| Administration | Basic Sciences | Clinical Sciences | Centers of Excellence |
|---|---|---|---|
|
MEDICAL
PHARMACOLOGY
Louisiana State University
Health Sciences Center
School of Medicine
2009
****************************************************************************************************
FROM: E. Songu-Mize, Course Director and Daniel Kapusta Co-Course Director
TO: Medical Class of 2011
SUBJECT: Introduction to the 2009 Sophomore Medical Pharmacology Course, PHARM 200
The simplest definition of pharmacology is that it is the study of chemical agents and their interactions with biological systems. Those agents which are used for therapeutic purposes are nominally called drugs. In addition, pharmacology is also concerned with non-therapeutic agents and their effects on biological systems, i.e., diagnostics, substances of abuse, and toxicants. In this context, the study and mastery of pharmacology provides you with a critical foundation on which to build your clinical skills. Each of you will be prescribing medications throughout your careers as physicians. Hence, each of you has a genuine need to learn basic pharmacological principles and their applications to the evaluation of individual agents. It is the purpose of this course to provide you with the information necessary to achieve those skills.
The following information is a guide to our course. It lists the objectives, means of evaluation and grading system that we will utilize, as well as recommended textbooks, attendance policy, a list of faculty and other elements of the course you need to know. Please note that the second year course directors put a lot of work and special attention into arranging your schedule for this year. This was done to enhance your ability to attend regularly scheduled lectures. We sincerely hope that you will avail yourself to this opportunity.
This is one of the most exciting periods to be in the field of medicine, particularly from a therapeutic perspective. With the completion of the human genome and the establishment of technology platforms in gene arrays and pharmacogenomics, during the course of your career, you will be presented with unprecedented opportunities in terms of understanding disease mechanisms, diagnosis and therapeutics.
SCOPE AND OBJECTIVES
The course is designed to present the student with a broad overview of pharmacology with an emphasis on its application to the practice of medicine. The objective of this presentation is to provide you with a basis for understanding drug actions, desired as well as undesired, so that you will be prepared to use therapeutic agents in a rational manner throughout the span of your practice. Although the importance of basic concepts and principles are recognized, straight facts and their applications must also be learned, and an ability to integrate information concerning one class of drugs with another must be demonstrated. The course content will generally reflect the Knowledge Objectives in Medical Pharmacology as established by the Association for Medical School Pharmacology (AMSP). It should be pointed out that AMSP anticipates that the USMLE Part I will closely reflect these objectives in terms of content.
LECTURES
Our primary means of communication is the lecture. Just about every major lecture series is presented by a faculty member actively pursuing clinical or basic research in the area under discussion. Mainly for this reason, the lectures in this course tend to focus on the leading edge of current thought. Consequently, the lecturer often provides a different perspective than the textbooks and, not infrequently, might disagree with texts.
The lecture series begins with a treatment of general pharmacologic principles that apply to all drugs. This is followed by lectures on specific drug classes, the application of specific agents for the prevention, diagnosis and treatment of disease states. Throughout the course, we will revisit general topics relating to all drug classes by considering such issues as the influences of disease states, age and other factors on drug disposition.
Our philosophy is that drug development changes rapidly while basic principles evolve and change more slowly, and by understanding the latter, you will be able to keep up with the former. Not only does the number of new drugs introduced into medicine continue to expand, but use of older agents endures. In order to live with this expanding number of drugs, we focus our teaching on prototype drugs, pointing out how other agents vary from the most important agents of their class.
CLINICAL CORRELATION CONFERENCES
These conferences are intended to provide a somewhat more informal setting for subjects that we feel are best handled in a more interactive atmosphere. The purpose of these conferences is to acquaint the student with how certain basic principles in pharmacology and specific agents contribute to the treatment of various disease states. In addition, these conferences will provide the student with the opportunity to review drugs previously covered in the course in relation to their use in different patient-care settings. The conferences will be presented by clinical faculty. It should be noted that these conferences are intended to be interactive for the faculty and students. Thus, it is expected that the students will ask questions during these presentations.
