Michael S. Lan, PhD

Professor, Department of Genetics
Louisiana State University Health Sciences Center, New Orleans
Children’s Hospital Professorship of Pediatric Research


1976 - B.S. in Chemistry, SooChow University, Taiwan, R.O.C.
​1980 - M.S. in Molecular Biology, National Tsing Hua University, Taiwan, R.O.C.
1986 - Ph.D. in Microbiology and Immunology, Duke University, Durham, NC USA

Research Interests

  • Study of transcription factor in neuroendocrine (NE) differentiation and transformation.
  • Signaling pathways involved in NE development.
  • Molecular targeting transcription factor and signaling pathway against NE tumors.
  • Evaluation of NE biomarker diagnosis and drug therapeutic discovery.
  • Study of insulin autoimmunity, tolerance, and type 1 diabetes (T1D).

Selected Publications


  1. Chen, C., Breslin, M.B., and Lan, M.S.: Sonic hedgehog signaling pathway regulates INSM1 transcription factor in neuroendocrine lung cancer. Cell. Signal. 46: 83-91, 2018.
  2. Wang, L., Sun, Z.S., Xiang, B., Wei, C., Wang, Y., Sun, K., Chen, G., Lan, M.S., Carmona, G.N., Notkins, A.L., and Cai, T.: Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. J. Transl. Med., 16: 297-305, 2018.
  3. Chen, C., Breslin, M.B., Guidry, J.J., and Lan, M.S.: 5’-iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth. J. Biol. Chem.,294: 5456-5465, 2019.
  4. Chen, C., Notkins, A.L., and Lan M.S.: Insulinoma-associated-1 (IA-1/INSM1): From neuroendocrine tumor marker to cancer therapeutics. In press. Mol. Cancer Res., 17(8): 1597-1604, 2019.
  5. Chen C, Lan M.S.: A promoter-driven assay for INSM1-associated signaling pathway in NB. Cell Signal., 76: 109785, 2020
  6. Chen, C. and Lan, M.S.: Interplay: the essential role between INSM1 and N-Myc in aggressive NB. Biology, 11: 1376, 2022.
  7. Chen, C., Wu, J., Hicks, C., and Lan, M.S.: Repurposing a plant alkaloid homoharringtonine targets INSM1 in N-Myc-activated NB, Cell. Signal., 109: 110753, 2023.
  8. Lan, M.S. and Chen, C.: Small molecules targeting INSM1 for the treatment of high-risk neuroblastoma. Biology, 12: 1134, 2023.