|Ricardo U. Sorensen
|Studies of congenital immunodeficiencies
Strep pneumoniae infections and immunity
Immune response to BCG and pneumococcal polysacchanides
|Susan Berry||Evaluate the effective of the "Reach Out and Read" Program.
Jayashree K. Rao
|No research availability at this time (per Dr. Rao)|
Raynorda F. Brown
|Biochemistry of essential and toxic minerals
Transcriptional and transnational regulation of metal-binding proteins
Zinc absorption, bioavailability, and metabolism
Pediatric gastroenteritis outcome among urban and rural disadvantaged populations
Bacterial flora of small intestine in health and disease
Breath hydrogen analysis in intractable diarrhea of infancy
Effect of an early nutritional and behavioral intervention on children with non-organic failure-to-thrive (FTT)
Oral rehydration of infants with acute diarrhea
Duodenal bacterial overgrowth as a cause of persistent diarrhea
Use of a protein-sparing modified fast (PSMF) in the outpatient treatment of pediatric obesity
Obesity in childhood and adolescence
International collaborative projects in participation with Thailand, India, Peru
Postprandial lipoprotein metabolism in humans - with Dr. M. Lefevre and Dr. P. Roheim
|Elizabeth Mannick||The focus of our laboratory's research is the pathogenesis
of inflammatory bowel disease. We currently have several projects ongoing. We are
performing microarray analysis on patient samples to try to determine the differential
expression of genes in ulcerative colitis and Crohn's disease.
We are using mouse models of colitis to determine if knocking out interferon regulatory factor-1, a gene involved in the regulation of T helper 1 responses, is protective. We are also involved in collaborative research with Dr. Pelayo Correa regarding differences in the immune response of children under and over the age of 2 to Helicobacter pylori infection. We would welcome the participation of interested students.
|Delineation of new syndromes
Dermatoglyphics in Down Syndrome
Nosology of Genetic Disorders
Diagnosis and Management of Metabolic Disorders
Therapeutic Trial in Osteogenesis Imperfecta: an international collaborative project
Incidence of congenital malformations
Search of contiguous gene syndromes
Evaluation of mitochondrial function in Prader Willi syndrome
Remote sensing in syndrome delineation
An evaluation of the effect of hGH in Prader Willi syndrome.
|R. P. Warrier, M.D.
David Ode, M.D.
Lolie C. Yu
Renee V. Gardner
|Sleep apnea, pulmonary function studies in children with sickle cell
Soluble IL2 receptors as a prognostic indicator in A.L.L. - (clinical & lab)
Soluble CD8 antigen and Protein Kinase C activity in childhood leukemia
Protocol chemotherapy studies in all childhood cancers
Correlation of nutritional status with immunological function and progression to AIDS and HIV
Immune activation as measured by Neopterin and soluble IL2 receptor levels in HIV positive hemophiliac
Nutritional status and its relation to growth and infections in sickle cell anemia
Nutritional status of children with cancer at diagnosis, during therapy, and in remission
Effect of nutritional status on immune reconstitution of children undergoing bone marrow transplantation
Autologous BMT - role in childhood cancers
Central line infection in immunocompromised children
Use of Fluconazole as antifungal therapy for oral moniliasis in children with cancer
Development of techniques for T-cell depletion in bone marrow transplant
Audiometric evaluators in children receiving cispeatims
A. Stromal damage after chemotherapy: Our focus has been the examination of late-effects resulting from the chemotherapy and radiation therapy given to individuals with cancer. While the survival of patients diagnosed with cancer is escalating (it is anticipated that by 2020, 1 out of every 250 young people in the United States will be a survivor of cancer), we have become increasingly aware, with the passage of time, of late complications of treatment that imperil survival. Examples of this risk are the marrow hypoplastic and aplastic states that may result for the use of chemotherapeutic agents. While we suspect that such marrow proliferative damage results from an attrition of stem cell numbers, there is also evidence for qualitative damage to hematopoietic stem cells that is not readily explained. Less clear is the effects of chemotherapy on stroma. We are examining mechanisms of damage, including changes to the marrow microenvironment, and ways of preventing such damage.
B. The use of rasayana, ICHOR,-and herbal remedy-, in the protection of heart from Doxorubicin: Another problem that has become apparent especially recently is that of cardiomyopathy induced by Doxorubicin. This is a complication that may affect up to 66% of patients receiving this chemotherapeutic drug, and it may be seen up to 20 years later. We are examining the mechanisms of damage, as well as the use of nutritional supplements such as carnitine, and herbal remedies to prevent or allay the onset of cardiomyopathy. One such herbal medication, ICHOR, is a part of the Ayurvedic system of medicine in India and has been reputed to be a immunorestorative and myeloprotectant. Our research entails the analysis of this herb as a cardioprotectant, using a model of chronic or delayed onset cardiotoxicity. We are also looking at the effects of this drug on other organ systems as well, including on the long-term repopulating capacity of marrow.
|Rodolfo E. Begue, M.D.||Helicobacter pylori
Muscosal immunity and vaccine development
|Epidemiology of neonatal necrotizing enterocolitis inflammation Mast cell
activation and intestinal injury
Intestinal blood flow in piglets
Dexamethasone pulse therapy for bronchopulmonary dysplasia
Caritine metabolism in newborns
Nitric oxide metabolism
Intrauterine growth retardation
Pharmacologic therapy of primate colitis
|Jay K. Kolls, M.D.
Bonnie Desselle, M.D.
|Gene Therapy for the following diseases:
Duchenne Muscular Dystrophy
Development of novel recombinant Adenoviruses for Vaccine/Gene delivery, Effect of Ethanol on Pulmonary Host Defenses against bacteria