Song Hong, PhDLSUHSC School of Medicine – Neuroscience Center of Excellence

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	Song Hong, PhD Assistant Professor of Ophthalmology and Neuroscience LSUHSC - Neuroscience Center 8th floor, Room 8A7 2020 Gravier St., Suite D New Orleans, LA 70112 Phone: (504) 599-0838 (O); (504) 599 0335 (lab) shong@lsuhsc.edu Lipidomic pathways generate eicosapentaenoic acid (EPA)-derived lipid-mediators that regulate inflammation, angiogenesis, and choroid neovascularization. http://www.medschool.lsuhsc.edu/faculty/docs/Song Hong website neuroscience retreat 3-13-2009a.pdf
Degrees	1996: PhD - The University of Georgia 1996-2001: Postdoctoral training - Cornell University, New York
Clinical Interests	Current Research: We use lipidomic approaches to define pro- and anti-inflammatory mediators in laser-induced choroidal neovascularization and molecular and cellular mechanisms to elucidate the bioactivity of lipid mediators. We also study lipidomes in angiogenesis.
Research Interests	Keywords: lipidomic pathways, DHA, EPA, angiogenesis, inflammation, choroid neovascularization, neurological and retinal diseases, links to genomes and proteomes Research Interests and Goals: Lipidomic pathways that regulate inflammation, angiogenesis, and choroid neovascularization. Lipid biochemistry and biology related to human health and diseases including retinal degeneration. Research Project: Lipidomic approach to define pro- and anti-inflammatory mediators in laser-induce choroidal neovascularization molecular and cellular mechanisms for the bioactions of lipid mediators.
Teaching Activities	2006-present: Assistant Professor of Ophthalmology and Neuroscience; Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 2001-2006: Instructor, Harvard Medical School, Boston, MA
Selected Publications	Key Recent Papers: Bazan NG, Marcheselli VL, Lu Y, Hong S, Jackson F: Lipidomic Approaches to Neuroprotection Signaling in the Retinal Pigement Epithelium. Signal Transduction in the Retina. Edited by Fliesler SJ & Kisselev OG, CRC Press, 2008. Hong S, Porter TF, Lu Y, Oh SF, Pillai PS, Serhan SN: Resolvin E1 Metabolome in Local Inactivation During Inflammation-Resolution. J Immunol 180:3512-3519, 2008 Hong S, Lu Y, Yong R, Gotlinger KH, Pertasis NP, Serhan CN: Resolvin D1, Protectin D1, and Related Docosahexaenoic Acid-Derived Products: Structure Analysis via Electrospray/Low Energy Tandem Mass Spectrometry Based on Spectra and Fragmentation Mechanisms. Journal of the American Society for Mass spectrometry. 18:128-144, 2007 Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S, Arita M, Serhan CN: Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis, Chem Biol 13:1193-202, 2007. Connor KM, Sangiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N Jr, Serhan CN, Smith LE: Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis, Nat Med 13:868-73, 2007. Duffield JS, Hong S*, Vaidya V, Lu Y, Fredman G, Serhan CN, Bonventre JV: Endogenous Anti-inflammatory Omega-3 Lipid Mediators Resolvin D and Protectin D1 Mitigate Acute Kidney Injury, J Immunol* 177:5902-11, 2006. Xia S, Wang J., Lu Y, Hong S, Serhan C.N., Kang J.X, The Growth of Melanoma is Inhibited in Fat-1 Transgenic Mice: Impact of n-6/n-3 Essential Fatty Acids, Proc Natl Acad Sci USA 103:12499-504, 2006. Hudert CA, Weylandt KH, Lu Y, Wang J, Hong S, Dignass A, Serhan CN, Kang JX, Transgenic Mice Rich in Endogenous n-3 Fatty Acids are Protected from Colitis, Proc Natl Acad Sci. USA 103:11276-81, 2006. Lu Y, Hong S*, Gotlinger KH, Pertasis NA, Serhan CN, Lipid Mediator Informatics and Proteomics in Inflammation and Its Resolution, The Scientific World Journal* 6:589-614, 2006. Arita M, Yoshida M, Hong S, Tjonahen E, Glickman JN, Petasis NA, Blumberg RS, Serhan CN, Resolvin E1, A Novel Endogenous Lipid Mediator Derived from Omega-3 Eicosapentaenoic Acid, Protects against TNBS-induced Colitis, Proc Natl Acad Sci USA 102:7671-76, 2005. Lu Y, Hong S*, Tjonahen E, Serhan CN, Mediator-lipidomics: Databases and Search Algorithms for PUFA-derived Mediators, Journal of Lipid Research* 46:790-802, 2005. Vance RE, Hong S, Gronert K., Serhan CN, Mekalanos JJ., The Opportunistic Pathogen Pseudomonas Aeruginosa Carries A Secretable Arachidonate 15-Lipoxygenase, Proc. Natl. Acad. Sci. USA 101:2135-2139, 2004. Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN., Novel Docosatrienes and 17S-resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood and Glial Cells: Autacoids in Anti-inflammation, J. Biol. Chem. 278:14677-14687, 2003. Marcheselli VL, Hong S*, Lukiw WJ, Tian XH, Gronert K, Musto A, Gimenez JM, Chiang N, Serhan CN, Bazan NG, Novel Docosanoids Inhibit Brain Ischemia-reperfusion-mediated Leukocyte Infiltration and Pro-Inflammatory Gene Expression, J. Biol. Chem* 278:43807-43817, 2003. Devechand PR, Arita M, Hong S, Bannenberg, G, Moussignac RL, Gronert, K, Serhan CN, Human ALX Receptor Regulates Neutrophil Recruitment in Transgenic Mice: Roles in Inflammation and Host Defense, FASEB J 17:652-659, 2003. Serhan CN, Hong S, Gronert K, Colgan SP, Devchand, PR, Mirick G, Moussignac R., Resolvins: A Family of Bioactive Products of Omega-3 Fatty Acid Transformation Circuits Initiated by Aspirin Treatment that Counter Proinflammation Signals, J. Experimental Medicine. 2002, 196:1025-1037. Selected Publications: Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN: Protectin D1 is generated in asthma and dampens airway inflammation and hyper-responsiveness, J Immunol 178:496-502, 2007. Arita M, Oh S, Chonan T, Hong S, Elangovan S, Sun S, Uddin J: Petasis NA, Serhan CN, Metabolic Inactivation of Resolvin E1 and Stabilization of its Anti-Inflammatory Actions, J. Biol. Chem. 28: 22847-22854, 2006. Hong S, Tjonahen E, Morgan EL, Lu Y, Serhan CN, Rowley AF: Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins - mediator lipidomic analysis, Prostaglandins Other Lipid Mediat 78:107-16, 2005. Devechand PR, Arita M, Hong S, Bannenberg, G, Moussignac RL, Gronert, K, Serhan CN: Human ALX Receptor Regulates Neutrophil Recruitment in Transgenic Mice: Roles in Inflammation and Host Defense, FASEB J 17:652-659, 2003.