SCHEDULE
We try to adhere rigorously to the printed schedule, as many individuals make long-range plans based on it. If and when a schedule change is absolutely necessary, this will be announced at lecture at the earliest possible time. Students who miss these or other announcements due to absence are responsible for obtaining this information.
RECOMMENDED READING
The Department recommends the following books for this course.
1) Goodman & Gilman's The Pharmacological Basis of Therapeutics
available from the library via AccessMedicine. http://www.lsuhsc.edu/no/library/ss&d/data/accessmedicine.html
To access remotely you will need to use your library barcode and PIN.
2) Basic & clinical pharmacology. Edited by Bertram G. Katzung 2007
available electronically via AccessMedicine.
3) Lippincott’s Illustrated Reviews: Pharmacology, 2009 by Finkel.
There is no institutional electronic access to this title, it will be kept on reserve for you in the library (no need to buy it, it is the 3rd preferred text)
Lecture notes and powerpoints will be available on the M-Drive, as well as clicking on the link below where the course schedule is posted.
In addition to the textbooks listed above, there are many excellent sources of information that deal with the clinical aspects of pharmacology that may be of interest to you. These include - but are not limited to - The Medical Letter, The New England Journal of Medicine, Drugs, and Clinical Pharmacology and Therapeutics. These texts are available in the library.
EXAMINATIONS
There will be 3 progress exams and a final examination. The dates and times of the exams are listed on the Lecture and Exam Schedule. The Final Examination will be given on May 8th and will be a shelf exam of the National Board of Medical Examiners.
All progress exams will consist of multiple choice questions from the material presented in lectures, clinical correlations, and in some cases from the suggested reading material. They will be given in the MDLS labs located on the 4th floor of the MEB. The NBME Shelf Examination will begin at 9:00 am and will last for 2.5 hours.
CONDUCT DURING EXAMINATIONS
Traffic during examinations is a distraction. If you must leave, obtain an acknowledgement from a proctor and leave your exam materials with him/her. Also, the proctors will try to keep announcements during exams to minimum.
Each student will be required to sign an Honor Statement before each examination. It is expected that you will uphold this statement and conduct yourself in the appropriate manner.
CHALLENGES
The Department of Pharmacology will not use a challenge system. All Exams will be reviewed by at least 5 faculty members before each exam, and the statistical analysis from the computer center will be used following each exam.
MAKEUP EXAMS
A student who is unable to take any particular scheduled and required examination is expected to notify (by phone or in person) the Department ATONCE. An unexcused absence will result in a grade of ZERO for that exam
EXAMINATION GRADING POLICY
The passing grade for each examination is 1.5 standard deviation units below the class mean or 70%, whichever is lower. Thus a grade of 70% is always passing, irrespective of the class mean.
GRADES
Each exam will be evaluated on a percent basis. Exams will be weighted as follows: Exam 1, 24%; Exam 2, 22%; Exam 3, 29%; Shelf, 25% .
It is our policy to award an “Honors” grade to those students with a final average of 91% or above, a “High Pass” to those with a final average of 80%-90%, and a “Pass” to those with a final average of 70%-79%.
In accordance with the policy of the School of Medicine in New Orleans, the Department reserves the right to re-examine a student at any time to obtain a more-accurate evaluation of the student's knowledge in Medical Pharmacology. After prior notification by the student of a problem related to an exam and at the discretion of the Faculty, a student whose over-all grade in the course is at the level of a near-pass due to poor performance on one of the regularly scheduled examinations may be re-examined on that material. In such cases, the student will be informed in writing of the deficit and in consultation with the Faculty, a remediation program will be established. The nature of the program will be tailored to individual needs of the student. The student will be re-examined on the material by the faculty member(s) directing the remediation. The remediation process must be completed by a date to be announced. At the end of the program, the faculty member(s) overseeing the remedial work will submit a written evaluation to the Department for their consideration and assignment of a final grade. The student will receive a copy of the evaluation. A student who successfully remediates their deficiency will receive a "Pass" grade for the course. A student who does not successfully remediate the deficiency will receive a "Fail" grade for the course.
