Education

2024 – Postdoctoral Fellowship, Human Genetics

University of California, Los Angeles

2019 – Ph.D., Molecular Physiology & Biophysics

Vanderbilt University

2008 – B.S., Molecular Biology

University of Tennessee, Chattanooga

Publications

Please, find a complete list of Dr. Wiese's publications here.

Select Publications:

1. Zhang P, Munier JJ, Wiese CB, Vergnes L, Link J, Ronquillo E, Munoz A, Kuang Y, Liu M, Sanchez-Kaiser G, Oni-Orisan A, Iribarren C, Nomura DK, Krauss RM, Medina MW, and Reue K. X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction. Nature Communications. 2024. Jul 2;15(1):5571.

2. Wiese CB, Avetisyan R, and Reue K. The impact of chromosomal sex on cardiometabolic health and disease. Trends in Endocrinology and Metabolism. 2023. Oct; 34(10):652-665.

3. Wiese CB, Agle ZW, Zhang P, and Reue K. Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment. Biology of Sex Differences. 2022. Nov 4;13(1):63.

4. Link J*, Wiese CB*, Chen X, Avetisyan R, Ronquillo E, Ma F, Guo X, Yao J, Allison M, Chen Y, Rotter J, Moustafa J, Small K, Iwase S, Pellegrini M, Vergnes L, Arnold A, and Reue K. X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. The Journal of Clinical Investigation. 2020. 130(11):5688-5702.

5. Wiese CB, Zhong J, Xu Z, Zhang Y, Ramirez-Solano M, Zhu W, Linton MF, Sheng Q, Kon V, and Vickers KC. Dual inhibition of endothelial miRNA-92a-3p and miRNA-489-3p reduces renal injury-associated atherosclerosis. Atherosclerosis. 2019. 282:121-131.

Research

The Wiese laboratory investigates the impact of sex components—gonads and sex chromosomes—on cardiometabolic physiology. The impact of gonadal hormones on physiology has been well characterized; however, the impact of genetic sex has been under studied. The sex chromosome complement (XX and XY) causes unequal gene dosage by 1) the presence and absence of Y chromosome genes and 2) a subset of X chromosome genes escape X chromosome inactivation leading to higher expression in XX cells than XY cells. These two mechanisms of unequal sex chromosome gene dosage modulate cellular function and impact whole body physiology.

Current research projects:

· Utilizing a multi-omics approach to assess the impact of gonadal and genetic sex on hepatic function during fatty liver disease.

· Evaluating the impact of gonadal and genetic sex on epigenetic regulation in atherosclerosis.

· Determining the role of X chromosome gene, Kdm6a, in brown adipose energy metabolism and adaptation to cold.

Lab Members