Society 1994 to 1999: Member of Japan Cornea Society. Since 1997: Member of Association for Research in Vision and Ophthalmology
Clinical Interests	Current Research Projects: 1. The effect of LAU-0901 treatment on the expression of inflammatory mediators and Arginase II in the cornea under desiccating conditions after PRK. 2. The molecular and cellular mechanisms of retrocorneal membrane and the effect of cytokines and growth factors on endothelial differentiation and proliferation. 3. Platelet activating factor (PAF)-induced angiogenic response in corneal myofibroblasts. 4. The molecular mechanisms of corneal nerve regeneration after lamellae keratectomy.
Research Interests	Keywords: mechanisms of corneal wound healing, corneal myofibroblast biology Current Research 1. The molecular and cellular mechanisms of corneal wound healing 2. The molecular mechanisms of corneal nerve regeneration after injury 3. Human corneal nerve architecture in normal and disease conditions Research Interests: The roles of stromal cells and corneal nerves in maintaining corneal transparency and integrity.
Teaching Activities	2007 – present: Research assistant professor of Ophthalmology and Neuroscience; Neuroscience Center, LSUHSC, New Orleans, LA 2005-2007: Research Instructor of Ophthalmology and Neuroscience; Neuroscience Center, LSU HSC, New Orleans, LA 2001-2004: Postdoc, Neuroscience Center, LSU HSC, New Orleans, LA 1999-2001: Associate Professor and Deputy Director of Laboratory, Beijing Institute ofOphthalmology, Beijing, China 1994-1995: SASAKAWA Medical Scholarship Visitor in the Department of Ophthalmologyof Kyoto Prefectural University of Medicine, Kyoto, Japan 1990-1994: Physician-in-charge and lecturer of Ophthalmology in the First Affiliated Hospital of University of South China. Hengyang, China 1988-1989: Cornea Fellow in the Eyebank Center of Gongzhou Medical College. Gongzhou, China 1985-1988: Resident and postgraduate in the Department of Ophthalmology in the SecondAffiliated Hospital of Sanxi Medical University, Taiyuan, China 1983-1985: Resident in the First Affiliated Hospital of University of South China
Selected Publications	Recent Papers: 1. M. Soledad Cortina, Jiucheng He, Na Li, Nicolas G. Bazan and Haydee E.P. Bazan. PEDF plus DHA Induces Neuroprotectin D1 Synthesis and Corneal Nerve Regeneration after Experimental Surgery. Invest Ophthalmol Vis Sci. 2009 (Submitted) 2. Jiucheng He, Haydee E.P. Bazan: Epidermal growth factor (EGF) Synergism with TGF-1 via PI-3 kinase activity in corneal keratocyte differentiation. Invest Ophthalmol Vis Sci. 2008; 49: 2936-2945. 3. Salomon Esquenazi, Isi Esquenazi, Lev Grunstein, Jiucheng He, Haydee E. P. Bazan. Immunohistological evaluation of the healing response at the flap interface in patients with LASIK ectasia requiring penetrating keratoplasty. Journal of Refractive Surgery. 2008 (accepted) 4. Salomon Esquenazi, Jiucheng He, Na Li, Nicolas G Bazan, William J Rand, Haydee, EP Bazan. Comparative in vivo high-resolution confocal microscopy of corneal epithelium, sub-basal nerves and stroma in mice with and without dry eye after PRK. Clinical & Experimental ophthalmology. 2007;35:545-549 5. Almamoun Abdelkader, Salomon Esquenazi, Haydee EP Bazan, Jiucheng He, Steve Gill, Herbert Kaufman. Healing Process at the Flap Edge and its Influence in the Development of Corneal Ectasia after LASIK. Current Eye Research. 2007; 31:903-908. 