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| Degrees |
1991: Medicine. School of Medicine, Universidad de Buenos Aires (UBA), Argentina (AR) |
| Bio |
2007- present: Assistant Professor-Research in Neuroscience and Neurosurgery, Louisiana State University, Health Sciences Center, New Orleans, LA. 2002-2006: Postdoctoral Fellow, Louisiana State University, Health Sciences Center, New Orleans, LA USA, Neuroscience Center of Excellence. 2001-2002: Senior Chief. Medical Image Department. Sanatorio Guemes. Buenos Aires. AR 1999-2000: Chief of MRI and CT Division. Medical Image Department. Sanatorio Guemes. Buenos Aires. AR 1998-2002: Assistant Professor. Internal Medicine Department. Neurology Division. Hospital Municipal de San Isidro. AR. 1996-2002: Assistant Professor, Lecturer on Human Anatomy, Anatomy Department, School of Medicine. Universidad Austral, Pilar, AR 1995-1998: Resident of Neurology. Internal Medicine Department. Neurology Division. Hospital Municipal de San Isidro. AR 1994-1998: Research Fellowship: Tesis research conducted by scholarship from CONICET at Instituto de Neurobiologia. AR. 1992-1994: Neurophysiology Research Assistant, Neurobiology Institute, Consejo de Investigación Científica y Tecnológica (CONICET), Buenos Aires, AR. 1992-2002: Assistant Professor. Anatomy Department, School of Medicine, Universidad de Buenos Aires, AR |
| Research Interests |
The long-term goal is to understandthe molecular and cellular mechanisms of how the normal brain develops an impaired neuronal network and degenerative process during epileptogenesis. Using a combination of experimental approaches, I can identify the critical factors involve in the genesis of epileptic seizures. These results will be translated into alternative therapeutics pathways for treatment of epilepsy. Current research: Dr. Alberto E. Musto’s laboratory is focusing in the basic mechanism/s that mediates the genesis of seizures (ictiogenesis) and the occurrence of spontaneous seizures (epileptogenesis). The central hypothesis is that failure of inhibitory neurotransmition mediated by GABAa receptors lead to the initiation and propagation of seizures. Several repetitive seizures enhance the accumulation of platelet activacting factor (PAF) that activates molecular pathways, which triggers inflammatory and degenerative process in the brain (Fig 1). Dr. Musto tests the mentioned hypothesis integrating his background of clinical neurology and neuroradiology into in vivo animal models of experimental epilepsy, using behavioral procedures, state of the art of electrophysiology in vivo, immunohistology techniques, biochemical protocols and novel chemical compounds (LAU-0901). Dr. Musto’s laboratory hypothesizes that modulation of PAF activity through the PAF-antagonist receptor, LAU-0901, the neuroinflammation, neuronal damage and recurrent epileptic seizures will be attenuated. Dr. Musto collaborates with Dr. Nicolas G. Bazan in studying neuroprotective signaling in experimental epilepsy.
Figure 1: Proposed mechanism of the basic process involved in ictiogenesis and epileptogenesis. Spectral profile from hippocampal EEG of induced partial seizure (1) and generalized seizures (2) associated with morphological changes in hippocampus using Tim’s staining (3,4); Somatostatin IR for interneuronal cells (5,6). Generalized seizure is mediated by loss of GABAA agonism and is associated with aberrant mossy fiber sprouting (4) and loss of SOM (6). 7:Local field potential (LFP) from dorsal hippocampus through silicon probe with multi-array electrode at different days before and after status epilepticus. LFP changes from stratum pyramidal(upper traces) and molecular layer (lower traces) of CA1. Epileptiform, interictal and ictal activity associated with disruption of amplitude ratio of these layers are observed during epileptogenesis. These electrophysiological changes are associated with PAF accumulation (8) that induces JNK and in turn increases PGE2 (8) through COX-2 activation and c-jun gene expression. Hippocampal consequences of these activated molecular pathways: microgliosis (9), degenerative neurons (10) and loss of SOM interneurons(11). |
| Teaching Activities |
Alberto Musto Lab
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| Selected Publications |
Key Papers: Musto, AE, M.S. Sammi, J.F. Hayes. Different phases of afterdischarge during rapid kindling procedure in mice Epilepsy Research, (in press) 2009. Musto, A.E.., M. Hardy, F.R. Jackson, M.S. Samii, B. B. Chiappinelli, H. Thompson, V.L. Marcheselli Attenuation of epileptogenesis by hippocampal neuroprotectin D1 synthesis. Bazan, N.G., (In revision, 2008) Bazan, N.G. and Musto, A.E. Inositol lipid signaling in synaptic activity, neuronal plasticity and epileptogenesis. Encyclopedia of Basic Research in Epilepsy, Elsevier, 2009 (in press). Cole-Edwards K.K., Musto A.E., Bazan N.G. c-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes.. J Neurosci. 2006 Aug 9; 26:8295-304. Musto, A.E., Bazan N.G.Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis. Epilepsia. 2006 Feb; 47 (2): 267-76. Lukiw, W.J., Cui,J.G., Musto, A.E., Musto, B.C., Bazan, N.G. Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus.. Biochem Biophys Res Commun. 2005 Dec 9; 338:77-81. Musto, A.E., Hardy, M. and Bazan, N.G. Arachidonoyl-Inositol Lipid Signaling is required for Hippocampal Excitability in Kindling Epileptogenesis.. Neurobiology of Lipids, Vol. 3, 4, 2004 Mc Dermott, C.M., LaHoste, G.J., Chen, C., Musto, AE., Bazan, N.G., Magee, J.C. Sleep deprivation causes behavioral, synaptic and membrane excitability alterations in hippocampal neurons. J Neurosci. 2003 Oct 22;23: 9687-95 Selected Papers: Bazan, N.G., Musto, A.E., Inositol lipid signaling in synaptic activity, neuronal plasticity and epileptogenesis. Encyclopedia of Basic Epilepsy Research, in Press, 2008. Musto, A.E., Different EEG patterns and oscillations are evoked during kindling, (Ready to be submitted to Experimental Neurology), 2008. Musto, A.E., Development and regeneration of the mistacial pad of the rat and its correlation with the locomotor behavior., Doctoral thesis, Library of Universidad de Buenos Aires, School of Medicine, 2002. Granillo, R. and Musto, A.E., Clinical study of Epilepsy in the Hospital San Isidro, 1997. Musto, A.E., Suburo, A., Granillo, R., Tramezzani, J.H., Sequential differentiation of the nerves in the postnatal rat vibrissae as revealed by PGP 9.5., Comunicaciones Biolgicas 14:243, 1996. Cardinali, D. et al. Colaborator: Musto, A.E. and Cella, L., Neurociencias y Salud Mental. Biblioteca medica digital, ISBN: 987-9212-40-1 CD. Data Vision S.A,.
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| Additional Info |
Present Funding:
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