cASES 11-20

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CASE # 11 CASO # 11

WHAT IS YOUR DIAGNOSIS?
Identify the numbered structures. See the answers by clicking on LESIONS & DIAGNOSIS. CUAL ES SU DIAGNOSTICO?
Identifique las estrcuturas numeradas. Vea las respuestas pulsando sobre LESIONES & DIAGNOSTICO.

CLINICAL INFORMATION: The patient is a 43 year old man with mal absoption disturbances, severe diarrhea, steatorrhea and slight skin pigmentation of two years duration. A duodenal biopsy was obtained.

INFORMACION CLINICA: El paciente es un hombre de 43 años con malabsorcion intestinal, diarrea severa, esteatorrea y debil obscurecimiento de la piel por los dos ultimos años.

Fig 1: Paraffin H&E

Fig 2: Paraffin H&E.

Fig 3: Paraffin PAS

Fig 4: Paraffin PAS.

Fig 5: HRLM (TBBF)

Fig 6: HRLM (TBBF).

Fig 7: TEM

Fig 8: TEM

REFERENCES: Azua-Romero J, Yus C, Alfaro J: Enfermedad de Whipple de manifestacion exclusivamente intestinal. REV ESP Patol 2002; 35:107-111.

Ann Neurol 1997 Jul;42(1):120-4 describes PCR retrieval of Whipple-bacillus sequences from paraffin-embedded duodenal biopsy material.

Durand et al. Whipple Disease: Clinical review of 52 cases, Medicine, vol.26(3), p170, 1997.

http://enotes.tripod.com/whipple.htm

http://www.whipplesdisease.net/Contact/contact.html>http://www.whipplesdisease.net/Contact/contact.html

This website provides information about Whipple´s Disease in the internet. To find what you are looking for, please click the respective buttom in the menue. For questions, please contact: Whipple@vonHerbay.de

COMMENT: The vacuoles (lysosomes) in the foamy macrophages show rod-shaped microorganisms and serpiginous membranes typical of Whipple's disease.

COMENTARIO: Las vacuolas (lisosomas) en los macrófagos contienen microorganismos y abundantes membranas serpiginosas caracteristicas de la enfermedad de Whipple.

PATHIST HRLM-TEM TEACHING CASES		PATHIST MOAR-MET CASOS DE ENSEÑANZA
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CASE # 11		CASO # 11
WHAT IS YOUR DIAGNOSIS? Identify the numbered structures. See the answers by clicking on LESIONS & DIAGNOSIS.		CUAL ES SU DIAGNOSTICO? Identifique las estrcuturas numeradas. Vea las respuestas pulsando sobre LESIONES & DIAGNOSTICO.
CLINICAL INFORMATION: The patient is a 43 year old man with mal absoption disturbances, severe diarrhea, steatorrhea and slight skin pigmentation of two years duration. A duodenal biopsy was obtained.		INFORMACION CLINICA: El paciente es un hombre de 43 años con malabsorcion intestinal, diarrea severa, esteatorrea y debil obscurecimiento de la piel por los dos ultimos años.

Fig 1: Paraffin H&E		Fig 2: Paraffin H&E.

Fig 3: Paraffin PAS		Fig 4: Paraffin PAS.

Fig 5: HRLM (TBBF)		Fig 6: HRLM (TBBF).

Fig 7: TEM		Fig 8: TEM

REFERENCES: Azua-Romero J, Yus C, Alfaro J: Enfermedad de Whipple de manifestacion exclusivamente intestinal. REV ESP Patol 2002; 35:107-111. Ann Neurol 1997 Jul;42(1):120-4 describes PCR retrieval of Whipple-bacillus sequences from paraffin-embedded duodenal biopsy material. Durand et al. Whipple Disease: Clinical review of 52 cases, Medicine, vol.26(3), p170, 1997. *http://enotes.tripod.com/whipple.htm* *http://www.whipplesdisease.net/Contact/contact.html>http://www.whipplesdisease.net/Contact/contact.html* This website provides information about Whipple´s Disease in the internet. To find what you are looking for, please click the respective buttom in the menue. For questions, please contact: *Whipple@vonHerbay.de*
COMMENT: The vacuoles (lysosomes) in the foamy macrophages show rod-shaped microorganisms and serpiginous membranes typical of Whipple's disease.		COMENTARIO: Las vacuolas (lisosomas) en los macrófagos contienen microorganismos y abundantes membranas serpiginosas caracteristicas de la enfermedad de Whipple.

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