Residency Pathology - Louisiana State University Medical Center, New Orleans, LA., 1993-1998.

Fellowship - Yale University Medical School, New Haven, CT Hematopathology 7/03 to 6/04

Bio

Dr. Zieske was certified by the American Board of Pathology in Anatomic and Clinical Pathology in 1998 after residency training at LSUHSC in New Orleans. He was Specialty Board Certified in Hematology (Hematopathology) in 2004 after training under Brian Smith M.D. at Yale University School of Medicine. He became a member of the medical honor society Alpha Omega Alpha (AOA) in medical school at LSU in New Orleans and was the recipient of the Medical Alumni Association Osler Award, LSU Medical School class of 1993. He is a dedicated teacher and was the recipient of the Professor of the Year Award for the sophomore class of 2001 and 2002 (LSU, New Orleans) and the Resident Anatomic and Clinical Pathology Teaching Award 2003-2004 (Yale University School of Medicine, Pathology Department). His primary area of research is Cardiovascular Pathology, with particular interest in the natural history and pathogenesis of atherosclerosis. His current research focus concerns the molecular pathogenesis of coronary atherosclerosis.

Clinical Interests

Hematopathology, Surgical Pathology, Molecular Pathology, Laboratory Medicine

Research Interests

Natural history of human atherosclerosis
Pathobiological determinants of atherosclerosis in youth
Molecular mechanisms of atherosclerosis
Prostate Cancer

Selected Publications

Selected Peer-Reviewed Publications

Sloop GD, Fallon KB, Lipscomb G, Takei H, Zieske A. The distribution of oxidatively-modified lysine in the human vasculature. Atherosclerosis 2000; 148:255-263

McGill HC, McMahan A, Herderick EE, Tracy RE, Zieske AW, Strong JP for the PDAY Research Group. Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. Arterioscler Thromb Vasc Biol 2000; 20:836-845.

McGill HC, McMahan CA, Zieske AW, Tracy RE, Malcom GT, Herderick EE, Strong JP for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Association of coronary heart disease risk factors with microscopic qualities of coronary atherosclerosis in youth. Circulation 2000; 102:374-379.

Zieske AW, Malcom GT, Strong JP. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Cardiovascular Specimen and Data Library. J La State Med Soc 2000; 152:296-301.

McGill HC, McManan CA, Zieske AW, Sloop GD, Walcott JV, Troxclair DA, Malcom GT, Tracy RE, Oalmann MC, Strong JP for the PDAY research group. Associations of coronary heart disease risk factors with intermediate lesions of atherosclerosis in youth. Arterioscler Thromb Vasc Biol 2000; 20:1998-2004.

Homma S, Ishii T, Malcom GT, Zieske AW, Strong JP, Tsugane S, Hirose N. Histopathological modifications of early atherosclerotic lesions by risk factors – Findings in PDAY subjects. Atherosclerosis 2001; 156:389-399.

McGill HC Jr, McMahan CA, Zieske AW, Malcom GT, Tracy RE, Strong JP; for the Pathibiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Effects of nonlipid risk factors on atherosclerosis in youth with favorable lipoprotein profile. Circulation 2000;103:1546-1550.

Ishikawa Y, Ishii T, Akasaka Y, Masuda T, Strong JP, Zieske AW, Takei H, Malcom GT, Taniyama M, Choi-Miura CM, Tomita M. Immunolocalization of apolipoproteins in aortic atherosclerosis in American youths and young adults: findings from the PDAY Study. Atherosclerosis 2001;158:215-225.

Strong JP, Zieske AW, Malcom GT. Lipoproteins and atherosclerosis in children: an early marriage? Nutr Metab Cardiovasc Dis 2001;11 Suppl 5:16-22. Review.

Sloop GD, Fallon KF, Zieske AW. Atherosclerotic plaque-like lesions in synthetic arteriovenous grafts:implications for atherogenesis. Atherosclerosis;2002;160:133-139.

Burke AP, Farb A, Pestaner J, Malcom GT, Zieske A, Kutys R, Smialek J, Virmani R. Traditional risk factors and the incidence of sudden coronary death with and without coronary thrombosis in blacks. Circulation. 2002;105:419-24.

