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Song Hong, Ph.D.
Associate Professor/Research Neuroscience and Ophthalmology
LSUHSC - Neuroscience Center of Excellence
8th floor, Room 8A7
2020 Gravier St., Suite D
New Orleans, LA 70112
Phone: (504) 599-0838 (O);
(504) 599-0335 (lab)
shong@lsuhsc.edu
Song Hong website pdf
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| Degrees |
1996-2001: Postdoctoral training - Cornell University,
New York
1996: PhD - The University of Georgia
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| Bio |
Positions
2012-present: Associate Professor of Neuroscience and Ophthalmology.
Neuroscience Center of Excellence,
LSU Health Sciences Center, New Orleans, LA
2006-2012: Assistant Professor of Neuroscience and Ophthalmology.
Neuroscience Center of Excellence,
LSU Health Sciences Center, New Orleans, LA
2003-2006: Instructor, Harvard Medical School, Boston, MA
2001-2002: Research fellow, Harvard Medical School, Boston, MA
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| Clinical Interests |
Current Research:
The typical pathways that we have studied are presented as follows:
Lipidomic pathways, in macrophages, endothelial cells, epithelial cells, and organs,
for the biosynthesis of omega-3 essential fatty acids derived lipid-mediators that
regulate inflammation, angiogenesis, fibrosis, wound healing, and nephropathy
affected by diabetes; as well as modulate ocular diseases.
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| Research Interests |
Keywords:
lipidomic pathways, omega-3 essential fatty acids, DHA, EPA, angiogenesis, fibrosis, inflammation, wound healing, diabetic nephropathy and neuropathy, macrophages, dendritic cells, T-cells, endothelial cells, epithelial cells
Research Interests and Goals:
To delineate lipidomic pathways that regulate inflammation, angiogenesis, fibrosis, wound healing, nephropathy, and neuropathy in diabetes. To provide new targets for the development of better treatment of diabetic complications.
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| Teaching Activities |
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NEURO 203, INVESTIGATIVE NEUROSCIENCE
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NCE 290, SPECIAL TOPICS
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| Selected Publications |
Key Peer-reviewed Publications
(Selected from 50 peer-reviewed publications)
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Hong, S.*; Lu, Y., Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury.Front Immunol 2013, 4, 13. (*Corresponding author)
- Tian, H.; Lu, Y.; Shah, S. P.; Wang, Q.; Hong, S.*, 14S,21R-dihydroxy-docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury.Stem Cells Dev 2012, 21, (7), 1187-99. (*Corresponding author)
- Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions.Am J Pathol 2011, 179, (4), 1780-91. (*Corresponding author)
- Duffield, J. S.*; Hong, S.*; Vaidya, V. S.; Lu, Y.; Fredman, G.; Serhan, C. N.; Bonventre, J. V., Resolvin D series and protectin D1 mitigate acute kidney injury.J Immunol 2006, 177, (9), 5902-11. (*Share 1st authorship)
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Hong, S.; Gronert, K.; Devchand, P. R.; Moussignac, R. L.; Serhan, C. N., Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation.J Biol Chem 2003, 278, (17), 14677-87.
- Bazan, N. G.; Eady, T. N.; Khoutorova, L.; Atkins, K. D.; Hong, S.; Lu, Y.; Zhang, C.; Jun, B.; Obenaus, A.; Fredman, G.; Zhu, M.; Winkler, J. W.; Petasis, N. A.; Serhan, C. N.; Belayev, L., Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol 2012, 236, (1), 122-30.
- Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, 14S,21R-Dihydroxydocosahexaenoic Acid Remedies Impaired Healing and Mesenchymal Stem Cell Functions in Diabetic Wounds.J Biol Chem 2011, 286, (6), 4443-53. (*Corresponding author)
- Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Novel 14S,21-dihydroxy-docosahexaenoic acid rescues wound healing and associated angiogenesis impaired by acute ethanol intoxication/exposure.J Cell Biochem 2010, 111, (2), 266-73. (*Corresponding author)
- Lu, Y.; Tian, H.; Hong, S.*, Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing.J Lipid Res 2010, 51, (5), 923-32. (*Corresponding author)
- Tian, H.; Lu, Y.; Sherwood, A. M.; Hongqian, D.; Hong, S.*, Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions.Invest Ophthalmol Vis Sci 2009, 50, (8), 3613-20. (*Corresponding author)
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Hong, S.; Porter, T. F.; Lu, Y.; Oh, S. F.; Pillai, P. S.; Serhan, C. N., Resolvin E1 metabolome in local inactivation during inflammation-resolution.J Immunol 2008, 180, (5), 3512-9.
