Srinivas Sriramula, PhD

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Srinivas Sriramula




Lab Number

MEB 5219


(504) 568-3211


B.V.Sc. & A.H., M.V.Sc., PhD


PhD in Veterinary Medical Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.

Master of Veterinary Science (MVSc), College of Veterinary Science, A.N.G.R. Agricultural University, Hyderabad, India.

Research interests

1. Investigating the role of bradykinin 1 receptor in neurogenic hypertension.

2. Investigating the signaling pathways of angiotensin converting enzyme 2 (ACE2) in the central regulation of blood pressure.

Research Support

American Heart Association Scientist Development Grant

07/01/2015 – 06/30/2018

“Role of bradykinin 1 receptor in neurogenic hypertension”


  1. Sriramula S*, Joseph Francis*. Tumor necrosis factor – alpha is essential for angiotensin II-induced ventricular remodeling: Role for oxidative stress. PLoS ONE.2015, 10(9):e0138372 (*Corresponding author).
  2. Sriramula S, Xia H, Xu P, Lazartigues E. Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. Hypertension. 2015, 65(3):577-86.
  3. Xia H, Moreira de Queiroz T, Sriramula S, Feng Y, Johnson T, Mungrue IN, Lazartigues E. Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. American Journal of Physiology Regulatory Integrative and Comparative Physiology.2015, 308(5)R370-8.
  4. Deshotels MR, Xia H, Sriramula S, Lazartigues E, Filipeanu CM. Angiotensin II mediates Angiotensin Converting Enzyme 2 internalization and degradation through an Angiotensin II type 1 receptor-dependent mechanism. Hypertension. 2014, 64(6):1368-75.
  5. Xia H*, Sriramula S*, Kavaljit H, Lazartigues E. Brain ACE2 shedding contributes to the development of neurogenic hypertension.Circulation Research2013, 113:1087-1096. (*Equal first authors)
  6. Sriramula S, Cardinale JP, Francis J. Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension. PLoS ONE2013, 8(5):e63847.
  7. Cardinale JP, Sriramula S, Mariappan N, Agarwal D, Francis J. Angiotensin II-induced hypertension is modulated by Nuclear factor-kappa B in the paraventricular nucleus. Hypertension 2012, 59(1):113-121.
  8. Sriramula S, Cardinale JP, Lazartigues E, Francis J. ACE2 overexpression in the paraventricular nucleus attenuates angiotensin Ii-induced hypertension. Cardiovascular Research 2011, 92:401-8. (Editorial Comment by Olaf Grisk, Cardiovascular Research 2011, 92:365-366)
  9. Pedersen KB, Sriramula S, Chhabra KH, Xia H, Lazartigues E. Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays. American Journal of Physiology Regulatory Integrative and Comparative Physiology 2011, 301:R1293-9.
  10. Xu P, Sriramula S, Lazartigues E. ACE2/Ang-(1-7)/Mas pathway in the brain: The axis of good. American Journal of Physiology Regulatory Integrative and Comparative Physiology 2011, 300:R804-R817.
  11. Guggilam A, Cardinale JP, Mariappan N, Sriramula S, Haque M, Francis J. Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide.Basic Research in Cardiology 2011, 106:273-286.
  12. Cardinale JP, Sriramula S, Pariaut R, Guggilam A, Mariappan N, Elks C, Francis J. HDAC inhibition attenuates inflammatory, hypertrophic and hypertensive responses in spontaneously hypertensive rats. Hypertension 2010, 56:437-444.
  13. Shenoy V, Ferreira AJ, Qi Y, Fraga-Silva RA, Díez-Freire C, Dooies A, Jun JY, Sriramula S, Mariappan N, Pourang D, Venugopal CS, Francis J, Reudelhuber T, Santos RA, Patel JM, Raizada MK, Katovich MJ. The ACE2/Ang-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine2010, 182:1065-1072.
  14. Shi P, Diez-Freire C, Jun JY, Qi Y, Katovich MJ, Li Q, Sriramula S, Francis J, Sumners C, Raizada MK. Brain microglial cytokines in neurogenic hypertension. Hypertension2010, 56(2):297-303.
  15. Mariappan M, Elks CM, Sriramula S, Guggilam A, Liu Z, Borkhsenious O, Francis J. NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovascular Research2010, 85(3):473-83.
  16. Agarwal D, Haque M, Sriramula S, Mariappan N, Pariaut R, Francis J. Role of proinflammatory cytokines and redox homeostasis in exercise-induced delayed progression of hypertension in spontaneously hypertensive rats. Hypertension2009, 54(6):1393-400.
  17. Yamazato Y, Ferreira AJ, Hong KH, Sriramula S, Francis J, Yamazato M, Yuan L, Bradford CN, Shenoy V, Oh SP, Katovich MJ, Raizada MK. Prevention of pulmonary hypertension by Angiotensin converting enzyme 2 gene transfer. Hypertension2009, 54(2):365-71.
  18. Ferriera AJ, Shenoy V, Yamazato Y, Sriramula S, Francis J, Yuan L, Castellano RK, Ostrov DA, Paul Oh S, Katovich MJ, Raizada MK. Evidence for angiotensin converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine2009, 179(11):1048-54.
  19. Kang YM, Ma Y, Zheng JP, Elks C, Sriramula S, Yang ZM, Francis J. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research2009, 82(3):503-12.
  20. Sriramula S, Haque M, Majid DS, Francis J. Involvement of Tumor Necrosis Factor-alpha in Angiotensin II-Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy. Hypertension2008, 51(5):1345-1351.
  21. Mariappan N, Soorappan RN, Haque M, Sriramula S, Francis J. TNF-alpha induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic tempol. American Journal of Physiology Heart and Circulatory Physiology2007, 293(5):H2726-37.
  22. Sriramula Srinivas, Narasimharao G, Ahmed N and Gupta B R. Molecular genetic characterization of Ongole and Deoni cattle breeds using microsatellite markers. Indian Journal of Animal Sciences 2006, 76 (8), 649-652.
  23. Rao KR, Ahmed N, Sriramula Srinivas, Sechi LA, Hasnain SE. Rapid identification of Mycobacterium tuberculosis Beijing genotypes on the basis of the mycobacterial interspersed repetitive unit locus 26 signature. Journal of Clinical Microbiology 2006, 44(1):274-7.
  24. Rao KR, Kauser F, Sriramula Srinivas, Zanetti S, Sechi LA, Ahmed N, Hasnain SE. Analysis of genomic downsizing on the basis of region-of-difference polymorphism profiling of Mycobacterium tuberculosis patient isolates reveals geographic partitioning. Journal of Clinical Microbiology2005, 43(12):5978-82.
  25. Kauser F, Hussain MA, Ahmed I, Sriramula Srinivas, Devi SM, Majeed AA, Rao KR, Khan AA, Sechi LA, Ahmed N. Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England. BMC Microbiology2005, 5(1):32.


2011    New Investigator Travel Award from the American Heart Association for 2011 High Blood Pressure Research Conference

2012    Research Recognition Award from The American Physiological Society Central Nervous System Section

2012    Selected for Caroline tum Suden/Francis A. Hellebrandt Professional opportunity Award from The American Physiological Society

2012    New Investigator Travel Award for Trainees from the American Heart Association for 2012 High Blood Pressure Research Conference

2013    Neural Control and Autonomic Regulation Section Postdoctoral and Early Career Research Recognition Award from The American Physiological Society

2013    Postdoctoral Fellowship from the American Heart Association Greater Southeast Affiliate (2013-2015)

2014    American Physiological Society Cardiovascular Section Research Recognition Award

2014    Federation of American Societies for Experimental Biology (FASEB)/Maximizing Access to Research Careers (MARC) Grantsmanship Training Program Travel Award

2015    American Physiological Society Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award