Yue photo

Xinping Yue, M.D., Ph.D.

Assistant Professor

Office: MEB 7224; Lab: MEB 7241
1901 Perdido Street
New Orleans, LA 70112
Phone: (504) 568‐2024
FAX: (504) 568‐6158
xyue@lsuhsc.edu

Degrees

MD - 1995      Beijing Medical University

PhD - 2000     Anatomy and Cell Biology, University of Iowa

Bio

2001–2003      Postdoctoral Associate, Department of Biology, Massachusetts Institute of Technology (Advisor: Dr. Robert D. Rosenberg)

2003–2005      Postdoctoral Fellow, Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison (Advisor: Dr. Alan C. Rapraeger)

2006–2008      Postdoctoral Fellow, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University Health Sciences Center (Advisor: Dr. Joseph A. Lasky)

Research Interests

Research in my laboratory focuses on understanding the pathophysiology and molecular mechanisms of lung diseases. We have long-standing interests in the role of heparan sulfate 6-O-endosulfatases (the Sulfs) in the pathogenesis of idiopathic pulmonary fibrosis and acute lung injury. In addition, in collaboration with Drs. Jason Gardner (Physiology) and Eric Lazartigues (Pharmacology), we are interested in examining the effects of chronic nicotine inhalation on the development of cardiopulmonary diseases with a focus on the renin-angiotensin system. Current active projects include: understand the function of the Sulfs in lung injury, inflammation, repair and regeneration; explore the therapeutic values of recombinant Sulfs and heparin analogs in the treatment of lung injury, inflammation and fibrosis; examine the impact of chronic nicotine inhalation on the development of lung diseases and its associated molecular mechanisms.

Teaching Activities

Area of Expertise: Pulmonary Physiology

Course Directorship:

  DHY 3202 - General and Oral Physiology

Lecturer:

INTER 132/PHTH 7122 - Biological Systems

HLSC 3410/HLSC 6410 – Nursing Pathophysiology

HLSC 2410 – Nursing Human Physiology

DHY 3202 - General and Oral Physiology

DENT 1115 - Human Physiology

Selected Publications

Oakes JM, Fuchs RM, Gardner JD, Lazartigues E, Yue X. (2018) Nicotine and the Renin-Angiotensin System. Am J Physiol Regul Integr Comp Physiol. 2018 Aug 8. doi: 10.1152/ajpregu.00099.2018. [Epub ahead of print] PMID: 30088946.

Yue X*, Basting TM, Flanagan TW, Xu J, Lobell TD, Gilpin NW, Gardner JD, and Lazartigues E. (2018) Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin–Angiotensin System. Ann Am Thorac Soc.15(S2):S126-S127. PMID: 29676623 (*Corresponding Author)

Yue X. (2017) Epithelial deletion of Sulf2 exacerbates bleomycin-induced lung injury, inflammation and mortality. Am J Respir Cell Mol Biol. 57(5):560-569. PMID: 2865777; PMCID: PMC5705905

Chodavarapu H, Chhabra KH, Xia H, Shenoy V, Yue X, Lazartigues E. (2016) High-fat diet-induced glucose dysregulation is independent of changes in Islet ACE2 in mice. Am J Physiol Regul Integr Comp Physiol. 311(6):R1223-R1233. PMID: 27806985

Auduong L, Hogan EA, YueX. (2015) Role of Sulf2 in Alveolar Epithelial Injury and Repair. Ann Am Thorac Soc. 12(S1):S73-S74. PMID: 25830846

Lu J, Auduong L, White ES, Yue X. (2014) Upregulation of Heparan Sulfate 6-O-Sulfation in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 50(1):106-14. PMID: 23962103

Yue X*, Lu J, Auduong L, Sides MD, Lasky JA. (2013) Overexpression of Sulf2 in idiopathic pulmonary fibrosis. Glycobiology 23:709-19. (*Corresponding Author)

Yue X, Shan B and Lasky JA. (2010) TGF-b: Titan of Lung Fibrogenesis. Current Enzyme Inhibition 6(2):67-77.

Yue X, Li X, Nguyen HT, Levy DR, Sullivan DE, and Lasky JA. (2008) TGF-β1 induces heparan sulfate 6-O-endosulfatase 1 expression in vitro and in vivo. J Biol Chem. 283(29):20397-407. PMID: 18503048.

Feng Y, Yue X, Xia H, Bindom SM, Hickman PJ, Filipeanu CM, Wu G and Lazartigues E. (2008) Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Res. 102(6):729-36. PMID: 18258853.

 

 

Additional Info

Curriculum Vitae