- Bazan, N. G.; Marcheselli, V. L.; Lu, Y.; Hong, S.; Jackson, F., Lipidomic Approaches to Neuroprotection Signaling in the Retinal Pigment Epithelium. In Signal Transduction in the Retina, Fliesler, S. J.; Kisselev, O. G., Eds. CRC Press: 2008; pp 345-374.
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Hong, S.; Lu, Y.; Yang, R.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms.J Am Soc Mass Spectrom 2007, 18, (1), 128-44.
- Lu, Y.*; Hong, S.*; Yang, R.; Uddin, J.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms. Rapid Commun Mass Spectrom 2007, 21, (1), 7-22. (*Share 1st authorship)
- Lu, Y.*; Hong, S.*; Gotlinger, K.; Serhan, C. N., Lipid mediator informatics and proteomics in inflammation resolution.ScientificWorldJournal 2006, 6, 589-614. (*Share 1st authorship)
- Xia, S.; Lu, Y.; Wang, J.; He, C.; Hong, S.; Serhan, C. N.; Kang, J. X., Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids.Proc Natl Acad Sci U S A 2006, 103, (33), 12499-504.
- Hudert, C. A.; Weylandt, K. H.; Lu, Y.; Wang, J.; Hong, S.; Dignass, A.; Serhan, C. N.; Kang, J. X., Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis.Proc Natl Acad Sci U S A 2006, 103, (30), 11276-81.
- Serhan, C. N.; Gotlinger, K.; Hong, S.; Lu, Y.; Siegelman, J.; Baer, T.; Yang, R.; Colgan, S. P.; Petasis, N. A., Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.J Immunol 2006, 176, (3), 1848-59.
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Hong, S.; Tjonahen, E.; Morgan, E. L.; Lu, Y.; Serhan, C. N.; Rowley, A. F., Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis.Prostaglandins Other Lipid Mediat 2005, 78, (1-4), 107-16.
- Lu, Y.*; Hong, S.*; Tjonahen, E.; Serhan, C. N., Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators.J Lipid Res 2005, 46, (4), 790-802. (*Share 1st authorship)
- Arita, M.; Bianchini, F.; Aliberti, J.; Sher, A.; Chiang, N.; Hong, S.; Yang, R.; Petasis, N. A.; Serhan, C. N., Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.J Exp Med 2005, 201, (5), 713-22.
- Ariel, A.; Li, P. L.; Wang, W.; Tang, W. X.; Fredman, G.; Hong, S.; Gotlinger, K. H.; Serhan, C. N., The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering.J Biol Chem 2005, 280, (52), 43079-86.
- Vance, R. E.; Hong, S.; Gronert, K.; Serhan, C. N.; Mekalanos, J. J., The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.Proc Natl Acad Sci U S A 2004, 101, (7), 2135-9. 17.
- Marcheselli, V. L.*; Hong, S.*; Lukiw, W. J.; Tian, X. H.; Gronert, K.; Musto, A.; Hardy, M.; Gimenez, J. M.; Chiang, N.; Serhan, C. N.; Bazan, N. G., Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.J Biol Chem 2003, 278, (44), 43807-17. (*Share 1st authorship)
- Serhan, C. N.; Hong, S.; Gronert, K.; Colgan, S. P.; Devchand, P. R.; Mirick, G.; Moussignac, R. L., Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.J Exp Med 2002, 196, (8), 1025-37.
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| Additional Info |
Funding:
“Neuroprotectins and Maresins for Macrophages in Diabetic Wound Healing”
Principal Investigator: Song Hong, Ph.D.
Agency: NIH, NIDDK (1R01DK087800).
Period: 04/01/10-03/31/15
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