Zieske AW, Malcom GT, Strong JP. Natural history and risk factors of atherosclerosis in children and youth; The PDAY Study. Pediatric Pathology and Molecular Medicine 2002;21:1-25

McGill HC, McMahan CA, Herderick EE, Zieske AW, Malcom GT, Tracy RE, Strong JP. Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation 2002;105:2712-2718.

Burke AP, Tracy RP, Kolodgie F, Malcom GT, Zieske AW, Kutys R, Pestaner J, Virmani R. The association of elevated C-reactive protein with atherosclerosis in sudden coronary death: association with different pathologies. Circulation 2002;105:2019-2023.

McGill HC Jr, Herderick EE, McMahan CA, Zieske AW, Malcolm GT, Tracy RE, Strong JP Atherosclerosis in youth. Minerva Pediatr. 2002;54:437-47.

Burke AP, Fonseca V, Kolodgie F, Zieske A, Fink L, Virmani R. Increased homocysteine and sudden death due to coronary atherosclerosis with fibrous plaques. Arteriosc Thromb Vasc Biol 2002;22:1936-1941.

Spanbroek R, Grabner R, Lotzer K, Hildner M, Urbach A, Ruhling K, Moos MP, Kaiser B, Cohnert TU, Wahlers T, Zieske A, Plenz G, Robenek H, Salbach P, Kuhn H, Radmark O, Samuelsson B, Habenicht AJ. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci U S A. 2003;100:1238-43.

Marx N, Walcher D, Raichle C, Aleksic M, Bach H, Grub M, Hombach V, Libby P, Zieske A, Homma S, Strong J. C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. Arterioscler Thromb Vasc Biol. 2004;24:540-545.

Nordskog BK, Blixt AD, Zieske AW, Hellmann GM. MMP-1 polymorphic expression in aortic endothelial cells: possible role in lesion development in smokers and nonsmokers. Cardiovasc Toxicol. 2004;4:75-83.

Burke AP, Kolodgie FD, Zieske A, Fowler DR, Weber DK, Varghese PJ, Farb A, Virmani R. Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study. Arterioscler Thromb Vasc Biol. 2004;24:1266-71.

Zieske A, Smith BR. 2004. Basic Biology of Hematopoietic Progenitor Cell Transplantation. In: "Hematopoietic Progenitor Cells: A Primer for Medical Professionals (Snyder EL, Haley NR, eds), AABB Press.

Walcher D, Aleksic M, Jerg V, Hombach V, Zieske A, Homma S, Strong J, Marx N. C-peptide induces chemotaxis of human CD4-positive cells: involvement of pertussis toxin-sensitive G-proteins and phosphoinositide 3-kinase. Diabetes. 2004;53:1664-70.

Scheer WD, Boudreau DA, Hixson JE, McGill HC, Newman WP 3rd, Tracy RE, Zieske AW, Strong JP. ACE insert/delete polymorphism and atherosclerosis. Atherosclerosis. 2005;178:241-7.

Zieske AW, Tracy R.P., McMahan CA, Herderick E.E., Homma S., Malcom GT, McGill HC Jr, Homma S, and Strong JP for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group . Elevated Serum C-Reactive Protein Levels and Advanced Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol. 2005;25:1237-43.

Zieske AW, McMahan CA, McGill HC Jr, Homma S, Takei H, Malcom GT, Tracy RE, and Strong JP for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group . Smoking Is Associated with Advanced Coronary Atherosclerosis in Youth. Atherosclerosis. 2005;180:87-92.

McMahan CA, Gidding SS, Fayad ZA, Zieske AW, Malcom GT, Tracy RE, Strong JP, McGill HC Jr. Risk scores predict atherosclerotic lesions in young people. Arch Intern Med. 2005;165:883-90.

Homma S, Troxclair DA, Zieske AW, Malcom GT, Strong JP for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Histological topographical comparisons of atherosclerosis progression in juveniles and young adults. Atherosclerosis 2008; 791-798.

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