LSU Health New Orleans

Departments & Centers | Contact | Donate

Administration Basic Sciences Clinical Sciences Centers of Excellence


song hong new for web 031213

Song Hong, Ph.D.

Associate Professor of Research, Neuroscience and Ophthalmology

LSUHSC - Neuroscience Center of Excellence
8th floor, Room 8A7
2020 Gravier St., Suite D
New Orleans, LA 70112

Phone: (504) 599-0838 (O);

(504) 599-0335 (lab)



1996-2001: Postdoctoral training - Cornell University,
New York

1996: PhD - The University of Georgia




2012-present: Associate Professor of Neuroscience and Ophthalmology.
Neuroscience Center of Excellence,
LSU Health Sciences Center, New Orleans, LA

2006-2012: Assistant Professor of Neuroscience and Ophthalmology.
Neuroscience Center of Excellence,
LSU Health Sciences Center, New Orleans, LA 

2004-2006: Instructor, Harvard Medical School, Boston, MA

2001-2004: Research fellow, Harvard Medical School, Boston, MA

Clinical Interests

Current Research:

1) The roles of reparative lipid mediators and lipidomic pathways in diabetic wound healing, neuropathy, and nephropathy, as well as ocular diseases. 2) The key cells involved in these roles, including macrophages, stem cells, endothelial cells, epithelial cells, fibroblasts, and neural cells. 3) The key cellular and molecular processes involved, including inflammation, phagocytosis/efferocytosis, vascularization/angiogenesis, fibrosis, and innervation. 


fig 7 High Resolution




Research Interests


Wound healing, chronic wounds impaired by diabetes and aging, diabetic neurophathy, nerve regeneration and degeneration, resolution of chronic inflammation, pro-healing lipid autacoids, pro-resolving reparative lipid mediators, mediator-lipidomic pathways, vasculogenesis, angiogenesis, fibrosis, phagocytosis, efferocytosis, wound healing, wound breaking strength, scarring, diabetic nephropathy, renal acute injury, leukocytes, macrophages, monocytes, dendritic cells, neutrophils, mesenchymal stem cells, adipose stem cells, platelets, endothelial cells, epithelial cells, and T-cells.


Research Interests and Goals:

Our long term goals are: 1) To delineate the actions, roles, and mechanisms of lipid mediators and mediator-lipidomic pathways that regulate wound healing and other reparative processes impaired by diabetes and aging. 2) To provide new targets for better treatment of diabetic complications. Our short-term goals are: 1) To elucidate the mechanism of action of endogenous pro-healing lipid mediators in diabetic impairments of wound healing, vascularization, and innervation. We will also determine lipid-mediator based signatures of human non-healing chronic wounds. 2) To study the interaction of lipid mediators and stem cells or leukocytes in chronic wounds. 3) To study lipid mediators in ocular diseases.

Teaching Activities


Selected Publications

Key Peer-reviewed Publications
(Selected from 57 peer-reviewed publications)

1. Hong, S. *; Tian, H.; Lu, Y.; Laborde, J. M.; Muhale, F. A.; Wang, Q.; Alapure, B. V.; Serhan, C. N.; Bazan, N. G., Neuroprotectin/Protectin D1: Endogenous Biosynthesis and Actions on Diabetic Macrophages in Promoting Wound Healing and Innervation Impaired by Diabetes.Am J Physiol Cell Physiol, 2014, 307, (11): C1058-67. PMCID: PMC4254953. PMID: 25273880. (*Corresponding author)


2. Hong, S.*; Lu, Y.; Tian, H.; Alapure, B. V.; Wang, Q.; Bonnell, B.; Laborde, J. M., Leukocytes and Platelets Produce Novel Maresin-like Docosanoids Structure, Biosynthesis, and Effect on Diabetes-impaired Macrophage Reparative Function.Chemistry & Biology (Cell at Cell Press), 2014, 21, (10): 1318-29. PMCID: PMC4224612. PMID:25200603. (*Corresponding author)


3. Hong, S.*; Alapure, B. V.; Lu, Y.; Tian, H.; Wang, Q., 12/15-Lipoxygenase deficiency reduces densities of mesenchymal stem cells in the dermis of wounded and unwounded skin. Br J Dermatol2014, 171, (1), 30-8. PMCID:PMC4114990. PMID: 24593251. (*Corresponding author)


4. Hong, S*.; Alapure, B. V.; Lu, Y.; Tian, H.; Wang, Q., Immunohistological localization of endogenous unlabeled stem cells in wounded skin. J Histochem Cytochem2014, 62, (4), 276-85. PMCID: PMC3966289. PMID: 24399040.(*Corresponding author)


5. Hong, S.*; Lu, Y., Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury. Front Immunol 2013, 4, 13. PMCID:PMC3558681. PMID: 23386851. (*Corresponding author)


6. Tian, H.; Lu, Y.; Shah, S. P.; Wang, Q.; Hong, S.*, 14S,21R-dihydroxy-docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury. Stem Cells Dev 2012, 21, (7), 1187-99. PMCID:PMC3328765. PMID: 21846180. (*Corresponding author)


7.  Bazan, N. G.; Eady, T. N.; Khoutorova, L.; Atkins, K. D.; Hong, S.; Lu, Y.; Zhang, C.; Jun, B.; Obenaus, A.; Fredman, G.; Zhu, M.; Winkler, J. W.; Petasis, N. A.; Serhan, C. N.; Belayev, L., Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol 2012, 236, (1), 122-30. PMCID: PMC3409566. PMID: 22542947.


8. Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. Am J Pathol 2011, 179, (4), 1780-91.PMCID:PMC3181353. PMID: 21839062.(*Corresponding author)


9.  Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, 14S,21R-Dihydroxydocosahexaenoic Acid Remedies Impaired Healing and Mesenchymal Stem Cell Functions in Diabetic Wounds.J Biol Chem 2011, 286, (6), 4443-53. PMCID:PMC3039401. PMID: 21112969. (*Corresponding author)


10.  Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Novel 14S,21-dihydroxy-docosahexaenoic acid rescues wound healing and associated angiogenesis impaired by acute ethanol intoxication/exposure.J Cell Biochem2010, 111, (2), 266-73. PMCID:PMC3308707. PMID: 20506249. (*Corresponding author)


11.  Lu, Y.; Tian, H.; Hong, S.*, Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing. J Lipid Res2010, 51, (5), 923-32. PMCID:PMC2853460. PMID:19965612. (*Corresponding author)


12.  Marcheselli, V. L.; Mukherjee, P. K.; Arita, M.; Hong, S.; Antony, R.; Sheets, K.; Winkler, J. W.; Petasis, N. A.; Serhan, C. N.; Bazan, N. G., Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot Essent Fatty Acids 2010, 82, (1), 27-34. PMCID:PMC2822836.PMID: 19931440,


13.  Tian, H.; Lu, Y.; Sherwood, A. M.; Hongqian, D.; Hong, S.*, Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions. Invest Ophthalmol Vis Sci2009, 50, (8), 3613-20. PMID:19443724. (*Corresponding author)

14.  Hong, S.; Porter, T. F.; Lu, Y.; Oh, S. F.; Pillai, P. S.; Serhan, C. N., Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol 2008, 180, (5), 3512-9. PMID:18292578.

15.  Bazan, N. G.; Marcheselli, V. L.; Lu, Y.; Hong, S.; Jackson, F., Lipidomic Approaches to Neuroprotection Signaling in the Retinal Pigment Epithelium. In Signal Transduction in the Retina, Fliesler, S. J.; Kisselev, O. G., Eds. CRC Press: 2007; pp 345-374.


16.  Hong, S.; Lu, Y.; Yang, R.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. J Am Soc Mass Spectrom2007, 18, (1), 128-44. PMCID:PMC2763184. PMID:17055291.


17.  Lu, Y.*; Hong, S.*; Yang, R.; Uddin, J.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms. Rapid Commun Mass Spectrom 2007, 21, (1), 7-22.  PMID:17131464.(*Share 1st authorship).


18.  Connor, K. M.; SanGiovanni, J. P.; Lofqvist, C.; Aderman, C. M.; Chen, J.; Higuchi, A.; Hong, S.; Pravda, E. A.; Majchrzak, S.; Carper, D.; Hellstrom, A.; Kang, J. X.; Chew, E. Y.; Salem, N., Jr.; Serhan, C. N.; Smith, L. E., Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med 2007, 13, (7), 868-73. PMID:17589522.

19.  Lu, Y.*; Hong, S.*; Gotlinger, K.; Serhan, C. N., Lipid mediator informatics and proteomics in inflammation resolution. ScientificWorldJournal 2006, 6, 589-614. PMID: 16752008. (*Share 1st authorship)

20.  Serhan, C. N.; Gotlinger, K.; Hong, S.; Lu, Y.; Siegelman, J.; Baer, T.; Yang, R.; Colgan, S. P.; Petasis, N. A., Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol 2006, 176, (3), 1848-59. PMID: 16424216.

21.  Duffield, J. S. *; Hong, S. *; Vaidya, V. S.; Lu, Y.; Fredman, G.; Serhan, C. N.; Bonventre, J. V., Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol 2006, 177, (9), 5902-11, PMID: 17056514. PMID: 17056514. (*Share 1st authorship)

22.  Hong, S.; Tjonahen, E.; Morgan, E. L.; Lu, Y.; Serhan, C. N.; Rowley, A. F., Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins Other Lipid Mediat 2005, 78, (1-4), 107-16. PMID: 16303609.

23.  Lu, Y.*; Hong, S.*; Tjonahen, E.; Serhan, C. N., Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators. J Lipid Res 2005, 46, (4), 790-802. PMID:15722568. (*Share 1st authorship)

24.  Arita, M.; Bianchini, F.; Aliberti, J.; Sher, A.; Chiang, N.; Hong, S.; Yang, R.; Petasis, N. A.; Serhan, C. N., Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 2005, 201, (5), 713-22. PMCID:PMC2212834. PMID:15753205.


25.  Ariel, A.; Li, P. L.; Wang, W.; Tang, W. X.; Fredman, G.; Hong, S.; Gotlinger, K. H.; Serhan, C. N., The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. J Biol Chem 2005, 280, (52), 43079-86. PMID:16216871.

26. Vance, R. E.; Hong, S.; Gronert, K.; Serhan, C. N.; Mekalanos, J. J., The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc Natl Acad Sci U S A 2004, 101, (7), 2135-9. 17. PMCID:PMC357064. PMID:14766977.


27.  Marcheselli, V. L.*; Hong, S.*; Lukiw, W. J.; Tian, X. H.; Gronert, K.; Musto, A.; Hardy, M.; Gimenez, J. M.; Chiang, N.; Serhan, C. N.; Bazan, N. G., Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 2003, 278, (44), 43807-17. PMID:12923200. (*Share 1st authorship)

28. Hong, S.; Gronert, K.; Devchand, P. R.; Moussignac, R. L.; Serhan, C. N., Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 2003, 278, (17), 14677-87. PMID:12590139.

29.  Serhan, C. N.; Hong, S.; Gronert, K.; Colgan, S. P.; Devchand, P. R.; Mirick, G.; Moussignac, R. L., Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.J Exp Med 2002, 196, (8), 1025-37. PMCID:PMC2194036. PMID:12391014.