6. Jiucheng He, Haydee E.P. Bazan: Synergistic Effect of Platelet-activating Factor and Tumor Necrosis Factor-α on Corneal Myofibroblast Apoptosis. Investigative Ophthalmology & Visual Science. 2006; 47(3): 883-891 7. Salomon Esquenazi, Jiucheng He, Dooho B. Kim, Nicolas G. Bazan, Viet Bui, Haydee E. P. Bazan. Wound healing response and refractive regression after conductive keratoplasty. J Cataract Refract Surg. 2006; 32(3): 480-486 8. Jiucheng He, Nicolas G. Bazan, Haydee E.P. Bazan: Alkali-induced corneal stromal melting prevention by a novel platalet activating factor (PAF) receptor antagonist. Arch Ophthalmol. 2006(1) ; 124:70-78. 9. Paulo Ottino, Jiucheng He, Thomas W. Axelrad, and Haydee E. P. Bazan. PAF-induced furin and MT1-MMP expression is independent of MMP-2 activation in corneal myofibroblasts. Invest Ophthalmol Vis Sci. 2005; 46(2): 487-496. 10. Salomon Esquenazi, Haydee E. P. Bazan, Viet Bui, Jiucheng He, Dooho B. Kim, Nicolas G. Bazan. Topical combination of NGF and DHA increases rabbit corneal generation after PRK. Invest Ophthalmol Vis Sci. 2005;46(9):3121-3127. 11. Salomon Esquenazi, Jiucheng He, Haydee E. P. Bazan, Nicolas G. Bazan. Use of autologous serum in corneal epithelial defects post lamellar surgery. Cornea. 2005; 24:992-997. 12. Salomon Esquenazi, Jiucheng He, Nicolas G. Bazan, Haydee E. P. Bazan. Comparison of corneal wound healing response in PRK and LASEK. J Cataract Refract Surg. 2005; 31: 1632-1639. 13. Salomon Esquenazi, H. Sprague Eustis, Haydee E.P.Bazan, Alejandro Leon, Jiucheng He. Corneal Keloid in Lowe Syndrome. J Pediatr Opthalmol Strabismus. 2005; 42:308-310. 14. Salomon Esquenazi, Jiucheng He, Haydee E. P. Bazan, Nicolas G. Bazan. Prevention of experimental diffuse lamellar keratitis using a novel platelet-activating factor receptor antagonist. J Cataract Refract Surg. 2004; 30: 884-891. 15. Guru-Dutt Sharma, Jiucheng He, and Haydee E. P. Bazan. P38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing. J Biol Chem. 2003; 278: 21989-21997. 16. Jie Yu, Liuhe Zhou, Jiucheng He, et al. Mutation Analysis in BIGH3 Gene in Chinese Patients with Corneal Dystrophies. Journalof Chinese Ophthalmology. 2003;39(10):64-72. (Chinese) 17. Jiucheng He, Xiaohong Zheng, Chie Sotozono and Shigeru Kinoshita. Prevention of corneal neovascularization by a synthetic inhibitor of metalloproteinase (SIMP). Chin Ophthalmol Res. 2001; 17:436-441.(Chinese) 18. Akiko Niiya, Norihiko Yokoi, Yasuhiro Matsumoto, Aoi Komuro, Takeshi Ishibashi, Satoshi Tomii, Jiucheng He and Shigeru Kinoshita. Effect of beta-blocker eyedrops on corneal epithelial barrier function. Ophthalmologica. 2000; 214: 332-336. 19. Jiucheng He, Hiroshi Ichimura, Tohko Iida, Masato Minami, Kappei Kobayashi, Masakazu Kita, Chie Sotozono, Yoh-Ichi Tagawa, Yoichiro Iwakura, and Jiro Imanishi. Kinetics of cytokine production in the cornea and trigeminal ganglion of C57BL/6 mice after corneal HSV-1 infection. Journal of Interferon & Cytokine Research. 1999; 19:609-615. 20. Chie Sotozono, Jiucheng He, Mamoru Tei, Yoich Honma, and Shigeru Kinoshita. Effect of metalloproteinase inhibitor on corneal cytokine expression after alkali injury. Investigative Ophthalmology and Visual Science. 1999; 40(10):2430-2434. 21. Jiucheng He. The persistent expression of interferon-γ in the HSV-1-infected murine trigeminal ganglion. Journal of Kyoto Prefectural University of Medicine. 1999; 108:135-143. (Japanese)