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song hong new for web 031213

Song Hong, Ph.D.

Associate Professor/Research Neuroscience and Ophthalmology

LSUHSC - Neuroscience Center of Excellence
8th floor, Room 8A7
2020 Gravier St., Suite D
New Orleans, LA 70112

Phone: (504) 599-0838 (O);

(504) 599-0335 (lab)


Song Hong website pdf


1996-2001: Postdoctoral training - Cornell University,
New York

1996: PhD - The University of Georgia




2012-present: Associate Professor of Neuroscience and Ophthalmology.
Neuroscience Center of Excellence,
LSU Health Sciences Center, New Orleans, LA

2006-2012: Assistant Professor of Neuroscience and Ophthalmology.
Neuroscience Center of Excellence,
LSU Health Sciences Center, New Orleans, LA 

2003-2006: Instructor, Harvard Medical School, Boston, MA

2001-2002: Research fellow, Harvard Medical School, Boston, MA

Clinical Interests

Current Research:

The typical pathways that we have studied are presented as follows:

Lipidomic pathways, in macrophages, endothelial cells, epithelial cells, and organs,
for the biosynthesis of omega-3 essential fatty acids derived lipid-mediators that
regulate inflammation, angiogenesis, fibrosis, wound healing, and nephropathy
affected by diabetes; as well as modulate ocular diseases.


Research Interests

lipidomic pathways, omega-3 essential fatty acids, DHA, EPA, angiogenesis, fibrosis, inflammation, wound healing, diabetic nephropathy and neuropathy, macrophages, dendritic cells, T-cells, endothelial cells, epithelial cells

Research Interests and Goals:

To delineate lipidomic pathways that regulate inflammation, angiogenesis, fibrosis, wound healing, nephropathy, and neuropathy in diabetes. To provide new targets for the development of better treatment of diabetic complications.

Teaching Activities


Selected Publications

Key Peer-reviewed Publications
(Selected from 50 peer-reviewed publications)

