LSU Health New Orleans

Departments & Centers | Contact | Donate

Administration Basic Sciences Clinical Sciences Centers of Excellence
Lazartigues Lab Home (Click on the mouse)
Important links


ncar main











Cover figures from the lab

Breeding strategy to generate triple transgenic SARA mice overexpressing human angiotensionogen, renin and angiotensin converting enzyme type 2 in the central nervous system; bottom left: immunostaining for the Mas receptor in the paraventricular nucleus of a syn-hACE2 transgenic mouse overexpressing human ACE2 specifically in neurons; bottom right: spontaneous baroreflex sensitivity in wildtype (left), chronically hypertensive R+A+ double transgenic mice (middle) and triple transgenic SARA mice (right).

The colocalization of the human Angiotensin Converting Enzyme type 2 (ACE2; red) and mouse Microtubule-Associated Protein-2 (MAP2; green), a marker for neurons and 4”,6-diamidino-2-phenylindole (DAPI; blue), a nucleic acid marker, in the syn-hACE2 transgenic mouse rostral ventrolateral medulla (RVLM) detected by immunofluorescence. Overlapping fluorescence (yellow) indicates that the human ACE2 transgene expression is specifically targeted to neurons. Magnification: 60X.

Human angiotensin-converting enzyme 2 (hACE2) expression in neurons of rostral ventrolateral medulla (RVLM) in triple transgenic model (SARA) mice. A, Immunostaining for hACE2 (red), microtubule associated protein-2 (MAP-2; neuronal marker, green), and 4′,6-diamidino-2-phenylindole (DAPI; nucleic acid marker, blue) in the RVLM of a SARA mouse (magnification ×10). B, Increased magnification (×40) shows the presence of hACE2 in cells of the RVLM. C, MAP-2 immunofluorescence shows the distribution of neurons in the RVLM (×40). D, Overlapping fluorescence (yellow) confirms the presence of hACE2 on neurons in the RVLM (×40).


Lazartigues’ Laboratory
2015 9:58:36 AM

“From Gene to Function: the Role of the Renin-Angiotensin System in the Regulation of Cardiovascular Function ”.


News from the Lab: 

Experimental Biology,  Chicago, IL, USA, April 22-26th 2017:


Experimental Biology, San Diego, CA, USA, April 2-6th 2016:

Angiotensin Gordon Research Conference, Il Ciocco, Italy, February 21-26th 2016:

  • Dr. Jiaxi Xu made an oral presentation entitled “ADAM17 in Neurogenic Hypertension: Function and Regulation”. Dr. Xu received the Gordon Research Conference Poster Award.

X International Symposium on Vasoactive Peptides, Lagoa dos Ingleses, Minas Gerais, Brazil, October 29-31st 2015:

  • Ms. Snigdha Mukerjee made an oral presentation entitled “ACE2 modulates the excitability of pre-sympathetic neurons in the paraventricular nucleus”.


  • Dr. Jiaxi Xu was awarded a 2-year Post-doctoral fellowship from the American Heart Association Greater SouthEast Affiliate to study the role of ADAM17 and AT1 receptors in neurogenic hypertension (July 2015).
  • Dr. Srinivas Sriramula was awarded a 3-year Scientist Development Grant from the American Heart Association Greater SouthEast Affiliate to study the role of bradykinin receptors in neurogenic hypertension (July 2015).





website counter
Stats For Free