Michael S. Lan, PhD

Nelson, B.R., Hartman, B.H., Georgi, S.A., Lan, M.S., and Reh, T.A., Transient inactivation of notch signaling synchronizes differentiation of neural progenitor cells by initiating a cascade of proneural bHLH transcription factor expression, Dev. Biol. Epub, 2007, Jan.

Wang, H.W., Breslin, M.B., and Lan, M.S., Pdx-1 modulates histone H4 acetylation and insulin gene expression in terminally differentiated TC-1 cells, Pancreas 34: 248-253, 2007.

Breslin, M.B., Wang, H.W., Pierce, A., Aucoin, R., and Lan, M.S., Neurogenin 3 recruits CBP co-activator to facilitate histone H3/H4 acetylation in the target gene INSM1, FEBS Lett 581: 949-954, 2007.

Lan, M.S., Wang, H.W., Chong, J., and Breslin, M.B., Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells, Mol. Cell. Biochem. Epub, 2006, Dec.

Liu, W.D., Wang, H.W., Muguira, M. Breslin, M.B.,, INSM1 functions as a transcriptional repressor of the NeuroD/2 gene through the recruitment of cyclin D1 and histone deacetylases, Biochem. J. 397: 169-177, 2006.

Pedersen, N., Pedersen, M.W., Lan, M.S., Breslin, M.B., and Poulsen, H.S., The insulinoma-associated 1: a novel promoter for targeted cancer gene therapy for small cell lung cancer, Cancer Gene Therapy 13: 375-384, 2006.

Mellitzer, G., Bonne, S., Luco, R.F., Van De Casteele M., Lenne, N., Collombat, P., Mansouri, A., Lee, J., Lan, M.S., Pipeleers, D., Nielsen, F.C., Ferrer, J., Gradwohl, G., and Heimberg, H., IA-1 is Ngn3-dependent and essential for differentiation of the endocrine pancreas, EMBO J 25: 1344-1352, 2006.