Ashok Pullikuth, PhD

Research Instructor of Pharmacology

Academic Office

Department of Pharmacology

LSUHSC School of Medicine-New Orleans

1901 Perdido Street MEB#5208

New Orleans, Louisiana70112

Phone: (504) 568-2795

Fax:     (504) 568-2361

Email: apulli@lsuhsc.edu

 

Laboratory:

Department of Pharmacology

LSUHSC School of Medicine-New Orleans

Medical Education Bldg #5238

1901 Perdido Street

New Orleans, Louisiana70112

Phone: (504) 568-2223

Degrees

PhD (1998)  University of California, Riverside, California, USA

Bio

Assistant Professor Research-Neuroscientist/Cell Biologist (2001-2003): Department of Cell Biology and Neuroscience, University of California, Riverside, California92521, USA

 

Instructor-Research (2008 - ): Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA

 

 

Postdoctorates:

 

1998: Departments of Cell Biology and Neuroscience and Entomology, University of California, Riverside92521, California, USA

 

1998-2001: Department of Biochemistry and Molecular Biology, Saint Louis University, School of Medicine, Saint Louis, Missouri, USA

 

2003-2007: Department of Pharmacology and Experimental Therapeutics, LouisianaStateUniversityHealthSciencesCenter, New Orleans, Louisiana, USA

 

Academic Memberships:

 

Associate Member: Sigma Xi

Member: Gamma Sigma Delta, Honor Society

Member: New YorkAcademy of Sciences

Member: American Society of Cell Biology

Member: American Association for the Advancement of Sciences (AAAS)

 

Consultant:

 

Human Protein Reference Database (HPRD), Institute of Bioinformatics and JohnsHopkinsUniversity: Trafficking GTPases and ATPases (www.hprd.org and www.ncbi.nlm.nih.gov/pubmed/14681466)

 

Research Interests

1)  Reciprocal Regulation of Trafficking and Signaling

2)  Cell Biology of Signaling Scaffolds

3)  Nodes of Signal Integration in RTKs and GTPases Signaling

 

Teaching Activities

Advanced Nursing Pharmacology

Dental Pharmacology

Nursing Pharmacology

Selected Publications

Pullikuth, A. K., and Weidman, P. J. (2002). In vitro transport on cis and trans sides of the Golgi involves two distinct types of coatomer and ADP-ribosylation factor-independent transport intermediates. Journal of Biological Chemistry 277, 50355-50364.  

Pullikuth, A. K., and Gill, S. S. (2002). In vivo membrane trafficking role for an insect N-ethylmaleimide-sensitive factor which is developmentally regulated in endocrine cells. Journal of Experimental Biology 205, 911-926.  

Zhuang, M., Oltean, D. I., Gomez, I., Pullikuth, A. K., Soberon, M., Bravo, A., and Gill, S. S. (2002). Heliothis virescens and Manduca sexta lipid rafts are involved in Cry1A toxin binding to the midgut epithelium and subsequent pore formation. Journal of Biological Chemistry 277, 13863-13872.  

Pullikuth, A. K., Filippov, V., and Gill, S. S. (2003). Phylogeny and cloning of ion transporters in mosquitoes. Journal of Experimental Biology 206, 3857-3868.

Pullikuth, A., McKinnon, E., Schaeffer, H. J., and Catling, A. D. (2005). The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Molecular and Cellular Biology 25, 5119-5133.  

Pullikuth, A. K., K. Aimanova, W. Kang’ethe, H. R. Sanders, and S.S. Gill. (2006). Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegypti. Journal of Experimental Biology209: 3529-3544.  

Kang’ethe, W. K., K. Aimanova, S. S. Gill and A. K. Pullikuth . (2007). NHE8 mediates amiloride sensitive Na+/H+ exchange across Malpighian tubules and catalyzes Na+ And K+ transport in reconstituted proteoliposomes. American Journal of Physiology- Renal Physiology 292: 1501-1512   

Pullikuth, A. K., and A. D. Catling (2007). Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A prespective. Cellular Signalling 19: 1621-1632

Park, E. R., A. K. Pullikuth, E. M. Bailey, D. E. Mercante, and A. D Catling. 2009.Differential requirement for MEK Partner 1 in DU145 prostate cancer cell migration. Cell Communication and Signaling, 7:26 (doi:10.1186/1478-811X-7-26)

Hu S, Delorme N, Liu Z, Liu T, Velasco-Gonzalez C, Garai J, Pullikuth A, and Koochekpour S. 2010. Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion. Molecular Cancer. Feb 4;9(1):30.

Pullikuth, A. K., and A.D. Catling. 2010. Extracellular signal-regulated kinase promotes Rho-dependent focal adhesion formation by suppressing p190A RhoGAP. Molecular and Cellular Biology, 30(13): 3233-3248.