Charles D. Nichols, PhD

Associate Professor of Pharmacology

1901 Perdido Street
New Orleans, LA 70112
Phone: (504) 568-2957
cnich1@lsuhsc.edu

Lab Page

BS Biology/Biochemistry - 1989
Purdue University, West Lafayette, IN

PhD Biological Sciences - 1997
Carnegie Mellon University, Pittsburgh, PA

Pharmacology Postdoctoral Fellow - 1997-2002
Vanderbilt University, Nashville, TN

Serotonin receptor pharmacology in Drosophila and mammalian systems

Published

Dong, C., C.D. Nichols, Guo, J., Huang, W., Lambert, N.A., and G. Wu (2012). A Triple Arg Motif Mediates ?2B-Adrenergic Receptor Interaction with Sec24C/D and Export. Traffic. In Press.

Nichols, C.D., and U.B.Pandey (2012). Methods to assay Drosophila behavior. JoVE. Mar 7; (61).

Luo, J., Becnel, J., Nichols, C.D., Nässel, D.R. (2012) Insulin producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor during stress. Cell and Molecular Life Sciences. 2012 Feb;69(3):471-84.

Johnson, O, J. Becnel, and C.D. Nichols (2011). Serotonin receptor activity is required for normal learning and memory in Drosophila melanogaster. Neuroscience.

Becnel, J., O. Johnson, J. Luo, D. Nässel, and C.D. Nichols (2011). The serotonin
5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating. PLoS One. 6(6): e20800.

Pandey, U.B., and C.D. Nichols (2011). Human disease models in Drosophila melanogaster,  and the role of the fly in therapeutic drug discovery. Pharm Rev. 63(2):411-436.

Maronica-Lewica, D., C.D. Nichols, and D.E. Nichols (2011). An animal model of schizophrenia based on chronic LSD administration: Old idea, new results. Neuropharmacology. 61:503-512.

Nichols C.D. (2009). Serotonin 5-HT_2A receptor function as an underlying factor contributing to both cardiovascular and psychiatric disease. Cardiovasc Psychiatry Neurol. 2009:475108

Nichols C.D. and B.L. Roth (2009). Engineered G-protein coupled receptors as a tool to investigate biological processes. Front Mol Neurosci. 2:16

Johnson, O. J. Becnel, and C.D. Nichols (2009). Serotonin 5-HT_1A and 5-HT₂ receptors modulate different aspects of aggressive behaviors in Drosophila. Neuroscience. 4:1292-1300.

Duvernay M.T., Dong C., Zhang X., Zhou F., Nichols C.D., G. Wu (2009). Anterograde trafficking of G protein-coupled receptors: function of the C-terminal F(X)6LL motif in export from the endoplasmic reticulum. Molecular Pharmacology. 75:751-61.

Yu, B.,  J. Becnel, M. Zerfaoui, R. Rohatgi, H. Boulares, C. D. Nichols (2008) Serotonin 5-HT_2A receptor activation suppresses TNF-a-induced inflammation with extraordinary potency. Journal of Pharmacology and Experimental Therapeutics. 327(2):316-23. *Featured article with commentary*

Nichols, D.E. and C.D. Nichols (2008). Serotonin Receptors. Chemical Reviews. 108(5):1614-1641.

Zerfaoui, M., Y. Suzuki, A.S. Naura, C.P.Hans, C.D. Nichols, A.H. Boulares (2008). Nuclear translocation of p65 NF-kB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction. Cellular Signaling, 20:186-194.

Nichols, C.D. (2007). 5HT₂ receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors. Developmental Neurobiology. 67:752-763.
Marvanova, M, and C.D. Nichols. (2007). Identification of neuroprotective compounds of C. elegans dopaminergic neurons against 6-OHDA. Journal of Molecular Neurobiology. 31:131-141.

Johnson, O, J. Becnel, and C.D. Nichols (2011). Serotonin receptor activity is required for normal learning and memory in Drosophila melanogaster. Neuroscience. 

Nichols, C.D. (2006). Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform CNS drug discovery. 2006. Pharmacology and Therapeutics. 112(3):677-700.

Behan, K.J., Fair, J., Sing, S., Bogwitz, M., Perry, T., Grubor, V., Cunningham, F., Nichols, C.D., Cheung, T., Batterham, P., and J.A. Pollock. (2005). Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development. Development Genes and Evolution. 215(8):423-35.

Nichols, C.D., and E. Sanders-Bush (2004). Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP Kinase Phosphatase-1, C/EBP-, and ILAD-1, a novel gene with homology to arrestins. Journal of Neurochemistry, Aug;90(3):576-84.

Nichols, C.D., E.E. Garcia, and E. Sanders-Bush (2003). Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration. Molecular Brain Research, 111: 182-188.

Nichols, C.D., J. Ronesi, W. Pratt, and E. Sanders-Bush (2002). Hallucinogens and Drosophila: Linking serotonin receptor activation to behavior. Neuroscience, 115: 979-984.

Nichols, C.D. and E. Sanders-Bush 2002). A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain. Neuropsychopharmacology, 26(5): 634-42.

Behan, K. J., C.D. Nichols, T. Cheung,  J. Fair, B. Hogan, P. Batterham,  and J. A. Pollock (2002). Yan regulates Lozenge through an eye specific enhancer in Drosophila. Development Genes and Evolution, 212:267–276.

É. L. S Loreto, A. Zaha, C. Nichols, J. A. Pollock, and V. L. S. Valente (1998). Characterization of a hypermutable strain of Drosophila simulans.CMLS, Cell and Molecular Life Sciences. 54: pp 1283-1290.

Pollock, J.A., A. Assaf, A. Peretz, C.D. Nichols, M.H. Mojet, R.C. Hardie, and B. Minke (1995).  TRP, a Protein Essential for Inositide-Mediated Ca²⁺ Influx Is Localized Adjacent to the Calcium Stores in Drosophila Photoreceptors. Journal of Neuroscience, 15(5):3747-3760.