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David Lefer, PhD
Cardiovascular Center of Excellence
Grant Review Committees Served on:
NIH
Other Committees
Primary Research / Clinical / Teaching Interests:
Cardiovascular Pathology
Cardiovascular Physiology
Hydrogen Sulfide Signaling
Nitric Oxide Signaling
Renal Denervation
Translational Research
Secondary Research / Clinical / Teaching Interests:
Antioxidant Therapy
Fibrosis
Metabolomics
Mitochondria, Heart
Neprilysin
Unique Techniques Used or Developed:
Hydrogen Sulfide Measurement by Gas Chromatography Chemiluminescence
Model - Mouse Myocardial Infarct Induced Heart Failure
Model - Mouse Myocardial Ischemia Reperfusion Injury
Model - Mouse Transaortic Constriction (TAC) Left Ventricular Hypertrophy
Model - Rat Myocardial Infarct Induced Heart Failure
Model - Rat Myocardial Ischemia Reperfusion Injury
Model - Swine Myocardial Infarct Induced Heart Failure
Model - Swine Myocardial Ischemia Reperfusion Injury
Nitrite/Nitric Oxide Metabolite Measurement by Ion Chromatography
Unique Equipment Used:
Ex Vivo Vascular Reactivity Radnoti Organ Bath Chambers (16)
Gas Chromatography Chemiluminescence for Plasma and Tissue Hydrogen Sulfide
Ion Chromatography (ENO20 Analyzer, Eicom) for Plasma and Tissue Nitrite
Li-Cor Odyssey CLx Imaging System
Microsurgical Procedural Stations (10) for Mice
Millar Pressure Catheter/Hemodynamic Systems for Mice
Millar Pressure Catheter/Hemodynamic Systems for Rats
Surgical Procedural Stations (5) for Rats
Visual Sonics Vivo 2100 for Mice
Visual Sonics Vivo 2100 for Rats
Visual Sonics Vivo 2100 Workstations (3)
Keywords Associated with Work:
Cardiovascular Agents
Cardiovascular Physiological Processes
Cardiovascular System
Diabetes Mellitus, Experimental
Heart Failure
Hydrogen Sulfide
Metabolic Syndrome X
Models, Cardiovascular
Myocardial Ischemia
Myocardial Reperfusion Injury
Nitric Oxide
Nitric Oxide Donors
Nitric Oxide Synthase
Nitrite Reductases
Prostaglandin Antagonists
Renal Denervation
Simvastatin
Sodium Nitrite
Statin Therapy
Transaortic Constriction (TAC) Mouse Model
Last Updated: 06/22/2017
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