Catalin Filipeanu, MD, PhD

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	Catalin Filipeanu, MD, PhD Assistant Research Professor CoBRE Junior Investigator Department of Pharmacology and Experimental Therapeutics Cardiovascular Center of Excellence LSUHSC – MedicalEducationBuilding, Room 5201, 1901 Perdido Street, New Orleans, LA 70112 Phone: (504) 568 4514 Fax: (504) 568 2361 Email: cfilip@lsuhsc.edu
Degrees	M.D. – 1996, University of Medicine “Gr. T. Popa”, Iasi, Romania Ph.D. – 2001, Rijksuniversiteit Groningen, The Netherlands Thesis: “Intracellular angiotensin: from myth to reality.”
Bio	Catalin Filipeanu become interested in cell physiology while being a medical student and he started working in the Dr. Branisteanu”s lab. After obtaining his MD in 1996, he was awarded the “Ubbo Emmius” fellowship from Dutch Ministry of Foreign Affairs and attended Rijksuniversiteit Groningen, where in 2001 he obtained his Ph.D. in Molecular Pharmacology. The subject of his thesis was on the intracellular effects of angiotensin II. From 2001 to 2003, he worked as a Postdoctoral Fellow with Dr. Nae Dun on the central and peripheral effects of urotensin II. In 2004, he moved to the Department of Pharmacology at LSUHSC-NO where he continued his postdoctoral training with Dr. Guangyu Wu studying the regulation of intracellular protein transport. In November 2007, he was promoted to his first faculty position, as Research Assistant Professor in the Department of Pharmacology and Experimental Therapeutics, LSUHSC.
Research Interests	My primary project concentrates on the elucidation of the pathologic mechanisms involved in Raynaud Phenomenon. Cold-induced constriction of peripheric arteries is a normal response contributing to preservation of body temperature. In some individuals this response is exaggerated and leads to painful discoloration of the fingers, toes and other extremities. These are manifestations of Raynaud Phenomenon. Experimental evidence supports a role of α_2C-adrenergic receptors in these symptoms. At 37^oC, α_2C-AR is poorly transported to the cell surface and accumulates inside the cell. Exposure to low temperature is enhancing its transport to the plasma membrane and increases the vasoconstrictor response to circulating cathecolamines. Currently, using molecular and cell biology approaches, we are characterizing the mechanisms limiting the α_2C-AR transport to the cell surface. Other current projects in the lab are focusing on understanding the role of molecular chaperones in the receptor trafficking, transport to the cell surface and signaling modulation.
Selected Publications	Filipeanu CM, Zhou F, Lam ML, Kerut KE, Claycomb WC, Wu G. Enhancement of the recycling and activation of beta-adrenergic receptor by Rab4 GTPase in cardiac myocytes. J Biol Chem. 2006; 281(16):11097-103 Filipeanu CM, Zhou F, Claycomb WC, Wu G. Regulation of the cell surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes. J Biol Chem. 2004; 279(39):41077-84. Filipeanu CM, Brailoiu E, Le Dun S, Dun NJ.Urotensin-II regulates intracellular calcium in dissociated rat spinal cord neurons. J Neurochem. 2002; 83(4):879-84. Filipeanu CM, Henning RH, de Zeeuw D, Nelemans A.Intracellular Angiotensin II and cell growth of vascular smooth muscle cells. Br J Pharmacol. 2001; 132(7):1590-6.

Assistant Research Professor CoBRE Junior Investigator

Assistant Research Professor

CoBRE Junior Investigator