PATHIST WEB The Home of High Resolution Light Microscopy (HRLM) La Cuna de Microscopía Optica de Alta Resolución (MOAR)		DEPARTMENT OF PATHOLOGY LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER VETERANS AFFAIRS MEDICAL CENTER NEW ORLEANS, LOUISIANA
DIFFERENT APPROACH FOR THE MORPHOLOGIC STUDY OF THE GLOMERULOPATHIES.		UNA MANERA DIFERENTE PARA ESTUDIAR LA MORFOLOGIA DE LAS GLOMERULOPATIAS.
Check List for SLE Renal Biopsies SLE 7. Check list b		Lista de Verificacion para Biopsias Renales LES 7. Lista verificacion b
Local navigational box.		Caja de Navegacion local.
Glomerulopathies Index	Back to Renal Pathology 2000	Glomerulopatias Indice	Volver a Patologia Renal 2000
SLE 1. Modified classification	SLE 2. Basic lesions	LES 1. Clasificación modificada	LES 2. Lesiones básicas
SLE 3. Active complications	SLE 4. Chronic complications	LES 3. Complicaciones activas	LES 4. Complicaciones crónicas
SLE 5 Pauci-immune nephropathies	SLE 6. Grading-Checklist a	LES 5. Nefropatía Pauci-inmune	LES 6. Grado-Lista comprobación a
SLE 7. Grading-Checklist b	SLE 8. References	LES 7. Grado-Lista comprobación b	LES 8. Referencias.
References: 1. Association of Directors of Anatomic and Surgical Pathology: Standardization of the Surgical Pathology Report. Am J Surg Pathol 16:84-86, 1992. 2. E.O. Hoffmann: Una Clasificacion Practica para la Nefritis Lupica. Cin2000. 3. Check List for SLE Renal Biopsies. Assessment of Activity and Chronicity. Cin2000. http://www.uninet.edu/cin2000.

Modified classification for Lupus Glomerulonephritis with Assessment of Activity and Chronicity
SLE Pleomorphic Panglomerular Glomerulonephritis (SLE PPGN)
Basic (primary) Grade (I-III)	Active complications and grade (AC 0-3)	Active complications and extent (AC %)	Chronic complications and modality (CC1-2)	Chronic complications and extent (CC %)
SLE PPGN grade I (WHO Mesangial) SLE PPGN grade II (WHO Focal Proliferative) SLE PPGN grade III (WHO Difuse Proliferative)	0. No active complications (AC0)		0. No chronic complications (CC0)
	1. Mild AC (AC1)	Focal: < 25% involvement (<25%) Limited: 25-50% involvement (26-50%) Diffuse: >50% involvement (>50%)	1. Patchy	Focal: < 25% involvement (<25%) Limited: 25-50% involvement (26-50%) Diffuse: >50% involvement (>50%)
	2. Moderate AC (AC2)		2. Uniform
	3. Severe AC (AC3)
Examples of PPGN: SLE PPGN basic grade I with mild acute complications in >50% glomeruli. No chronic complications. Extra SLE lesions 0. (SLE PPGN I, AC1 >50%, CC0. Extra SLE 0). SLE PPGN basic grade II with moderate acute complications in < 25% glomeruli. Chronic complications patchy in <50% glomeruli. Underlying diabetic nephropathy (SLE PPGN II, AC2 25-50%, CC1 >50%. Extra SLE ). SLE PPGN basic grade III with severe acute complications in >50% glomeruli. Chronic complications uniform in <25%. Extra SLE 0 (SLE PPGN III, AC3 >50%, CC2 25%. No SINP).
