Website Picture_Xiaolin Tian-p Xiaolin Tian, Ph.D.
 Assistant Professor – Research, Cell Biology and Anatomy and Neuroscience

 2020 Gravier Street, Suite D
 New Orleans, LA 70112

 Office: (504) 559-0912

 Lab: (504) 568-2057

 Fax: (504) 599-0891

 xtian@lsuhsc.edu

 


Degrees     

2000 – 2006:  Ph.D. in Developmental Biology,
Washington University in St. Louis, School of Medicine, USA

1992 – 1996:  B. S. in Biochemistry,
East China University of Science and Technology
Shanghai, China.                          

 

Short Bio

Feb, 2016 – Present
Assistant Professor-Research
Neuroscience Center of Excellence & Department of Cell Biology and Anatomy
Louisiana State University Health Sciences Center 

Jan, 2009 – Jan, 2016
Postdoctoral Researcher,
Neuroscience Center of Excellence,
Louisiana State University Health Sciences Center

Jun. 2007 – Dec. 2008
Postdoctoral Researcher,
Department of Pathology and Immunology,
Washington University in St. Louis, School of Medicine

 

Research Interests

My research focuses on understanding how specific neurons and neural circuits regulate systemic aging. We recently identified a role of a small population of dopaminergic neurons in regulating longevity in fruit fly. Characterization of the aging-related dopaminergic circuits holds the key to understanding how brain orchestrates aging and lifespan control.

In addition to studying the link between the high-order brain circuits and aging, I am also interested in the cellular degradation pathways that promote cellular homeostasis. Malfunction in the clearance mechanisms contributes to a range of human diseases including neural developmental and neurodegenerative disorders. Our recent studies demonstrated that, Mask, a putative scaffolding protein with RNA binding capacity, regulates lysosome function and autophagic activity. Overexpressing Mask in specific neurons is beneficial to aging and neurodegeneration. Future studies will focus on unravelling the conserved mechanisms through which Mask confers beneficial effects in post mitotic neurons.


Keywords

Aging, Dopaminergic neurons, Neural Development, Neurodegeneration, Autophagy, Lysosomal Function

 

Selected publications

  1. Mingwei Zhu, Sheng Zhang, Xiaolin Tian* and Chunlai Wu*. Mask mitigates MAPT- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification.Autophagy. (2017) 1: 1-15. (* Corresponding author)

  2. Xiaolin Tian and Chunlai Wu. Active zone stability: insight from fly neuromuscular junction.Neural Regeneration Research. (2015)10: 677-678.

  3. Mingwei Zhu, Xia Li, Xiaolin Tian* and Chunlai Wu*.  Mask loss-of-function rescues mitochondrial impairment and muscle degeneration of Drosophila pink1 and parkin mutants. Human Molecular Genetics. (2015) 24(11):3272-85. (* Corresponding author).

  4. Xiaolin Tian, Mingwei Zhu, Long Li and Chunlai Wu. Identifying protein-protein interaction in Drosophila Adult heads by tandem affinity purification (TAP). The Journal of Visualized Experiments (JOVE) (2013) 82, e50968.

  5. Xiaolin Tian and Chunlai Wu. The role of ubiquitin-mediated pathways in presynaptic development and axonal regeneration: insights from fly and worm.The Journal of Physiology (2013) 591(Pt 13):3133-43. (* Corresponding author)

  6. Xiaolin Tian, Jing Li, Vera Valakh, Aaron DiAntonio and Chunlai Wu. Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons.Nature Neuroscience (2011)14: 1267-1275. Featured Article (October, 2011).

  7. Xiaolin Tian, Ramon U. Jin, Andrew J. Bredemeyer, Edward J. Oates, Katarzyna M. Błażewska, Charles E. McKenna, and Jason C. Mills. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.Molecular and Cellular Biology. (2010) 30(5): 1269-84.

  8. Xiaolin Tian, Dave Hansen, Tim Schedl and James B. Skeath. Epsin potentiates Notch pathway activity in Drosophila and C. elegans.Development. (2004) 131(23): 5807-15.
     

Complete List of Published Work in MyBibliography:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection