Yue photo

Xinping Yue, M.D., Ph.D.

Assistant Professor

Office: MEB 7224; Lab: MEB 7241
1901 Perdido Street
New Orleans, LA 70112
Phone: (504) 568‐2024
FAX: (504) 568‐6158
xyue@lsuhsc.edu

Degrees

1995  -  M.D.
     Beijing Medical University

2000 - Ph.D.
    Anatomy and Cell Biology, University of Iowa

Bio 2001–2003 Postdoctoral Associate, Department of Biology, Massachusetts Institute of Technology (Laboratory of Dr. Robert D. Rosenberg)
2003–2005 Postdoctoral Fellow, Department of Pathology and Laboratory Medicine, University of Wisconsin‐Madison (Laboratory of Dr. Alan C. Rapraeger)
2006–2008 Postdoctoral Fellow, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University Health Sciences Center (Laboratory of Dr. Joseph A. Lasky)
Research Interests

Research in my laboratory focuses on understanding the pathophysiology and molecular mechanisms of lung diseases. We have long-standing interests in the function of heparan sulfate, in particular heparan sulfate 6-O-endosulfatases (the Sulfs), in the development of lung diseases including idiopathic pulmonary fibrosis and acute lung injury. Recently we started a new collaborative project with Dr. Jason Gardner (Physiology) and Dr. Eric Lazartigues (Pharmacology) to examine the effects of chronic nicotine inhalation on the development of cardiopulmonary diseases with a focus on the renin-angiotensin system. Below is a list of current active projects:

  • Understand the function of the Sulfs in lung injury, inflammation, repair, and regeneration.

  • Explore the therapeutic values of recombinant Sulfs as well as heparin analogs in the treatment of lung injury, inflammation, and fibrosis.

  • Examine the impact of chronic nicotine inhalation on the development of lung diseases and its associated molecular mechanisms.

Teaching Activities

Area of Expertise:

            Pulmonary Physiology

Course Co-Directorship:

            HLSC 2410 - Nursing Human Physiology

      DHY 3202 - General and Oral Physiology

Lecturer:

INTER 132/PHTH 7122 - Biological Systems

HLSC 3410/HLSC 6410 – Nursing Pathophysiology

HLSC 2410 – Nursing Human Physiology

DHY 3202 - General and Oral Physiology

Selected Publications

Yue X. (2017) Epithelial deletion of Sulf2 exacerbates bleomycin-induced lung injury, inflammation and mortality. Am J Respir Cell Mol Biol. 2017 Jun 28. doi: 10.1165/rcmb.2016-0367OC. [Epub ahead of print] PMID: 28657777

Chodavarapu H, Chhabra KH, Xia H, Shenoy V, Yue X, Lazartigues E. (2016) High-fat diet-induced glucose dysregulation is independent of changes in Islet ACE2 in mice. Am J Physiol Regul Integr Comp Physiol. 311(6):R1223-R1233. PMID: 27806985

Lu J, Auduong L, White ES, YueX. Upregulation of Heparan Sulfate 6-O-Sulfation in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 50(1):106-14. PMID: 23962103

Yue X, Lu J, Auduong L, Sides MD, Lasky JA. (2013) Overexpression of Sulf2 in idiopathic pulmonary fibrosis. Glycobiology 23:709-19.

Yue X, Shan B and Lasky JA. (2010) TGF-b: Titan of Lung Fibrogenesis. Current Enzyme Inhibition 6(2):67-77. (Review)

Yue X, Li X, Nguyen HT, Levy DR, Sullivan DE, and Lasky JA. (2008) TGF-β1 induces heparan sulfate 6-O-endosulfatase 1 expression in vitro and in vivo. J Biol Chem. 283(29):20397-407. PMID: 18503048.

Feng Y, Yue X, Xia H, Bindom SM, Hickman PJ, Filipeanu CM, Wu G and Lazartigues E. (2008) Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Res. 102(6):729-36. PMID: 18258853.

Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, and Sanderson RD. (2005) HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J Biol Chem. 280(48):40066-73. PMID: 16192265.

 

Additional Info

Curriculum Vitae  
 
 

PubMed Link