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Simon, Liz, MVSc., Ph.D.

Assistant Professor

1901 Perdido Street 
New Orleans, LA 70112
Room 7249
(504) 568-3395
Email: lsimo2@lsuhsc.edu

Degrees

BVSc - Bachelor of Veterinary Sciences 1997, College of Veterinary and Animal Sciences, Kerala, India

MVSc - Master of Veterinary Sciences (Reproductive physiology) 1999, College of Veterinary and Animal Sciences, Kerala, India

Ph.D. – Reproductive physiology 2005, Tamilnadu Veterinary and Animal Sciences University, India

Bio

Dr. Simon received her Ph.D. in endocrine physiology with the support of an Indian Council of Agricultural Research fellowship and did her postdoctoral training at the College of Veterinary Medicine, University of Illinois at Urbana Champaign in stem cell/endocrine physiology. She was an Assistant Professor in the Department of Biomedical Sciences at the College of Veterinary Medicine, Tuskegee University from 2010-2013. She also held an adjunct faculty position, Department of Pathology, School of Medicine at the University of Alabama at Birmingham from 2012-2013. She joined the Department of Physiology at LSUHSC, NO in July 2013.

Research Interests

Dr. Simon’s research interests are to understand the signaling mechanisms responsible for proliferation and differentiation of stem/progenitor cells and perturbations that alter stem cells and its microenvironment affecting the fate of cells.

The laboratory is specifically interested in dysregulation of skeletal muscle stem cell (satellite cells) signaling that alters the fate of these cells. Using a model of chronic alcohol and Simian Immunodeficiency Virus (SIV) infection, Dr. Simon is studying the molecular mechanisms of impaired differentiation of satellite cells. Currently two mechanisms are being investigated. 1. Does a chronic proinflammatory and prooxidative skeletal muscle milieu inhibit myogenesis. 2. Does an altered skeletal muscle milieu induce epigenetic alterations in satellite cells leading to impaired myogenesis?

The research is in collaboration with eminent LSUHSC researchers in the field of alcohol and SIV

Teaching Activities

Endocrine physiology (Biological Systems Graduate Course)

Selected Publications
  1. Simon L, Hollenbach AD, Zabaleta J and Molina PE. (2015) Chronic binge alcohol administration dysregulates global regulatory gene networks associated with skeletal muscle wasting in simian immunodeficiency virus-infected macaques. BMC Genomics Dec 23;16(1):1097 PMID: 26699868
  2. Simon L, Song K, Stouwe CV, Hollenbach A, Amedee A, Mohan M, Winsauer P, Molina PE (2015) Δ9-tetrahydrocannabinol (Δ9-THC) promotes neuroimmune-modulatory microRNA profile in striatum of simian immunodeficiency virus (SIV)-infected macaques. J Neuroimmune Pharmacology PMID: 26607731
  3. Simon L, LeCapitaine N, Berner P, Stouwe CV Mussell JC, Allerton TD, Primeaux SD, Dufour J, Nelson S, Bagby GJ, Cefalu W and Molina PE (2014) Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques. American Journal of Physiology – Regulatory, Comparative and Integrative Physiology, March 26, 2014. PMID 24671243
  4. Molina PE, Amedee AM, Winsauer P, Nelson S, Bagby G, Simon L. (2015). Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model. J Neuroimmune Pharmacology. 2015 Mar 21. PMID:25795088
  5. Cooke PS, Simon L, Nanjappa MK, Medrano TI, Berry SE. (2015) Plasticity of spermatogonial stem cells. Asian J Androl. May-Jun;17(3):355-9 PMID:25677134
  6. Napier ID, Simon L, Perry D, Cooke PS, Stocco DM, Sepehr E, Doerge DR, Kemppainen BW, Morrison EE, Akingbemi BT (2014) Testicular Development in Male Rats Is Sensitive to a Soy-Based Diet in the Neonatal Period. Biology of Reproduction Feb 27;90(2):40. PMID 24451983
  7. Simon L, Cooke PS, Berry SE (2013) Aorta-Derived Mesoangioblasts Can Be Differentiated into Functional Uterine Epithelium, but Not Prostatic Epithelium or Epidermis, by Instructive Mesenchymes. Cells Tissues Organs 198(3):169-78. Epub 2013 Oct 26. PMID: 24192012
  8. Nanjappa MK, Simon L, Akingbemi BT (2012). The industrial chemical Bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat Leydig cells. Biology of Reproduction 86:1-12. PMID: 22302688.
  9. Simon L, Ekman GC, Garcia T, Carnes K, Zhang Z, Murphy T, Murphy KM, Hess RA, Cooke PS, Hofmann MC (2010). ETV5 regulates Sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells 28:1882-92. PMID: 20799334. PMC3109872
  10. Simon L, Hess RA, Cooke PS (2010). Spermatogonial stem cells, in vivo transdifferentiation and human regenerative medicine. Expert Opinion on Biological Therapy 10:519-30. PMID: 20146635
  11. Simon L, Ekman GC, Kostereva N, Zhang Z, Hess R, Hofmann MC and Cooke PS (2009). Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and non-reproductive tissues of all germ layers. Stem Cells 27:1666-75. PMID: 19544441.
  12. Simon L, Ekman GC, Tyagi G, Hess RA, Murphy KM, Cooke PS (2007). Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance. Experimental Cell Research 313: 3090-99. PMID:17574550

 

Additional Info

Curriculum Vitae