Bio
Dr. Vedeckis obtained his Bachelor of Science in Biological Sciences from Loyola University
in Chicago in 1970. His Doctorate in Biological Sciences was awarded in 1974 from
Northwestern University in Evanston, IL. From 1974 to 1979, Dr. Vedeckis was an NIH
postdoctoral fellow in the Department of Cell Biology at Baylor College of Medicine
in Houston. During this time he began his research on the molecular mechanism of steroid
hormone receptor action. Since 1979, he has been a faculty member in the Department
of Biochemistry and Molecular Biology at LSUHSC in New Orleans.
Education
BS, Biological Sciences - 1970
Loyola University, Chicago, IL
PhD, Biological Sciences - 1974
Northwestern University, Evanston, IL
Post-doctoral fellowship - 1974-1979
Department of Cell Biology
Baylor College of Medicine, Houston, TX
Selected Publications
Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to
glucocorticoids in dexamethasone-resistant human malignant lymphoid cells. Miller AL, Geng C, Golovko G, Sharma M, Schwartz JR, Yan J, Sowers L, Widger WR, Fofanov
Y, Vedeckis WV, Thompson EB. Cancer Cell Int. 2014 Apr 23;14:35. doi: 10.1186/1475-2867-14-35. eCollection 2014. PMID: 24795534
Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis. Sarvaiya PJ, Schwartz JR, Hernandez CP, Rodriguez PC, Vedeckis WV. Am J Hematol. 2012 Oct;87(10):969-76. doi: 10.1002/ajh.23283. Epub 2012 Jul 5.
PMID: 22764095
A facile, branched DNA assay to quantitatively measure glucocorticoid receptor auto-regulation
in T-cell acute lymphoblastic leukemia. Schwartz JR, Sarvaiya PJ, Leiva LE, Velez MC, Singleton TC, Yu LC, Vedeckis WV. Chin J Cancer. 2012 Aug;31(8):381-91. doi: 10.5732/cjc.012.10044. Epub 2012 Jun
26. PMID: 22739263
c-Myb interacts with the glucocorticoid receptor and regulates its level in pre-B-acute
lymphoblastic leukemia cells. Sarvaiya PJ, Schwartz JR, Geng CD, Vedeckis WV. Mol Cell Endocrinol. 2012 Sep 25;361(1-2):124-32. doi: 10.1016/j.mce.2012.03.024. Epub 2012 Apr 10.
PMID: 22516378
A new, lineage specific, autoup-regulation mechanism for human glucocorticoid receptor
gene expression in 697 pre-B-acute lymphoblastic leukemia cells. Geng CD, Vedeckis WV. Mol Endocrinol. 2011 Jan;25(1):44-57. doi: 10.1210/me.2010-0249. Epub 2010 Nov 17. PMID: 21084380
Research Interests
Steroid hormone action
Structure, function, and genomic interactions of glucocorticoid receptor proteins
Steroid hormone regulation of proto-oncogene expression and cellular proliferation
Leukemia