ATTENDANCE
It is the policy and expectation of the Pharmacology Department that students attend all regularly scheduled class functions. The School of Medicine policy on attendance:
Students are expected to meet the standard of performance as specified by the faculty in each course, including requirements governing attendance at lectures and other course activities. It is expected that students will attend all course activities. Explanation of absence from course activities is to be submitted in writing by the student to the course director or teaching unit involved. When absence from course activities can be anticipated, arrangements should be made in advance with the appropriate faculty member for whatever make-up work may be required. Faculty action concerning student absences should be reported to the Office of Student Affairs and Records for inclusion in the student's file.
NOTE-TAKING SERVICE
Faculty members will, at their discretion, attempt to cooperate with the note-takers in identifying errors and providing clarifications. However, the faculty cannot guarantee perfection in this endeavor and cannot accept responsibility for note-takers' errors. In addition, faculty members will not correct an error of omission.
ADMINISTRATIVE MATTERS
Administrative matters will be handled by the Academic Coordinator in the Department of Pharmacology. The telephone number is 504-568-4740.
One major responsibility of the Course Directors is to see that everyone who needs it, is given the necessary help. Don't hesitate to come to us if you discover you're having difficulty before we do. A faculty member's door is always open to you.
DEPARTMENT OF PHARMACOLOGY MEDICAL COURSE FACULTY
COURSE DIRECTORS:
Emel Songu-Mize, Ph.D., Professor of Pharmacology, emize@lsuhsc.edu
Daniel Kapusta, Ph.D., Professor of Pharmacology, dkapus@lsuhsc.edu
TEACHING FACULTY:
Wayne L. Backes, Ph.D. Professor of Pharmacology and Associate Dean for Research
Hamid Boulares, Ph.D., Associate Professor of Pharmacology
Andrew Catling, Ph.D., Associate Professor of Pharmacology
Charles Cefalu, M.D., Professor of Internal Medicine and Chief of Section of Geriatri Medicine
Stephania Cormier, Ph.D., Assistant Professor of Pharmacology
Bennet J. deBoisblanc, M.D., Professor of Medicine and Physiology, Director o Critical Care Services
Harry Gould, Ph.D., M.D., Professor of Neurology and Neuroscience
Paula Gregory, Ph.D., Associate Professor of Genetics
Deborah Fox, Ph.D., Assistant Professor of Pediatrics and Microbiology, Immunology and Parasitology
James Hill, Ph.D., Professor of Ophthalmology, Neuroscience, Pharmacology, and Microbiology
Jeffrey Hobden, Ph.D., Assistant Professor of Microbiology, Immunology, and Parasitology
Stephen Kantrow, M.D., Associate Professor of Medicine
