Robert W Siggins II,  Ph.D.

Assistant Professor of Physiology
Comprehensive Alcohol Research Center

1901 Perdido Street
New Orleans, LA 70112
Phone: (504) 568-7879
rsiggi@lsuhsc.edu

Degrees

B.S.   - 1999
B.A.  - 1999
      University of Southern Mississippi

Ph.D.   - 2006  - Physiology
      Louisiana State University Health Sciences Center

BioDr. Siggins completed his PhD training at the Louisiana State University Health Sciences Center in New Orleans. Thereafter, he pursued a Postdoctoral Fellowship at the New York Medical College studying cardiac stem cells (CSCs) and their ability to repair damaged myocardium. Following this training, Robert returned to LSU Health Sciences Center where he studied the effects of chronic and acute alcohol intoxication on bone marrow hematopoietic stem and progenitor cells. Following three years of service, Robert submitted a K99/R00 to the NIAAA to study the effects of chronic alcohol administration on myeloid dendropoiesis and osteoclastogenesis from a common upstream progenitor in bone marrow from rhesus macaques.
Research Interests

• Impact of chronic alcohol consumption on the disruption of bone marrow progenitor cell differentiation
• Effects of acute alcohol intoxication on the bone marrow response to bacteremia
• Understanding the role of ethanol in dysregulating DNA methylation patterns, and the physiologic outcome of these perturbations

Teaching ActivitiesDr. Siggins has taught several lectures in a variety of graduate and nursing courses including “Alcohol, Wnt Signaling, and Dendropoiesis”, “Real-time PCR”, “Stem Cells and the Cardiovascular System: From Embryo to Adult”, “Altitude and Hematopoiesis”, “Membranes and Compartments”, “Transmembrane Potential”, and “Proteins and Mediated Transport”. In addition, he will be co-directing the Department of Physiology Seminar Series, as well as assisting the course director for Nursing Pathophysiology.
Selected PublicationsBearzi, C., Rota, M., Hosoda, T., Tillmanns, J., Nascimbene, A., DeAngelis, A.,Yasuzawa-Amano, S., Trofimova, I., Siggins, R.W., LeCapitaine, N., Cascapera, S., Beltrami, A.P., D’Alessandro, D.A., Zias, E.,Quaini, F., Urbanek, K., Michler, R.E., Bolli, R., Kajstura, J., Leri, A., and Anversa, P. Human Cardiac Stem Cells. Proceedings of the National Academy of Sciences, 2007; 104(35): 14068-14073.

Tillmanns, J., Rota, M., Hosoda, T., Misao, Y., Esposito, G., Gonzalez, A., Vitale, S., Parolin, C., Yasuzawa-Amano, S., Muraski, J., De Angelis, A., LeCapitaine, N., Siggins, R.W., Loredo, M., Bearzi, C., Bolli, R., Urbanek, K., Leri, A., Kajstura, J., and Anversa, P. Formation of Large Coronary Arteries by Cardiac Progenitor Cells. Proceedings of the National Academy of Sciences, 2008; 105(5):1668-1673.

Siggins, R.W., Zhang, P., Welsh, D.A., LeCapitaine, N.J., and Nelson, S. Stem Cells, Phenotypic Inversion, and Differentiation. International Journal of Clinical and Experimental Medicine. 2008; 1(1): 2-21.

Zhang, P., Nelson, S., Bagby, G.J., Siggins, R.W., Shellito, J.E., and Welsh, D.A. Lineage-c-kit+Sca-1+ Cell Response to Escherichia Coli Bacteremia in Balb/c Mice. Stem Cells. 2008; 26(7):1778-1786.

Zhang, P., Welsh, D.A., Siggins, R.W., Bagby, G.J., Raasch, C.E., Happel, K.I., and Nelson, S. Acute Alcohol Intoxication Inhibits the Lineage-c-kit+Sca-1+ Cell Response to Escherichia Coli Bacteremia. Journal of Immunology. 2009; 182(3)1568-1576.

Siggins, R.W., Bagby, G.J., Molina, P.E., Dufour, J., Nelson, S., and Zhang, P. Alcohol Exposure Impairs Myeloid Dendritic Cell Function in Rhesus Macaques. Alcoholism: Clinical and Experimental Research. 2009; 33(9):1524-1531.

Raasch, C.E., Zhang, P., Siggins, R.W., LaMotte, L., Bagby, G.J., and Nelson, S. Acute Alcohol Intoxication Impairs the Hematopoietic Precursor Cell Response to Pneumococcal Pneumonia. Alcoholism: Clinical and Experimental Research. 2010; 34(12):2035-2043.

Additional Info

Curriculum Vitae

Center of Excellence

Member of the Alcohol and Drug Abuse Center of Excellence