  1. Hong, S.*; Lu, Y., Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury.Front Immunol 2013, 4, 13. (*Corresponding author)
  2. Tian, H.; Lu, Y.; Shah, S. P.; Wang, Q.; Hong, S.*, 14S,21R-dihydroxy-docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury.Stem Cells Dev 2012, 21, (7), 1187-99. (*Corresponding author)
  3. Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions.Am J Pathol 2011, 179, (4), 1780-91. (*Corresponding author)
  4. Duffield, J. S.*; Hong, S.*; Vaidya, V. S.; Lu, Y.; Fredman, G.; Serhan, C. N.; Bonventre, J. V., Resolvin D series and protectin D1 mitigate acute kidney injury.J Immunol 2006, 177, (9), 5902-11. (*Share 1st authorship)
  5. Hong, S.; Gronert, K.; Devchand, P. R.; Moussignac, R. L.; Serhan, C. N., Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation.J Biol Chem 2003, 278, (17), 14677-87.
  6. Bazan, N. G.; Eady, T. N.; Khoutorova, L.; Atkins, K. D.; Hong, S.; Lu, Y.; Zhang, C.; Jun, B.; Obenaus, A.; Fredman, G.; Zhu, M.; Winkler, J. W.; Petasis, N. A.; Serhan, C. N.; Belayev, L., Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol 2012, 236, (1), 122-30.
  7. Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, 14S,21R-Dihydroxydocosahexaenoic Acid Remedies Impaired Healing and Mesenchymal Stem Cell Functions in Diabetic Wounds.J Biol Chem 2011, 286, (6), 4443-53. (*Corresponding author)
  8. Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Novel 14S,21-dihydroxy-docosahexaenoic acid rescues wound healing and associated angiogenesis impaired by acute ethanol intoxication/exposure.J Cell Biochem 2010, 111, (2), 266-73. (*Corresponding author)
  9. Lu, Y.; Tian, H.; Hong, S.*, Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing.J Lipid Res 2010, 51, (5), 923-32. (*Corresponding author)
  10. Tian, H.; Lu, Y.; Sherwood, A. M.; Hongqian, D.; Hong, S.*, Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions.Invest Ophthalmol Vis Sci 2009, 50, (8), 3613-20. (*Corresponding author)
  11. Hong, S.; Porter, T. F.; Lu, Y.; Oh, S. F.; Pillai, P. S.; Serhan, C. N., Resolvin E1 metabolome in local inactivation during inflammation-resolution.J Immunol 2008, 180, (5), 3512-9.
  12. Bazan, N. G.; Marcheselli, V. L.; Lu, Y.; Hong, S.; Jackson, F., Lipidomic Approaches to Neuroprotection Signaling in the Retinal Pigment Epithelium. In Signal Transduction in the Retina, Fliesler, S. J.; Kisselev, O. G., Eds. CRC Press: 2008; pp 345-374.
  13. Hong, S.; Lu, Y.; Yang, R.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms.J Am Soc Mass Spectrom 2007, 18, (1), 128-44.
  14. Lu, Y.*; Hong, S.*; Yang, R.; Uddin, J.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms. Rapid Commun Mass Spectrom 2007, 21, (1), 7-22. (*Share 1st authorship)
  15. Lu, Y.*; Hong, S.*; Gotlinger, K.; Serhan, C. N., Lipid mediator informatics and proteomics in inflammation resolution.ScientificWorldJournal 2006, 6, 589-614. (*Share 1st authorship)
  16. Xia, S.; Lu, Y.; Wang, J.; He, C.; Hong, S.; Serhan, C. N.; Kang, J. X., Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids.Proc Natl Acad Sci U S A 2006, 103, (33), 12499-504.
  17. Hudert, C. A.; Weylandt, K. H.; Lu, Y.; Wang, J.; Hong, S.; Dignass, A.; Serhan, C. N.; Kang, J. X., Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis.Proc Natl Acad Sci U S A 2006, 103, (30), 11276-81.
  18. Serhan, C. N.; Gotlinger, K.; Hong, S.; Lu, Y.; Siegelman, J.; Baer, T.; Yang, R.; Colgan, S. P.; Petasis, N. A., Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.J Immunol 2006, 176, (3), 1848-59.
  19. Hong, S.; Tjonahen, E.; Morgan, E. L.; Lu, Y.; Serhan, C. N.; Rowley, A. F., Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis.Prostaglandins Other Lipid Mediat 2005, 78, (1-4), 107-16.
  20. Lu, Y.*; Hong, S.*; Tjonahen, E.; Serhan, C. N., Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators.J Lipid Res 2005, 46, (4), 790-802. (*Share 1st authorship)
  21. Arita, M.; Bianchini, F.; Aliberti, J.; Sher, A.; Chiang, N.; Hong, S.; Yang, R.; Petasis, N. A.; Serhan, C. N., Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.J Exp Med 2005, 201, (5), 713-22.
  22. Ariel, A.; Li, P. L.; Wang, W.; Tang, W. X.; Fredman, G.; Hong, S.; Gotlinger, K. H.; Serhan, C. N., The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering.J Biol Chem 2005, 280, (52), 43079-86.
  23. Vance, R. E.; Hong, S.; Gronert, K.; Serhan, C. N.; Mekalanos, J. J., The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.Proc Natl Acad Sci U S A 2004, 101, (7), 2135-9. 17.
  24. Marcheselli, V. L.*; Hong, S.*; Lukiw, W. J.; Tian, X. H.; Gronert, K.; Musto, A.; Hardy, M.; Gimenez, J. M.; Chiang, N.; Serhan, C. N.; Bazan, N. G., Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.J Biol Chem 2003, 278, (44), 43807-17. (*Share 1st authorship)
  25. Serhan, C. N.; Hong, S.; Gronert, K.; Colgan, S. P.; Devchand, P. R.; Mirick, G.; Moussignac, R. L., Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.J Exp Med 2002, 196, (8), 1025-37.
Additional Info

“Neuroprotectins and Maresins for Macrophages in Diabetic Wound Healing”

Principal Investigator: Song Hong, Ph.D.
Agency: NIH, NIDDK (1R01DK087800).
Period: 04/01/10-03/31/15