Daniel R. Kapusta, Ph.D., Professor of Pharmacology
Alan Kaye, M.D., Ph.D., Chair and Professor of Anesthesiology, Professor of Pharmacology
Eric Lazartigues, Ph.D., Assistant Professor of Pharmacology
Kim E. LeBlanc, M.D., Ph.D., Chair and Professor of Family Medicine
Charles Nichols, Ph.D., Assistant Professor of Pharmacology
Dennis Paul, Ph.D., Associate Professor of Pharmacology
Robert Richards, M.D.,Associate Professor of Medicine, Co-Director, Diabetes Clinic
Reginald D. Sanders, M.D., Rheumatologist in Private Practice
Emel Songu-Mize, Ph.D., Professor of Pharmacology
Victor Tuckler, M.D., Clinical Instructor of Medicine
Kurt J. Varner, Ph.D., Interim Head and Professor of Pharmacology
Peter Winsauer, Ph.D., Professor of Pharmacology
Thomas Cooper Woods, Ph.D., Instructor, Department of Pharmacology, Head, Laboratory of Molecular Cardiology, Ochsner Clinic Foundation
Becky Worthylake, Ph.D., Assistant Professor of Pharmacology
Guangyu Wu, Ph.D., Associate Professor of Pharmacology
-------------
Department Office – MedicalEducationBuilding, Suite 7103, Phone 504-568-4740
Medical Pharmacology 2009
|
LECTURE AND EXAMINATION SCHEDULE |
||||||
|
|
|
|
|
|
|
|
|
All material in this syllabus is copyrighted and intended for LSUHSC personnel and students only. |
||||||
|
Any distribution otherwise is unlawful, and will result in prosecution. |
|
|
||||
|
|
|
|
|
|
|
|
|
DATE |
|
TIME |
|
SUBJECT |
|
INSTRUCTOR |
|
|
|
|
|
|
|
|
|
Jan |
5 |
10:00 |
|
Drug Receptor Mechanisms |
|
Paul |
|
|
|
11:00 |
|
Drug Receptor Mechanisms |
|
Paul |
|
|
|
|
|
|
|
|
|
Jan |
7 |
10:00 |
|
Absorption, Distribution & Excretion |
|
Wu |
|
|
|
11:00 |
|
Absorption, Distribution & Excretion |
|
Wu |
|
|
|
|
|
|
|
|
|
Jan |
8 |
8:00 |
|
Absorption, Distribution & Excretion |
|
Wu |
|
|
|
9:00 |
|
Drug Metabolism |
|
Backes |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jan |
12 |
10:00 |
|
Drug Metabolism (problem st answers) |
|
Backes |
|
|
|
11:00 |
|
Clinical Pharmacokinetics |
|
Backes |
|
|
|
|
|
|
|
|
|
Jan |
14 |
10:00 |
|
Clinical Pharmacokinetics |
|
Backes |
|
|
|
11:00 |
|
Clinical Pharmacokinetics |
|
Backes |
|
|
|
|
|
|
|
|
|
Jan |
15 |
8:00 |
|
Signal Transduction |
|
Catling |
|
|
|
9:00 |
|
Signal Transduction |
|
Catling |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jan |
19 |
|
|
MARTIN LUTHER KING DAY |
|
|
|
|
|
|
|
|
|
|
|
Jan |
21 |
10:00 |
|
Independent Study (test preparation) |
|
|
|
|
|
11:00 |
|
Introduction to Autonomics |
|
Kapusta |
|
|
|
|
|
|
|
|
|
Jan |
22 |
8:00 |
|
Parasympathetic Nervous System |
|
Kapusta |
|
|
|
9:00 |
|
Parasympathetic Nervous System |
|
Kapusta |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jan |
26 |
10:00 |
|
Sympathetic Nervous System |
|
Kapusta |
|
|
|
11:00 |
|
Sympathetic Nervous System |
|
Kapusta |
|
|
|
|
|
|
|
|
