Jean T. Jacob , Ph.D.
Emeritus Professor of Ophthalmology and Neuroscience
LSU Eye Center
LSU Eye Center
ELAM, Executive Leadership in Academic Medicine Program
B.S., Biochemistry University of California at Riverside
Biocompatibility of Contact Lenses
Dry Eye Tear Film Characteristics
Drug Delivery Devices
Biocompatibility of synthetic and bio-polymers in the ocular environment. This involves analyzing the polymer surface and the adjacent tissue on a submicroscopic level for chemical changes in the polymer, deposition of protein and cofactors onto the polymer, chemical changes in the extracellular matrix adjacent to the polymer surface, and quantitative differences in the composition in the adjacent tissue (for example, number of macrophages, types of collagen present).
Dr. Jacob has directed the biomaterials research activities of over 76 resident, medical, graduate, and undergraduate students in all areas of ophthalmic devices and drug delivery systems.
Jacob JT, Levet Jr J, Edwards TA, Dassanayake N, Ketelson H: Visualization hydrophobic domains in silicone hydrogel lenses with Sudan IV. Invest Ophth Vis Sci, 2012; 53:3473-3480.
Ham BM, Jacob JT, Cole R: Single eye analysis and contralateral eye comparison of tear proteins in normal and dry eye model rabbits by MALDI_ToF mass spectrometry using wax-coated target plates. Anal Bioanal Chem, 387:889-900, 2007. PM:17211596
Selvam S, Thomas PB, Trousdale MD, Stevenson D, Schechter JE, Mircheff AK, Jacob JT, Smith RE, Yiu SC: Tissue-engineered tear secretory system: Functional lacrimal gland acinar cells cultured on matrix protein-coated substrata. J Biomed Mater Res B Appl Biomater,80: 192-200, 2007. PM:16850479
Ham BM, Cole R, Jacob JT: Identification and comparison of the polar phospholipids in normal and dry eye rabbit tears by maldi-TOF mass spectrometry. Invest Ophthalmol Vis Sci, 47 (8):3330-3338, 2006. PM:16877399
Ham BM, Jacob JT, Cole RB: MALDI-TOF MS of phosphorylated lipids in biological fluids using immobilized metal affinity chromatography and a solid ionic crystal matrix. Anal Chem, 77:4439-4447, 2005. PM:16013857
Jacob JT, Rochefort J, Bi J, Gebhardt BM: Corneal epithelial cell growth over tethered-protein/peptide surface-modified hydrogels. J Biomed Mater Res, Part B., 72B:198-205, 2005. PM:15486971
Wallace C, Jacob JT, Stoltz A, Bi J, Bundy K: Corneal epithelial adhesion strength to tethered-protein/peptide modified hydrogel surfaces. J Biomed Mater Sci, Part A., 72A(1):19-24, 2005. PM:15534866
Ham BM, Jacob JT, Keese MM, Cole RB: Identification, quantification and comparison of major non-polar lipids in normal and dry eye tear lipidomes by electrospray tandem mass spectrometry. J Mass Spectrometry, 39(11):1321-1336, 2004. PM:15532045
Bi J, Downs C, Jacob JT: Tethered protein/peptide-surface-modified hydrogels. J Biomater Sci Polymer Edn 15(7):905-916, 2004. PM:15318800