SLE Membranous Glomerulonephritis (SLE MBGN)
SLE MBGN basic grade I (WHO VA) SLE MBGN basic grade II (WHO VB)	0. No active complications (AC0)		0. No chronic complication (CC0)
	1. Mild AC (AC1)	Focal: < 25% involvement (<25%) Limited: 25-50% involvement (26-50%) Diffuse: >50% involvement (>50%)	1. Patchy	Focal: < 25% involvement (<25%) Limited: 25-50% involvement (26-50%) Diffuse: >50% involvement (>50%)
	2. Moderate AC (AC2)		2. Uniform
	3. Severe AC (AC3)
Examples MBGN: SLE MBGN basic grade I with no acute complications but with advanced uniform chronic complications. SLE MBGN I, ACO, CC2>50%. No extra MBGN lesions. SLE MBGN basic grade II with diffuse severe acute complications. No chronic complications. SLE MBGN II, AC3>50%, CC0. No extra MBGN lesions.
SLE Mixed Glomerulonephritis (SLE MXGN)
SLE MXGN. Same basic grades as SLE PPGN.	Same as for PPGN.	Same as for PPGN.	Same as PPGN.	Same as PPGN.
Examples MXGN: SLE MXGN basic grade III with severe acute complications in >50% glomeruli. Early, small chronic complications. No extra SLE lesions. SLE MXGN III, AC3, >50%, CC1, No SINP.

Clasificación modificada para la Glomerulonefritis Lúpica con Evaluación de la Actividad y Cronicidad.
LES Glomerulonefritis Pleomórfica Panglomerular (LES GNPP)
Grado básico (primario)	Complicaciones activas (CA) y grado (1-3).	Complicaciones activas (CA) y extensión (%)	Complicaciones crónicas y modalidad (1-2)	Complicaciones crónicas y extensión (%)
LES GNPP grado I (OMS Mesangial) LES GNPP gado II (OMS Prolif. Focal ) LES GNPP grado III (OMS Prolif. difusa)	0. No Complicación Agúda (CA0)		0. No Complicación crónica (CC0)
	1. Leves (CA1)	Focal: compromete <25% (<25%) Limitada: compromete 26-50% (26-50%) Difusa: compromete >50% (>50%)	En parches	Focal: compromete <25% (<25%) Limitada: compromete 26-50% (26-50%) Difusa: compromete >50% (>50%)
	2. Moderadas (CA2)
			Uniforme
	3. Severas (CA3)
Ejemplos de PPGN: LES GNPP I, CA1, <50%, CC0 = LES GNPP grado básico I con complicaciones agudas leves en <25% glomérulos. No hay complicaciones crónicas. LES GNPP II, CA2, 25-50%, CC3. = LES GNPP grado básico II con complicaciones agudas moderadas en 26-50% de los glomérulos. Hay complicaciones crónicas intermedias. LES GNPP III, CA3, >50%, CC1. = LES GNPP grado básico III con complicaciones agudas severas en >50% de los glomérulos. Hay complicaciones crónicas focales.
LES Glomerulonefritis membranosa (LES GNMB)
LES GNMB grado I (OMS VA) LES GNMB grado II (OMS VB)	0. No CA (CA0)		0. No complicaciones crónicas (CC0).
	1. CA leves (CA1)	Focal: compromete <25% (<25%) Limitada: compromete 26-50% (26-50%) Difusa: compromete >50% (>50%)	En parches	Focal: compromete <25% (<25%) Limitada: compromete 26-50% (26-50%) Difusa: compromete >50% (>50%)
	2. CA moderadas (CA2)
	3. CA severas (CA3)		Uniforme
Ejemplos de GNMB: LES GNMB I, CAO, CC3 = LES GNMB grado básico I sin complicaciones agudas. Hay complicaciones crónicas avanzadas. LES GNMB II, CA3, CC0 = LES GNMB grado básico II con complicaciones agudas severas. No hay complicaciones crónicas.
LES Glomerulonefritis Mixta (LES GNMX)
Los mismos grados básicos que en GNPP (I-III)	Lo mismo que GNPP	Lo mismo que GNPP	Lo mismo que GNPP	Lo mismo que GNPP
Examples MXGN: SLE MXGN basic grade III with severe acute complications in >50% glomeruli. Early, small chronic complications. No extra SLE lesions. SLE MXGN III, AC3, >50%, CC1, No SINP.