|
Jan |
28 |
10:00 |
|
Anticoagulants |
|
Woods |
|
|
|
11:00 |
|
Antianemics |
|
Woods |
|
|
|
|
|
|
|
|
|
Jan |
29 |
8:00 |
|
Diuretics |
|
Kapusta |
|
|
|
9:00 |
|
Diuretics |
|
Kapusta |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Feb |
2 |
10:00 |
|
Pharmacotherapy of Hypertension |
|
Songu-Mize |
|
|
|
11:00 |
|
Pharmacotherapy of Hypertension |
|
Songu-Mize |
|
|
|
|
|
|
|
|
|
Feb |
4 |
10:00 |
|
Antiarrhythmic Drugs |
|
Varner |
|
|
|
11:00 |
|
Antiarrhythmic Drugs |
|
Varner |
|
|
|
|
|
|
|
|
|
Feb |
5 |
8:00 |
|
Exam Review |
|
Faculty |
|
|
|
9:00 |
|
Autonomic Pharmacology Review and Problems |
|
Kapusta |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Feb |
9 |
9:00 |
|
EXAM I |
|
S-M, Kapusta |
|
|
|
10:00 |
|
EXAM I |
|
S-M, Kapusta |
|
|
|
|
|
|
|
|
|
Feb |
11 |
10:00 |
|
Pharmacotherapy of Congestive Heart Failure |
|
Varner |
|
|
|
11:00 |
|
Pharmacotherapy of Congestive Heart Failure |
|
Varner |
|
|
|
|
|
|
|
|
|
Feb |
12 |
8:00 |
|
Antianginal Agents - Notes |
|
Kapusta |
|
|
|
9:00 |
|
NSAIDS |
|
Boulares |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Feb |
16 |
10:00 |
|
NSAIDS |
|
Boulares |
|
|
|
11:00 |
|
Antiinflammatory Agents |
|
Paul |
|
|
|
|
|
|
|
|
|
Feb |
18 |
10:00 |
|
Antihistamine Agents |
|
Songu-Mize |
|
|
|
11:00 |
|
Antilipidemic Agents |
|
Boulares |
|
|
|
|
|
|
|
|
|
Feb |
19 |
8:00 |
|
Respiratory Drugs |
|
Cormier |
|
|
|
9:00 |
|
Clinical Correlation: Asthma |
|
deBoisblanc |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Feb |
23 |
|
|
MARDI GRAS |
|
|
|
|
|
|
|
|
|
|
|
Feb |
25 |
10:00 |
|
No Class |
|
|
|
|
|
11:00 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Feb |
26 |
8:00 |
|
Pharmacotherapy of Gastrointestinal Disease |
|
Nichols |
|
|
|
9:00 |
|
Pharmacotherapy of Gastrointestinal Disease |
|
Nichols |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mar |
2 |
10:00 |
|
Pharmacotheraphy of Gout and Arthritis |
|
Sanders |
|
|
|
11:00 |
|
Pharmacotheraphy of Gout and Arthritis |
|
Sanders |
|
|
|
|
|
|
|
|
|
Mar |
4 |
10:00 |
|
Hypoglycemic Agents |
|
Varner |
|
|
|
11:00 |
|
Clinical Correlation: Diabetes Mellitus |
|
Richards |
|
|
|
|
|
|
|
|
|
Mar |
5 |
8:00 |
|
Hypothalamic & Pituitary Hormones |
|
Lazartigues |
|
|
|
9:00 |
|
Hypothalamic & Pituitary Hormones |
|
Lazartigues |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mar |
9 |
10:00 |
|
Androgens, Estrogens & Progestins |
|
Worthylake |
|
|
|
11:00 |
|
Androgens, Estrogens & Progestins |
|
Worthylake |
|
|
|
|
|
|
|
|
|
Mar |
11 |
10:00 |
|
Thyroid Hormones |
|
Lazartigues |
|
|
|
11:00 |
|
Antifungal Drugs |
|
Fox |
|
|
|
|
|
|
|
|
|
Mar |
12 |
8:00 |
|
Antimicrobial Drugs, 2, 3, 4, PP1, PP2, PP3 and PP4 |
|
Hobden |
|
|
|
9:00 |
|
Exam Review |
|
Faculty |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mar |
