FACULTY
Academic Office:
LSUHSC School of Medicine
533 Bolivar Street, Box CSRB 3-42
New Orleans, LA 70112
Bio
The Sharp laboratory is focused on the develop and translational application of novel therapeutic strategies to combat cardiovascular diseases. Specifically, utilizing clinical biobanked specimens, in vivo small and large animal models to recapitulate clinical pathophysiology in order to gain insight into novel mechanism which drive disease. With this knowledge, my laboratory then investigates innovative and novel therapeutic strategies to alter the development, manifestation and progression of cardiovascular diseases. Areas of interest include cardioprotection, post myocardial infarction remodeling and the restoration or preservation of cardiovascular function in the setting of heart failure with an emphasis on heart failure with preserved ejection fraction. My laboratory is also interested in factors which mediate changes in the gut microbiome and metabolome leading to changes in the host metabolome and cardiovascular system. The primary goal of my laboratory is to investigate and assess novel therapeutic strategies and their translational application towards altering cardiovascular disease states. It is my hope that this research will lead to novel and clinically meaningful interventions for patients who suffer with cardiovascular disease and ultimately impact human health. .
Education
Undergraduate:
2010 - B.A. in Neuroscience
Drew University
Madison, New Jersey
Doctorate:
2017 - Doctorate of Philosophy, Molecular and Cellular Physiology
Temple University Lewis Katz School of Medicine
Philadephia, Pennsylvania
Fellowship:
2020 - Cardiovascular Pathophysiology
Louisiana State University School of Medicine, Cardiovascular Center of Excellence
New Orleans, Louisiana
Publications
1. Sharp TE, Lefer DJ. Renal Denervation to Treat Heart Failure. Annual Review of Physiology. 2021; 83.
2. Sharp TE, Scarborough AL, Li Z, Polhemus DJ, Hidalgo HA, Schumacher JD, Matsuura TR, Jenkins JS, Kelly DP, Goodchild TT, Lefer DJ. Novel Gottingen miniswine model of heart failure with preserved ejection fraction integrating multiple comorbidities. JACC: Basic to Translational Science. 2021;6:154-170
3. Sharp TE, Gong Z, Scarborough A, Goetzman ES, Ali MJ, Spaletra P, Lefer DJ, Muzumdar RH, Goodchild TT. Efficacy of a novel mitochondrial-derived peptide in a porcine model of myocardial ischemia/reperfusion injury. JACC: Basic to Translational Science. 2020:466
4. Organ CL, Li Z, Sharp TE, Polhemus DJ, Gupta N, Goodchild TT, Tang WHW, Hazen SL, Lefer DJ. Nonlethal inhibition of gut microbial trimethylamine n-oxide production improves cardiac function and remodeling in a murine model of heart failure. Journal of the American Heart Association. 2020; 9: e016223
5. Polhemus DJ, Trivedi RK, Sharp TE, Li Z, Goodchild TT, Scarborough A, de Couto G, Marbán E, Lefer DJ. Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: Exploring modalities for improving cell therapy efficacy. Basic Research in Cardiology. 2019;114:9
6. Sharp TE, Polhemus DJ, Li Z, Spaletra P, Jenkins JS, Reilly JP, White CJ, Kapusta DR, Lefer DJ, Goodchild TT. Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system. Journal of the American College of Cardiology. 2018;72:2609
7. Sharp TE, Schena GJ, Hobby AR, Starosta T, Berretta RM, Wallner M, Borghetti G, Gross P, Yu D, Johnson J, Feldsott E, Trappanese DM, Toib A, Rabinowitz JE, George JC, Kubo H, Mohsin S, Houser SR. Cortical bone stem cell therapy preserves cardiac structure and function after myocardial infarction. Circulation Research. 2017;121:1263-1278
Research
Title: Cortical Bone Stem Cells to Repair the Post MI Heart
Sponsor: AHA, Predoctoral Fellowship
Role: Primary Investigator
Dates: 2014
Title: Combined Cell Therapy and Renal Denervation to Prevent Heart Failure after Myocardial
Infarction
Sponsor: AHA, Predoctoral Fellowship
Role: Primary Investigator
Dates: 2018
Title: Cardioprotective Effects of RDN on Left Ventricular Remodeling Following Acute Myocardial
Infarction
Location: ReCor Medical, Extramural
Role: Co-Investigator
Dates: 2020
Title: Renal Denervation in Heart Failure with Preserved Ejection Fraction”
Location: NIH/NHLBI (R01)
Role: Co-Investigator
Dates: 2021
Title: Alcohol-induced Gut Dysbiosis and Cardiovascular Disease
Location: NIH/NHLBI (R01)
Role: Primary Investigator
Dates: Pending 2022