Research

• Research in my laboratory focuses on understanding the pathophysiology and molecular mechanisms of lung diseases. We have long-standing interests in the role of heparan sulfate 6-O-endosulfatases (the Sulfs) in the pathogenesis of idiopathic pulmonary fibrosis and acute lung injury. In addition, in collaboration with Drs. Jason Gardner (Physiology) and Eric Lazartigues (Pharmacology), we are interested in examining the effects of chronic nicotine inhalation on the development of cardiopulmonary diseases with a focus on the renin-angiotensin system. Current active projects include: understand the function of the Sulfs in lung injury, inflammation, repair and regeneration; explore the therapeutic values of recombinant Sulfs and heparin analogs in the treatment of lung injury, inflammation and fibrosis; examine the impact of chronic nicotine inhalation on the development of lung diseases and its associated molecular mechanisms.

Publications

Please, find a complete list of the Yue lab publications here.

Lab Members