16 |
9:00 |
|
EXAM II |
|
S-M, Kapusta |
|
|
|
10:00 |
|
EXAM II |
|
S-M, Kapusta |
|
|
|
|
|
|
|
|
|
Mar |
18 |
10:00 |
|
Antimicrobial Drugs |
|
Hobden |
|
|
|
11:00 |
|
Antimicrobial Drugs |
|
Hobden |
|
|
|
|
|
|
|
|
|
Mar |
19 |
8:00 |
|
Antiviral Agents |
|
Hill |
|
|
|
9:00 |
|
Antiviral Agents |
|
Hill |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mar |
23 |
10:00 |
|
Cancer Chemotherapy |
|
Catling |
|
|
|
11:00 |
|
Cancer Chemotherapy |
|
Catling |
|
|
|
|
|
|
|
|
|
Mar |
25 |
10:00 |
|
Immunosuppressant Drugs |
|
Kantrow |
|
|
|
11:00 |
|
Antiepileptic Drugs |
|
Nichols |
|
|
|
|
|
|
|
|
|
Mar |
26 |
8:00 |
|
Pharmacotherapy of Movement Disorders |
|
Winsauer |
|
|
|
9:00 |
|
Pharmacotherapy of Psychoses |
|
Winsauer |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mar |
30 |
10:00 |
|
Lithium & Antidepressant Drugs |
|
Winsauer |
|
|
|
11:00 |
|
Lithium & Antidepressant Drugs |
|
Winsauer |
|
|
|
|
|
|
|
|
|
April |
1 |
10:00 |
|
Alcohol, Anxiolytics & Sedative Hypnotics |
|
Winsauer |
|
|
|
11:00 |
|
Alcohol, Anxiolytics & Sedative Hypnotics |
|
Winsauer |
|
|
|
|
|
|
|
|
|
April |
2 |
8:00 |
|
CNS Stimulants |
|
Winsauer |
|
|
|
9:00 |
|
Pharmacogenomics |
|
Gregory |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
April |
6 |
10:00 |
|
Opioid Analgesics |
|
Paul |
|
|
|
11:00 |
|
Opioid Analgesics |
|
Paul |
|
|
|
|
|
|
|
|
|
April |
8 |
10:00 |
|
Pain Management |
|
Gould |
|
|
|
11:00 |
|
Pain Management |
|
Gould |
|
|
|
|
|
|
|
|
|
April |
9 |
8:00 |
|
Clinical Correlation: Headaches |
|
Gould |
|
|
|
9:00 |
|
Independent Study; Drug Regulation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
April |
13 |
|
|
SPRING HOLIDAY |
|
|
|
|
|
|
|
|
|
|
|
April |
15 |
10:00 |
|
Drugs of Abuse |
|
Winsauer |
|
|
|
11:00 |
|
Drugs of Abuse |
|
Winsauer |
|
|
|
|
|
|
|
|
|
April |
16 |
8:00 |
|
General Anesthetics |
|
Kaye |
|
|
|
9:00 |
|
Local Anesthetics |
|
Kaye |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
April |
20 |
10:00 |
|
Geriatric Medicine |
|
Cefalu |
|
|
|
11:00 |
|
Geriatric Medicine |
|
Cefalu |
|
|
|
|
|
|
|
|
|
April |
22 |
10:00 |
|
Integrative Pharmacology |
|
LeBlanc |
|
|
|
11:00 |
|
Ergogenic Supplements |
|
LeBlanc |
|
|
|
|
|
|
|
|
|
April |
23 |
8:00 |
|
Toxicology and Drug Overdose |
|
Tuckler |
|
|
|
9:00 |
|
Toxicology and Drug Overdose |
|
Tuckler |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
April 27-May 1 |
|
STUDY WEEK (Exam Review This week) |
|
|
||
|
|
|
|
|
|
|
|
|
May |
4 |
9:00 |
|
EXAM III |
|
S-M, Kapusta |
|
|
|
10:00 |
|
EXAM III |
|
S-M, Kapusta |
|
|
|
|
|
|
|
|
|
May |
8 |
9 -12:00 |
FINAL EXAM (Pharmacology Shelf) |
|
|
|
|
|
|
|
|
|
|
|
contact webmaster | disclaimer | privacy
policy
sign in
Copyright 2003-2008. All Rights Reserved.
Last Update: 4/7/2009