Website Picture_Xiaolin Tian-p Xiaolin Tian, Ph.D.
 Assistant Professor of Research, Neuroscience, Cell Biology and Anatomy

 2020 Gravier Street, Suite D
 New Orleans, LA 70112

 Office: (504) 559-0912

 Lab: (504) 568-2057

 Fax: (504) 599-0891

 xtian@lsuhsc.edu

 

Degrees     

2000 – 2006:  Ph.D. in Developmental Biology,
Washington University in St. Louis, School of Medicine, USA
1992 – 1996:  B. S. in Biochemistry,
East China University of Science and Technology
Shanghai, China.                          

 

Bio

Feb, 2016 – Present     Assistant Professor-Research
Neuroscience Center & Department of Cell Biology and Anatomy
Louisiana State University Health Sciences Center 

Aug, 2014 – May, 2015 Adjunct Instructor
Department of Biological Sciences
University of New Orleans

Jan, 2009 – Jan, 2016   Postdoc, Neuroscience Center
Louisiana State University Health Sciences Center

Jun. 2007 – Dec. 2008  Postdoc, Department of Pathology and Immunology,
Washington University in St. Louis, School of Medicine

Research Interests

Cellular degradation pathways help maintain cell homeostasis and promote normal development, differentiation and aging. Malfunction in the clearance mechanisms contributes to a range of human diseases including neural developmental and neurodegenerative disorders. The goal of my research is to understand how lysosome-mediated autophagy and ubiquitin proteasome system, the two major cellular clearance mechanisms, promote the development and degeneration of our nervous system.

Keywords

Autophagy, Lysosomal Function, Aging. Neural Development, Neurodegeneration, Drosophila Model System.

Selected publications

Xiaolin Tian and Chunlai Wu. (2015) Active zone stability: insight from fly neuromuscular junction. Neural Regeneration Research. 10, 677-678. PMID: 26109929. PMCID: PMC4468746.

Mingwei Zhu, Xiaolin Tian* and Chunlai Wu*. (2015) Mask loss-of-function rescues mitochondrial impairment and muscle degeneration of Drosophila pink1 and parkin mutants. Human Molecular Genetics pii: ddv081, PMID: 25743185, (* Corresponding author).

Xiaolin Tian, Mingwei Zhu, Long Li and Chunlai Wu. Identifying protein-protein interaction in Drosophila Adult heads by tandem affinity purification (TAP).The Journal of Visualized Experiments (JOVE) (2013) 82, e50968, doi:10.3791/50968

Xiaolin Tian and Chunlai Wu. The role of ubiquitin-mediated pathways in presynaptic development and axonal regeneration.The Journal of Physiology (2013) 591(Pt 13):3133-43 (* Corresponding author)

Xiaolin Tian, Jing Li, Vera Valakh, Aaron DiAntonio and Chunlai Wu. Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Nature Neuroscience (2011)14, 1267-1275. Featured Article (October, 2011)

Xiaolin Tian, Ramon U. Jin, Andrew J. Bredemeyer, Edward J. Oates, Katarzyna M. Błażewska, Charles E. McKenna, and Jason C. Mills. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.Molecular and Cellular Biology. (2010) 30(5): 1269-84

Xiaolin Tian, Dave Hansen, Tim Schedl and James B. Skeath. Epsin potentiates Notch pathway activity in Drosophila and C. elegans.Development. (2004) 131(23): 5807-15

Complete List of Published Work in MyBibliography:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/41127296/?sort=date&direction=ascending