Hamid Boulares, PhD

Professor of Pharmacology

LSU Health Sciences Center
1901 Perdido Street P7-1
New Orleans, LA 70112
Phone: (504) 568-2304
Fax: (504) 568-2361




PhD - 1997
University of Connecticut, Storrs, CT

Research Interests Use of cell culture systems and animal models to study the intricate relation between poly(ADP) ribose polymerase1 (PARP-1)
Oxidative stress in asthma, atherosclerosis, and colon cancer
Selected Publications


Selected Recent Publications: 

· Boulares, A.H., Zoltoski, AJ., Sherif, Z., Jolly, p., Massaro, D., and Smulson, ME. Gene  knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma (2003). Am. J. Respir. Cell Mol. Biol. 28: 322-329.

· Boulares, A.H. and Ren, T (2004). Mechanism of acetaminophen-induced apoptosis in cultured cells: Roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3. Pharmacol. Toxicol. 94: 19-29.  

· Han S, Espinoza LA, Liao H, Boulares AH, Smulson ME. Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard analog 2-chloroethylethyl sulphide (CEES) in Jurkat T cells and normal human lymphocytes (2004). Br J Pharmacol. 141(5):795-802. 

· Oumouna M, Datta, R, Oumouna-Benachour, K., Suzuki, Y., Hans, C., Matthews, K., Fallon, K. and Boulares, H. PARP-1 Inhibition Prevents eosinophil recruitment by Modulating Th2 Cytokines in a Murine Model of Allergic Airway Inflammation: a Potential Specific Effect on IL-5. J. Immunol. (2006) 177(9):6489-96. 

· Oumouna-Benachour K, Hans, C, Suzuki, Y, Naura, A., Datta, R, Belmadani, S., Woods, C, and Boulares, H. PARP-1 Inhibition Reduces Atherosclerotic Plaque Size and Promotes Factors of Plaque Stability in ApoE-Deficient Mice: Effects on Macrophage Recruitment, NF-kB Nuclear Translocation, and Foam Cell Death. (2007)  Circulation 115 (18): 2442. 

·  Oumouna-Benachour, Karine, Mustapha Oumouna, Mourad Zerfaoui, Chetan Hans, Kenneth Fallon, and A. Hamid, Boulares. Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis (2007). Mol. Carcinog. 46(12):993-1002

·  Masayuki Kanai, Kazuhiko Hanashiro, Song-Hee Kim, Shuji Hanai, A. Hamid Boulares, Masanao Miwa, and Kenji Fukasawa. (2007).  Inhibition of Crm1-p53 Interaction and Nuclear Export of p53 by Poly(ADP-ribosyl)ation. Nature Cell Biol.9(10):1175-83 

· Amarjit S. Naura, Chetan P. Hans, Mourad Zerfaoui, Dahui You, Stephania A. Cormier, Mustapha Oumouna, and A. Hamid Boulares. (2008). Post-allergen Challenge Inhibition of Poly(ADP-ribose) Polymerase Harbors Therapeutic Potential for Treatment of Allergic Airway Inflammation. Clin. Exp. Allergy 38(5):839-46. 

· Mourad Zerfaoui, Yasuhiro Suzuki, Amarjit Naura, Chetan Hans, and A. Hamid Boulares. (2007). Nuclear translocation of p65 NF-kB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: differential requirement for PARP-1 expression and interaction (2008). Cellular Signalling 20(1):186-94. 

· Hans, PC., Zerfaoui, M., Naura, AS., Catling, A., and Boulares, AH. Differential Effects of PARP Inhibition on Vascular Cell Survival and ACAT-1 Expression Favoring Atherosclerotic Plaque Stability (2008). Cardiovascular Res. 78(3):429-39. 

· Belmadani S, Palen DI, Gonzalez-Villalobos RA, Boulares HA, Matrougui K. (2008). Elevated Epidermal Growth Factor Receptor Phosphorylation Induces Resistance Artery Dysfunction in Diabetic db/db mice.  Diabetes. 2008 57(6):1629-37

· S. Belmadani, M. Zerfaoui, AH. Boulares, D. I. Palen, K. Matrougui. (2008) Microvessels Vascular Smooth Muscle Cells Contribute to Collagen Type-I deposition Through ERK1/2 MAP-kinase, avb3-Integrin and TGFb1 in Response to Angiotensin II and High Glucose. Am J Physiol Heart Circ Physiol 295(1):H69-76  

· J. Su, P. Lucchesi, R. Gonzalez, D. I. Palen, B. M. Rezk, Y. Suzuki, AH. Boulares, K. Matrougui. (2008) Role of Advanced Glycation End Products with Oxidative Stress in Resistance Artery Dysfunction in Type 2 Diabetic mice.  Arterioscler Thromb Vasc Biol. 28(8):1432-8. 

· Naura A S, R Datta, C P. Hans, M Zerfaoui, Y Errami, B. M. Rezk, M Oumouna, K. Matrougui, and A H Boulares. (2008) Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia. Eur Respir. J (In Press). 

· Hans C P., M. Zerfaoui, A S. Naura, D Troxclair, JP. Strong, K Matrougui, and A. H. Boulares. (2008) Thieno[2,3-c]isoquinolin-5-one (TIQ-A), a potent PARP inhibitor, promotes atherosclerotic plaque regression in high fat diet-fed ApoE-deficient mice: effects on inflammatory markers and lipid content.  J Pharmacol Exp Ther. (In press)